4 research outputs found
Universität Frankfurt vermarktet ihr geistiges Eigentum : Grundlagenforscher und Erfinder in einem ...
Schistosoma mansoni: Control of female fertility by the male
We have established an in vitro culture system for adult schistosomes
that allows monitoring gene expression for up to more than ten days.
Comparing female worms that are paired with those that have been
separated, we find distinct differences, clearly documenting an
influence of the male in female gene expression. In perfect coincidence
with classical observations that were based on histological techniques,
we find that the male particularly regulates gene expression in those
tissues that are characterized by cell proliferation, e.g. the
vitellaria. From these results, we hypothesize that the key target for
the inductive signal that is transferred from the male to the female
during pairing is the activation of a growth factor that stimulates
mitotic proliferation