59 research outputs found

    Rights, Bodies and the Law: Towards a Feminist Ethics of Justice

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    Also CSST Working Paper #117.http://deepblue.lib.umich.edu/bitstream/2027.42/51308/1/544.pd

    Hindu Rashtra and Bollywood: A New Front in the Battle for Cultural Hegemony

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    This paper examines the weaponization by Hindu right-wing politics of the suicide of a young Hindi film actor in September 2020. It argues that his death was invoked in particular ways to sharpen the attack on the Bombay film industry as part of the larger concerted move by the RSS to control and purge spaces seen as either controlled by тАЬleft liberals,тАЭ or as syncretic and unamenable to Hindu-Muslim polarization. In the course of this attack, some differences within the Hindutva camp have become evident, a phenomenon this paper examines closely

    Assessing 88Sr Concentration and 86/87Sr Ratio Variations in Rainbow Smelt Otoliths using Laser Ablation Mass Spectrometry

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    This study aims to understand Rainbow Smelt life history traits in Beaufort Sea's nearshore waters. Our objective is to analyze Rainbow Smelt otolith 88Sr concentrations and 86/87Sr ratios in marine and freshwater sites. We hypothesize that there are higher 88Sr concentrations and 86/87Sr ratios in marine otolith edges

    Functional SNP allele discovery (fSNPd): an approach to find highly penetrant, environmental-triggered genotypes underlying complex human phenotypes.

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    BACKGROUND: Significant human diseases/phenotypes exist which require both an environmental trigger event and a genetic predisposition before the disease/phenotype emerges, e.g. Carbamazepine with the rare SNP allele of rs3909184 causing Stevens Johnson syndrome, and aminoglycosides with rs267606617 causing sensory neural deafness. The underlying genotypes are fully penetrant only when the correct environmental trigger(s) occur, otherwise they are silent and harmless. Such diseases/phenotypes will not appear to have a Mendelian inheritance pattern, unless the environmental trigger is very common (>50% per lifetime). The known causative genotypes are likely to be protein-altering SNPs with dominant/semi-dominant effect. We questioned whether other diseases and phenotypes could have a similar aetiology. METHODS: We wrote the fSNPd program to analyse multiple exomes from a test cohort simultaneously with the purpose of identifying SNP alleles at a significantly different frequency to that of the general population. fSNPd was tested on trial cohorts, iteratively improved, and modelled for performance against an idealised association study under mutliple parameters. We also assessed the seqeuncing depath of all human exons to determine which were sufficiently well sequenced in an exome to be sued by fSNPd - by assessing forty exomes base by base. RESULTS: We describe a simple methodology for the detection of SNPs capable of causing a phenotype triggered by an environmental event. This uses cohorts of relatively small size (30-100 individuals) with the phenotype being investigated, their exomes, and thence seeks SNP allele frequencies significantly different from expected to identify potentially clinically important, protein altering SNP alleles. The strengths and weaknesses of this approach for discovering significant genetic causes of human disease are comparable to Mendelian disease mutation detection and Association Studies. CONCLUSIONS: The fSNPd methodology is another approach, and has potentially significant advantage over Association studies in needing far fewer individuals, to detect genes involved in the pathogenesis of a diseases/phenotypes. Furthermore, the SNP alleles identified alter amino acids, potentially making it easier to devise functional assays of protein function to determine pathogenicity

    The effect of a low GI diet on truncal fat mass and glycated hemoglobin in South Indians with type 2 diabetesтАФA single centre randomized prospective study

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    Background: There has been no previous study that has investigated the effect of a low glycemic index (LGI) diet with local recipes of South Indian cuisine on the body fat composition using dual-energy X-ray absorptiometry (DXA). Truncal obesity has been associated with the risk of metabolic disorders and cardiovascular diseases. Aim: The aim of this study was to examine the effect of a low GI diet on glycemic control and body composition in people with type 2 diabetes in South India. Method: This was a prospective and randomized controlled study that was conducted over a period of 24 weeks. A total of 40 participants were recruited from the Department of Endocrinology and Diabetes Outpatient in Kerala, South India. All the patients had type 2 diabetes and were randomly assigned and given advice and instructions to follow either a low GI diet plan (n = 18) or their usual diet, which served as control (n = 18). The advice was reinforced throughout the study period. Dietary compliance was evaluated based on a 24 h dietary recall at weeks 3, 11, 12, 18, 23, and 24. The age of the subjects ranged from 35 to 65 years. Anthropometric, body composition, and cardio-metabolic parameters were measured according to standard procedures. T-tests were conducted to compare differences between intervention and control groups and the Pearson correlation coefficient was used to evaluate associations between the variables. Results: There were significant reductions (p < 0.05) in the low GI diet compared to the control group with respect to weight, body mass index (BMI), and triceps skinfold thickness. Similarly, significant reductions were observed in the low GI diet group with respect to region, total fat, android, and gynoid fat mass and the differences between the groups were significant at p < 0.05. There was also a positive correlation between BMI and android fat mass (r = 0.745), total fat mass (r = 0.661), total truncal mass (r = 0.821), and truncal fat (r = 0.707). There was a significant reduction in glycated hemoglobin in the low GI diet group compared to the control group at p < 0.05. Conclusion: This study has demonstrated that there was a significant reduction (p < 0.05) of truncal obesity and glycated hemoglobin in patients with type 2 diabetes on a local diet of South Indian cuisine with low GI compared with the control

    South Indian cuisine with low glycemic index ingredients reduces cardiovascular risk factors in subjects with type 2 diabetes

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    Background: Inflammation is considered as a predictor of cardiovascular diseases in type 2 diabetes mellitus. No previous studies have investigated the effect of low glycemic index (LGI) recipes of South Indian cuisine on the risk factors of cardiovascular disease in patients with diabetes. Aim: The aim of this randomized controlled trial was to evaluate the improvement in cardiovascular risk factors and blood glucose control, in patients with type 2 diabetes, after intervention with recipes of Kerala cuisine, from locally available whole grain cereals, low in glycemic index. Method: This was a prospective and randomized controlled study that was conducted over a period of 24 weeks. A total of 80 participants were recruited from the Department of Endocrinology and Diabetes Outpatient in Kerala, South India. All 80 patients had type 2 diabetes, and were aged between 35 and 65 years. Participants were randomly assigned and advised to follow either a LGI diet plan (n = 40) or their usual diet, which served as a control group (n = 40). The advice was reinforced throughout the study period. Anthropometric, biochemical parameters which included glycemic and cardio-metabolic parameters were measured according to standard procedures. T-tests were conducted to compare the differences between intervention and control groups, and the Pearson correlation coefficient was used to evaluate associations between the variables. Results: There were significant differences (p < 0.05) between the intervention and control groups with respect to weight, HbA1c, insulin, triglycerides, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP) and apolipoprotein B (ApoB). There was also a positive correlation between weight and blood glucose variables. ApoB was positively correlated with lipid profile and insulin levels. Conclusions: The long-term implementation of LGI diet of Kerala cuisine has been found to promote weight loss, enhance insulin sensitivity and reduce the cardiovascular risk

    Crossing boundaries:bras, lingerie and rape myths in postcolonial urban middle-class India

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    With the processes of modernization, urbanization and the entry of women in the formal labour market in Indian metropolitan spaces, this paper examines how the modern middle-class womanтАЩs sartorial choices become enmeshed in popular rape myths (false beliefs) that serve to blame her for the wearing of western clothing. The paper articulates the ways in which middle-class womenтАЩs social realities are shaped by historical, colonial and nationalist ideologies of modernization, constructed and mediated through moral codes of dressing. By drawing upon original and contemporary empirical narratives from the urban spaces of Delhi and Mumbai, we emphasise how everyday sartorial choices, in relation to particularly the bra and lingerie, can reveal the nuanced ways in which Urban Indian Professional Women (UIPW) seek to understand, negotiate, and resist patriarchal power. Our findings shed light on conflicting and contradictory spatial experiences, where some women internalize and negotiate moral codes of dressing, out of fear, and others who transgress are subject to sanctions. Given the paucity of scholarly literature in this area, the paper makes an important theoretical and empirical contribution with its focus on postcoloniality and everyday discursive material spaces of gendered and sexualized dress practices. It argues for the consciousness raising of everyday urban geographies of dress that reveal complicated structures of power that are often deemed hidden

    рдорд╣рд┐рд╖рд╛рд╕реБрд░: рдорд┐рдердХ рд╡ рдкрд░рдВрдкрд░рд╛рдПрдВ

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    рдЗрдХреНрдХрд╕рд╡реАрдВ рд╕рджреА рдХреЗ рджреВрд╕рд░реЗ рджрд╢рдХ рдореЗрдВ рднрд╛рд░рдд рдореЗрдВ рдорд╣рд┐рд╖рд╛рд╕реБрд░ рдЖрдВрджреЛрд▓рди рджреНрд╡рд┐рдЬ рд╕рдВрд╕реНрдХреГрддрд┐ рдХреЗ рд▓рд┐рдП рдЪреБрдиреМрддреА рдмрдирдХрд░ рдЙрднрд░рд╛ред рдЗрд╕рдХреЗ рдорд╛рдзреНрдпрдо рд╕реЗ рдЖрджрд┐рд╡рд╛рд╕рд┐рдпреЛрдВ, рдкрд┐рдЫрдбрд╝реЛрдВ рдФрд░ рджрд▓рд┐рддреЛрдВ рдХреЗ рдПрдХ рдмрдбрд╝реЗ рд╣рд┐рд╕реНрд╕реЗ рдиреЗ рдЕрдкрдиреА рд╕рд╛рдВрд╕реНрдХреГрддрд┐рдХ рджрд╛рд╡реЗрджрд╛рд░реА рдкреЗрд╢ рдХреАред рд▓реЗрдХрд┐рди рдпрд╣ рдЖрдВрджреЛрд▓рди рдХреНрдпрд╛ рд╣реИ, рдЗрд╕рдХреА рдЬрдбрд╝реЗрдВ рд╕рдорд╛рдЬ рдореЗрдВ рдХрд╣рд╛рдВ рддрдХ рдлреИрд▓реА рд╣реИрдВ, рдмрд╣реБрдЬрдиреЛрдВ рдХреА рд╕рд╛рдВрд╕реНрдХреГрддрд┐рдХ рдкрд░рдВрдкрд░рд╛ рдореЗрдВ рдЗрд╕рдХрд╛ рдХреНрдпрд╛ рд╕реНрдерд╛рди рд╣реИ, рдореМрдЬреВрджрд╛ рд▓реЛрдХ-рдЬреАрд╡рди рдореЗрдВ рдорд╣рд┐рд╖рд╛рд╕реБрд░ рдХреА рдЙрдкрд╕реНрдерд┐рддрд┐ рдХрд┐рди-рдХрд┐рди рд░реВрдкреЛрдВ рдореЗрдВ рд╣реИ, рдЗрд╕рдХреЗ рдкреБрд░рд╛рддрд╛рддреНрд╡рд┐рдХ рд╕рд╛рдХреНрд╖реНрдп рдХреНрдпрд╛ рд╣реИрдВ? рдЧреАрддреЛрдВ-рдХрд╡рд┐рддрд╛рдУрдВ рд╡ рдирд╛рдЯрдХреЛрдВ рдореЗрдВ рдорд╣рд┐рд╖рд╛рд╕реБрд░ рдХрд┐рд╕ рд░реВрдк рдореЗрдВ рдпрд╛рдж рдХрд┐рдП рдЬрд╛ рд░рд╣реЗ рд╣реИрдВ рдФрд░ рдЕрдХрд╛рджрдорд┐рдХ-рдмреМрджреНрдзрд┐рдХ рд╡рд░реНрдЧ рдХреЛ рдЗрд╕ рдЖрдВрджреЛрд▓рди рдиреЗ рдХрд┐рд╕ рд░реВрдк рдореЗрдВ рдкреНрд░рднрд╛рд╡рд┐рдд рдХрд┐рдпрд╛ рд╣реИ, рдЙрдирдХреА рдкреНрд░рддрд┐рдХреНрд░рд┐рдпрд╛рдПрдВ рдХреНрдпрд╛ рд╣реИрдВ? рдЖрджрд┐ рдкреНрд░рд╢реНрдиреЛрдВ рдкрд░ рд╡рд┐рдорд░реНрд╢ рд╣рдореЗрдВ рдПрдХ рдРрд╕реА рдмреМрджреНрдзрд┐рдХ рдпрд╛рддреНрд░рд╛ рдХреА рдУрд░ рд▓реЗ рдЬрд╛рдиреЗ рдореЗрдВ рд╕рдХреНрд╖рдо рд╣реИрдВ, рдЬрд┐рд╕рд╕реЗ рд╣рдордореЗрдВ рдЕрдзрд┐рдХрд╛рдВрд╢ рдЕрднреА рддрдХ рдЕрдкрд░рд┐рдЪрд┐рдд рд░рд╣реЗ рд╣реИрдВред рдХреНрдпрд╛ рдорд╣рд┐рд╖рд╛рд╕реБрд░ рджрдХреНрд╖рд┐рдг рдПрд╢рд┐рдпрд╛ рдХреЗ рдЕрдирд╛рд░реНрдпреЛрдВ рдХреЗ рдкреВрд░реНрд╡рдЬ рдереЗ, рдЬреЛ рдмрд╛рдж рдореЗрдВ рдПрдХ рдорд┐рдердХреАрдп рдЪрд░рд┐рддреНрд░ рдмрди рдХрд░ рдмрд╣реБрдЬрди рд╕рдВрд╕реНрдХреГрддрд┐ рдХреЗ рдкреНрд░рддреАрдХ рдкреБрд░реБрд╖ рдмрди рдЧрдП? рдХреНрдпрд╛ рдпрд╣ рдмрд╣реБрдд рдмрд╛рдж рдХреА рдкрд░рд┐рдШрдЯрдирд╛ рд╣реИ, рдЬрдм рдорд╛рдХрдгреНрдбреЗрдп рдкреБрд░рд╛рдг, рджреБрд░реНрдЧрд╛рд╕рдкреНрддрд╢рддреА рдЬреИрд╕реЗ рдЧреНрд░рдВрде рд░рдЪ рдХрд░, рдПрдХ рдХрдкреЛрд▓-рдХрд▓реНрдкрд┐рдд рджреЗрд╡реА рдХреЗ рд╣рд╛рдереЛрдВ рдорд╣рд┐рд╖рд╛рд╕реБрд░ рдХреА рд╣рддреНрдпрд╛ рдХреА рдХрд╣рд╛рдиреА рдЧрдврд╝реА рдЧрдИ? рдЗрд╕ рдЖрдВрджреЛрд▓рди рдХреА рд╕реИрджреНрдзрд╛рдВрддрд┐рдХреА рдХреНрдпрд╛ рд╣реИ? рдкреНрд░рдореЛрдж рд░рдВрдЬрди рджреНрд╡рд╛рд░рд╛ рд╕рдВрдкрд╛рджрд┐рдд рдХрд┐рддрд╛рдм тАЬрдорд╣рд┐рд╖рд╛рд╕реБрд░: рдорд┐рдердХ рд╡ рдкрд░рдВрдкрд░рд╛рдПрдВтАЭ рдореЗрдВ рд▓реЗрдЦрдХреЛрдВ рдиреЗ рдЙрдкрд░реЛрдХреНрдд рдкреНрд░рд╢реНрдиреЛрдВ рдкрд░ рд╡рд┐рдЪрд╛рд░ рдХрд┐рдпрд╛ рд╣реИ рддрдерд╛ рд╡рд┐рд▓реБрдкреНрддрд┐ рдХреЗ рдХрдЧрд╛рд░ рдкрд░ рдЦрдбрд╝реЗ рдЕрд╕реБрд░ рд╕рдореБрджрд╛рдп рдХрд╛ рд╡рд┐рд╕реНрддреГрдд рдиреГрд╡рдВрд╢рд╢рд╛рд╕реНрддреНрд░реАрдп рдЕрдзреНрдпрдпрди рднреА рдкреНрд░рд╕реНрддреБрдд рдХрд┐рдпрд╛ рд╣реИред рдЗрд╕ рдкреБрд╕реНрддрдХ рдореЗрдВ рд╕рдордХрд╛рд▓реАрди рднрд╛рд░рддреАрдп рд╕рд╛рд╣рд┐рддреНрдп рдореЗрдВ рдорд╣рд┐рд╖рд╛рд╕реБрд░ рдкрд░ рд▓рд┐рдЦреА рдЧрдИ рдХрд╡рд┐рддрд╛рдУрдВ рд╡ рдЧреАрддреЛрдВ рдХрд╛ рдкреНрд░рддрд┐рдирд┐рдзрд┐ рд╕рдВрдХрд▓рди рднреА рд╣реИ рддрдерд╛ рдорд╣рд┐рд╖рд╛рд╕реБрд░ рдХреА рдмрд╣реБрдЬрди рдХрдерд╛ рдкрд░ рдЖрдзрд╛рд░рд┐рдд рдПрдХ рдирд╛рдЯрдХ рднреА рдкреНрд░рдХрд╛рд╢рд┐рдд рд╣реИред рд╕рдорд╛рдЬ-рд╡рд┐рдЬреНрдЮрд╛рди рд╡ рд╕рд╛рдВрд╕реНрдХреГрддрд┐рдХ рд╡рд┐рдорд░реНрд╢ рдХреЗ рдЕрдзреНрдпреЗрддрд╛рдУрдВ, рд╕рд╛рдорд╛рдЬрд┐рдХ-рд░рд╛рдЬрдиреАрддрд┐рдХ рдХрд╛рд░реНрдпрдХрд░реНрддрд╛рдУрдВ, рд╕рд╛рд╣рд┐рддреНрдп рдкреНрд░реЗрдорд┐рдпреЛрдВ рдХреЗ рд▓рд┐рдП рдпрд╣ рдПрдХ рдЖрд╡рд╢реНрдпрдХ рдкреБрд╕реНрддрдХ рд╣реИ
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