Thyroid-like low grade Nasopharyngeal Papillary Adenocarcinoma in a 20 year old student: A case report and review of literature

Low grade nasopharyngeal papillary adenocarcinoma (LGNPA) is a rare variant of nasopharyngeal adenocarcinoma with an excellent prognosis and a histo-morphologic similarity with papillary thyroid carcinoma(PTC). It can be  differentiated from PTC using ThyroidTranscriptionFactor-1 (TTF-1) and Thyroglobulin immunostains. We report a case of thyroid-like LGNPA in a 20 year old Nigerian student.Keywords: Papillary Adenocarcinoma, Nasopharynx, Thyroglobulin, Thyroid Transcription Factor-1

Histopathological Evaluation of Myometrial Lesions of the Uterus in Nnewi Teaching Hospital: (Five‑Year Retrospective Study)

Introduction: A 5‑year retrospective study to evaluate the lesions of myometrium (both nonneoplastic and neoplastic) in the hysterectomyand myomectomy specimens received in our institution. Aim: This research will serve as a baseline study of different myometrial lesions in the histopathology department of Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi. This is the first of such a study since the institution of the department. The study will also highlight myometrial lesions in relation to the age and mode of presentations as well as histopathological features. Methodology: The pathology report forms in the histopathology department NAUTH, Nnewi, were retrieved, and relevant information was extracted. Atotal of 290 cases of myometrial lesions were obtained within the study period, of which 283 cases that fulfilled the inclusion criteria were analyzed. The processed tissues and the slides stained with regular histochemical stain (hematoxylin and eosin) technique in this 5‑year study period were reviewed by the above researchers using multi‑headed microscope (®CARL ZEISS). Results: The myometrial lesions observed include leiomyoma, leiomyomata, leiomyosarcoma, leiomyoma coexisting with adenomyosis, adenomyosis, invasive carcinosarcoma, and hemorrhagic necrosis following uterine rupture. The age range at the presentation was between 10and 80 years. The mean age for leiomyoma was 39.24 ± 8.41 standard deviation (SD), whereas the mean age for adenomyosis was 43 ± 9.86 SD.Leiomyoma was the most common myometrial lesion with a frequency of 93.9% (266 cases) and show degenerative changes in 139 cases (52.%)Followed by coexisting leiomyoma with adenomyosis which had a frequency of 3.9% (11 cases). Atotal of 184 leiomyoma cases with a frequencyof 69.2% occur in multiple nodules. Adenomyosis alone had a frequency of 3.18% (9 cases). Therefore, the total number of adenomyosis inthis research was 20 cases. Menorrhagia was the most common clinical symptoms with a frequency of 31.4% (82 cases). Leiomyosarcomahad a frequency of 1.77% (5 cases), whereas the least represented were hemorrhagic necrosis and invasive carcinosarcoma with frequenciesof 2 (0.8%) and 1 (0.4%), respectively. Conclusion: (1) Leiomyoma is the most common myometrial lesions and tends to coexist in a few cases with adenomyosis while majority of them show degenerative changes. (2) Menorrhagia is the most common presenting symptoms of myometrial lesions while the histologic examination is the only tool to differentiate these myometrial lesions with similar clinical symptoms. Keywords: Adenomyosis, invasive carcinosarcoma, leiomyoma, leiomyosarcoma, menorrhagi

Burnt out benign splenic cyst mimicking intra-abdominal malignancy - case report and review of literature.pdf

The spleen performs important immunological function. Benign cysts, neoplasms and abscesses are identifiable cystic lesions of the spleen. Splenic cysts are very rare, and consist of Type 1 (parasitic) and Type 11 (non-parasitic) cysts. Very few cases of huge splenic cysts have been reported in literature. The most common symptoms are due to pressure effects on contiguous organs, causing pain, abdominal swelling and change in bowel habit. Management of these splenic cysts iscontroversial. Indications for surgical intervention, include symptomatic or large diameter cysts (>5cm). We report a 57 year old lady with an 18 year history of recurrent left abdominal pain, progressive weight loss, easy satiety, and recurrent low grade fever. She neither had change in bowel habit, nor haematuria. Therewas no history of abdominal trauma. On physical examination, there was a left hypochondriac swelling, extending to the midline of the abdomen. She has been transfusedseverally in the past on account of recurrent anaemia. Ultrasound revealed multiple well circumscribed oval and rounded cysts of the spleen. Her haemoglobin level at presentation was 6g/dl. She had neutrophilia. She subsequently underwent total splenectomy with good surgical outcome