Global ocean heat content in the Last Interglacial

The Last Interglacial (129-116 ka) represents one of the warmest climate intervals of the last 800,000 years and the most recent time when sea level was meters higher than today. However, the timing and magnitude of peak warmth varies between reconstructions, and the relative importance of individual sources contributing to elevated sea level (mass gain versus seawater expansion) during the Last Interglacial remains uncertain. Here we present the first mean ocean temperature record for this interval from noble gas measurements in ice cores and constrain the thermal expansion contribution to sea level. Mean ocean temperature reaches its maximum value of 1.1±0.3°C warmer-than-modern at the end of the penultimate deglaciation at 129 ka, resulting in 0.7±0.3m of elevated sea level, relative to present. However, this maximum in ocean heat content is a transient feature; mean ocean temperature decreases in the first several thousand years of the interglacial and achieves a stable, comparable-to-modern value by ~127 ka. The synchroneity of the peak in mean ocean temperature with proxy records of abrupt transitions in oceanic and atmospheric circulation suggests that the mean ocean temperature maximum is related to the accumulation of heat in the ocean interior during the preceding period of reduced overturning circulation

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts

The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes. At present, very little is known about the role of gene-environment interactions in modulating craniosynostosis phenotypes, but prior evidence suggests a role for endocrine factors. Here we provide a report of the effects of thyroid hormone exposure on murine calvaria cells. Murine derived calvaria cells were exposed to critical doses of pharmaceutical thyroxine and analyzed after 3 and 7 days of treatment. Endpoint assays were designed to determine the effects of the hormone exposure on markers of osteogenesis and included, proliferation assay, quantitative ALP activity assay, targeted qPCR for mRNA expression of Runx2, Alp, Ocn, and Twist1, genechip array for 28,853 targets, and targeted osteogenic microarray with qPCR confirmations. Exposure to thyroxine stimulated the cells to express ALP in a dose dependent manner. There were no patterns of difference observed for proliferation. Targeted RNA expression data confirmed expression increases for Alp and Ocn at 7 days in culture. The genechip array suggests substantive expression differences for 46 gene targets and the targeted osteogenesis microarray indicated 23 targets with substantive differences. 11 gene targets were chosen for qPCR confirmation because of their known association with bone or craniosynostosis (Col2a1, Dmp1, Fgf1, 2, Igf1, Mmp9, Phex, Tnf, Htra1, Por, and Dcn). We confirmed substantive increases in mRNA for Phex, FGF1, 2, Tnf, Dmp1, Htra1, Por, Igf1 and Mmp9, and substantive decreases for Dcn. It appears thyroid hormone may exert its effects through increasing osteogenesis. Targets isolated suggest a possible interaction for those gene products associated with calvarial suture growth and homeostasis as well as craniosynostosis. © 2013 Cray et al

Publisher Correction: Global ocean heat content in the Last Interglacial (Nature Geoscience, (2020), 13, 1, (77-81), 10.1038/s41561-019-0498-0)

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Global ocean heat content in the Last Interglacial

The Last Interglacial (129–116 thousand years ago (ka)) represents one of the warmest climate intervals of the past 800,000 years and the most recent time when sea level was metres higher than today. However, the timing and magnitude of the peak warmth varies between reconstructions, and the relative importance of individual sources that contribute to the elevated sea level (mass gain versus seawater expansion) during the Last Interglacial remains uncertain. Here we present the first mean ocean temperature record for this interval from noble gas measurements in ice cores and constrain the thermal expansion contribution to sea level. Mean ocean temperature reached its maximum value of 1.1 ± 0.3 °C warmer-than-modern values at the end of the penultimate deglaciation at 129 ka, which resulted in 0.7 ± 0.3 m of thermosteric sea-level rise relative to present level. However, this maximum in ocean heat content was a transient feature; mean ocean temperature decreased in the first several thousand years of the interglacial and achieved a stable, comparable-to-modern value by ~127 ka. The synchroneity of the peak in mean ocean temperature with proxy records of abrupt transitions in the oceanic and atmospheric circulation suggests that the mean ocean temperature maximum is related to the accumulation of heat in the ocean interior during the preceding period of reduced overturning circulation

Radioactive and stable paleoatmospheric methane isotopes across the last deglaciation and early holocene from Taylor Glacier, Antarctica

Methane (CH4) is an important greenhouse gas with both natural and anthropogenic sources. Understanding how the natural CH4 budget has changed in response to changing climate in the past can provide insights on the sensitivity of the natural CH4 emissions to the current anthropogenic warming. Both radioactive and stable CH4 isotopes (Delta14C-CH4, delta13C-CH4, and deltaD-CH4) from ice cores in Greenland and Antarctica have been used to constrain the past CH­4 budget. Among the CH4 isotopes, 14CH4 is unique in its ability to unambiguously distinguish between "old" CH4 sources (e.g. marine clathrate, geologic sources, old permafrost) and "modern" CH4 sources (e.g. tropical and boreal wetlands). During the 2013-2014 and 2014-2015 field seasons at Taylor Glacier, Antarctica, we have successfully extracted 12 large volume ice samples across the Last Deglaciation to early Holocene (20ka-8ka BP). All samples have been successfully measured for CH4 mole fraction ([CH4]), Delta14C-14CH4, delta13C-CH4, and deltaD-CH4. The [CH4], delta13C-CH4, and deltaD-CH4 measurements in our samples are consistent with existing delta13C-CH4, and deltaD-CH4 datasets from other deep cores, confirming the integrity of CH4 in Taylor Glacier ice. Preliminary 14CH4 results across the Oldest Dryas - Bølling (OD-BO) CH4 transition suggest that the 150 ppb [CH4] increase during the transition was caused by increased wetland emissions. Early Holocene and Last Glacial Maximum (LGM) 14C results are still undergoing corrections for in-situ cosmogenic 14C based on 14CO measurements in the same samples. We will present the corrected 14CH4 results from these samples and our preliminary interpretations with regard to the strength of old CH4 sources during the LGM and early Holocene. © 2016 American Geophysical UnionTuesday, 13 December 2016 08:00 - 12:20 Moscone South - Poster Hall PP21A Abrupt Climate Change: Causes, Mechanisms, and Consequences IV Poster

The timing and effect of the earliest human arrivals in North America

The peopling of the Americas marks a major expansion of humans across the planet. However, questions regarding the timing and mechanisms of this dispersal remain, and the previously accepted model (termed ‘Clovis-first’)—suggesting that the first inhabitants of the Americas were linked with the Clovis tradition, a complex marked by distinctive fluted lithic points1—has been effectively refuted. Here we analyse chronometric data from 42 North American and Beringian archaeological sites using a Bayesian age modelling approach, and use the resulting chronological framework to elucidate spatiotemporal patterns of human dispersal. We then integrate these patterns with the available genetic and climatic evidence. The data obtained show that humans were probably present before, during and immediately after the Last Glacial Maximum (about 26.5–19 thousand years ago)2,3 but that more widespread occupation began during a period of abrupt warming, Greenland Interstadial 1 (about 14.7–12.9 thousand years before AD 2000)4. We also identify the near-synchronous commencement of Beringian, Clovis and Western Stemmed cultural traditions, and an overlap of each with the last dates for the appearance of 18 now-extinct faunal genera. Our analysis suggests that the widespread expansion of humans through North America was a key factor in the extinction of large terrestrial mammals