Dynamically tunable electromagnetically induced transparency-like metamaterial structure based on polarization sensitivity

In this paper, we propose a plasmon-induced transparency (PIT) metamaterial structure composed of Ag nanomaterials with polarization sensitivity. The metamaterial model consists of three bright modes with different resonant frequencies. The optical properties of the structure are further investigated using finite difference time domain (FDTD) method. The results show that the conversion between single-band PIT and dual-band PIT effects can be achieved by changing the polarization degree of the incident light, the number of transparent windows can be changed from one to two, and the process is accompanied by the conversion of bright and dark modes and the change of the resonance wavelength of the transmission peak. In addition, When the light is polarized in the Y-direction, the two transparency windows have different refractive index sensitivities, with FOM values of 5.94/RIU and 5.65/RIU, respectively

Optimal integration of mobile battery energy storage in distribution system with renewables

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Interpretable Deep Reinforcement Learning for Optimizing Heterogeneous Energy Storage Systems

Energy storage systems (ESS) are pivotal component in the energy market, serving as both energy suppliers and consumers. ESS operators can reap benefits from energy arbitrage by optimizing operations of storage equipment. To further enhance ESS flexibility within the energy market and improve renewable energy utilization, a heterogeneous photovoltaic-ESS (PV-ESS) is proposed, which leverages the unique characteristics of battery energy storage (BES) and hydrogen energy storage (HES). For scheduling tasks of the heterogeneous PV-ESS, cost description plays a crucial role in guiding operator's strategies to maximize benefits. We develop a comprehensive cost function that takes into account degradation, capital, and operation/maintenance costs to reflect real-world scenarios. Moreover, while numerous methods excel in optimizing ESS energy arbitrage, they often rely on black-box models with opaque decision-making processes, limiting practical applicability. To overcome this limitation and enable transparent scheduling strategies, a prototype-based policy network with inherent interpretability is introduced. This network employs human-designed prototypes to guide decision-making by comparing similarities between prototypical situations and encountered situations, which allows for naturally explained scheduling strategies. Comparative results across four distinct cases underscore the effectiveness and practicality of our proposed pre-hoc interpretable optimization method when contrasted with black-box models

A fixed-point based distributed method for energy flow calculation in multi-energy systems

Multi-energy flow calculation (M-EFC) is an essential tool for the coordinated analysis of strongly coupled electricity-gas-heating systems. However, the separate management of these subsystems poses a considerable challenge for designing a fast and reliable M-EFC method. In this paper, a fixed-point based distributed method is proposed for the M-EFC problem. The proposed method can preserve the autonomy of subsystems due to limited information exchange during the solution process. Moreo-ver, the fast and reliable convergence is achieved according to the proposed sufficient conditions based on the fixed-point theory. Besides, the proposed method is availa-ble for multi-energy systems (MES) with various coupling relationships and different structures of information ex-change. Simulations on a MES demonstrate that the pro-posed method has remarkable superiority compared to the unified Newton-Raphson method in computation time, accuracy and robustness against data loss

Antibiotics influence the risk of anti-drug antibody formation during anti-TNF therapy in Chinese inflammatory bowel disease patients

Aims: The formation of anti-drug antibodies (ADAs) during anti-tumor necrosis factor (anti-TNF) therapy is reported to lead to reducing serum drug levels, which may bring about a loss of response to treatment. Previous research has suggested an association between specific antibiotic classes and ADA formation during anti-TNF therapy. However, there are few studies specifically examining this association in Chinese inflammatory bowel disease (IBD) patients. Therefore, our study aimed to evaluate the possible effect of antibiotic use on ADA formation to anti-TNF therapy in Chinese patients with IBD.Methods: A total of 166 patients with IBD, including 149 with Crohn’s disease (CD) and 17 with ulcerative colitis (UC), were included in this retrospective analysis. These patients were initially treated with anti-TNF therapy (infliximab or adalimumab) after January 2018 and reviewed with available ADA levels before October 2023. After univariable analysis of all the variables, a multivariate Cox proportional hazards model was used to assess the association between antibiotic use and ADA development.Results: Among 166 IBD patients treated with infliximab (108/166, 65.1%) or adalimumab (58/166, 34.9%), 31 patients (18.7%) were measured as positive ADA levels. Cox proportional hazard model demonstrated an increased risk of ADA formation in IBD patients who used β-lactam-β-lactamase inhibitor combinations (BL-BLIs) (HR = 5.143, 95%CI 1.136–23.270, p = 0.033), or nitroimidazoles (HR = 4.635, 95%CI 1.641–13.089, p = 0.004) during 12 months before the ADA test. On the contrary, a reduced risk was noted in patients treated with fluoroquinolones (HR = 0.258, 95% CI 0.072–0.924, p = 0.037). Moreover, the median serum infliximab or adalimumab concentration in patients with positive ADA levels was significantly lower than that in patients with negative ADA levels (infliximab: 0.30 vs. 1.85 μg/mL, p < 0.0001; adalimumab: 0.45 vs. 7.55 μg/mL, p = 0.0121).Conclusion: ADA development is associated with various antibiotic classes. BL-BLIs and nitroimidazoles might increase the risk of ADA formation during anti-TNF therapy in Chinese IBD patients, while the treatment with fluoroquinolones could probably reduce such risk. There were certain limitations in the retrospective analysis of the study, therefore, the results are just for reference, and other studies are needed to further confirm our findings

Impacts of soil and water pollution on food safety and health risks in China

Environmental pollution and food safety are two of the most important issues of our time. Soil and water pollution, in particular, have historically impacted on food safety which represents an important threat to human health. Nowhere has that situation been more complex and challenging than in China, where a combination of pollution and an increasing food safety risk have affected a large part of the population. Water scarcity, pesticide over-application, and chemical pollutants are considered to be the most important factors impacting on food safety in China. Inadequate quantity and quality of surface water resources in China have led to the long-term use of waste-water irrigation to fulfill the water requirements for agricultural production. In some regions this has caused serious agricultural land and food pollution, especially for heavy metals. It is important, therefore, that issues threatening food safety such as combined pesticide residues and heavy metal pollution are addressed to reduce risks to human health. The increasing negative effects on food safety from water and soil pollution have put more people at risk of carcinogenic diseases, potentially contributing to ‘cancer villages’ which appear to correlate strongly with the main food producing areas. Currently in China, food safety policies are not integrated with soil and water pollution management policies. Here, a comprehensive map of both soil and water pollution threats to food safety in China is presented and integrated policies addressing soil and water pollution for achieving food safety are suggested to provide a holistic approach

Characterization and Genome Sequence of Marine Alteromonas gracilis Phage PB15 Isolated from the Yellow Sea, China

A novel marine Alteromonas gracilis siphovirus, phage PB15, was isolated from the surface water of the Yellow Sea in August 2015. It has a head diameter of 58 ± 5 nm head and a contractile tail approximately 105 ± 10 nm in length, and overall the morphology suggests that PB15 belongs to the family Siphoviridae. PB15 phage is stable at over the temperature range 0-60oC. The best MOI of these phage was 0.1 and infectivity decreased above 60oC. The results suggest that phage is stable at pH value ranging between 3.0 and 11.0. Chloroform test shows that PB15 is not a lipid-containing phage. A one-step growth curve with a strain of A. gracilis gave a latent period of 16 minutes and rise period of 24 minutes and burst size of 60 PFU/cell. Genomic analysis of PB15 reveals a genome size of 37,333bp with 45.52% G+C content, and 61 ORFs. ORF sequences accounted for 30.36% of the genome sequence. There is no obvious similarity between PB15 and other known phages by genomic comparison using the BLASTN tool in the NCBI database

Screening and identification of the dominant antigens of the African swine fever virus

African swine fever is a highly lethal contagious disease of pigs for which there is no vaccine. Its causative agent African swine fever virus (ASFV) is a highly complex enveloped DNA virus encoding more than 150 open reading frames. The antigenicity of ASFV is still unclear at present. In this study, 35 proteins of ASFV were expressed by Escherichia coli, and ELISA was developed for the detection of antibodies against these proteins. p30, p54, and p22 were presented as the major antigens of ASFV, positively reacting with all five clinical ASFV-positive pig sera, and 10 pig sera experimentally infected by ASFV. Five proteins (pB475L, pC129R, pE199L, pE184L, and pK145R) reacted well with ASFV-positive sera. The p30 induced a rapid and strong antibody immune response during ASFV infection. These results will promote the development of subunit vaccines and serum diagnostic methods against ASFV