Geometric Modeling of Cellular Materials for Additive Manufacturing in Biomedical Field: A Review

Advances in additive manufacturing technologies facilitate the fabrication of cellular materials that have tailored functional characteristics. The application of solid freeform fabrication techniques is especially exploited in designing scaffolds for tissue engineering. In this review, firstly, a classification of cellular materials from a geometric point of view is proposed; then, the main approaches on geometric modeling of cellular materials are discussed. Finally, an investigation on porous scaffolds fabricated by additive manufacturing technologies is pointed out. Perspectives in geometric modeling of scaffolds for tissue engineering are also proposed

Set Covering Problem: a computational study of different approaches with CPLEX

Il presente lavoro tratta dell'implementazione di alcuni metodi per la pre-elaborazione e la risoluzione esatta del Set Covering Problem (SCP) con tecniche di Mixed-Integer Linear Programming (MILP). Le tecniche di risoluzione, descritte negli articoli di E. Balas e A. Ho, vengono adattate per operare con un moderno risolutore MILP (CPLEX). Viene descritto anche un metodo originale per pre-elaborare le istanze di SCP.ope

Extra-powerful on the visuo-perceptual space, but variable on the number space: Different effects of optokinetic stimulation in neglect patients

We studied the effects of optokinetic stimulation (OKS; leftward, rightward, control) on the visuo-perceptual and number space, in the same sample, during line bisection and mental number interval bisection tasks. To this end, we tested six patients with right-hemisphere damage and neglect, six patients with right-hemisphere damage but without neglect, and six neurologically healthy participants. In patients with neglect, we found a strong effect of leftward OKS on line bisection, but not on mental number interval bisection. We suggest that OKS influences the number space only under specific conditions

The relationship between Cognitive Reserve and Math Abilities

Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the different degree of impairment in cognitive abilities in aging. The aim of this study is to verify the effect of Cognitive Reserve, as measured by a questionnaire, on a variety of numerical abilities (number comprehension, reading and writing numbers, rules and principles, mental calculations and written calculations), in a group of healthy older people (aged 65-98 years). Sixty older individuals were interviewed with the Cognitive Reserve Index questionnaire (CRIq), and assessed with the Numerical Activities of Daily Living battery (NADL), which included formal tasks on math abilities, an informal test on math, one interview with the participant, and one interview with a relative on the perceived math abilities. We also took into account the years of education, as another proxy for Cognitive Reserve. In the multiple regression analyses on all formal tests, CRIq scores did not significantly predict math performance. Other variables, i.e., years of education and Mini-Mental State Examination score, accounted better for math performance on NADL. Only a subsection of CRIq, CRIq-Working-activity, was found to predict performance on a NADL subtest assessing informal use of math in daily life. These results show that education might better explain abstract math functions in late life than other aspects related to Cognitive Reserve, such as lifestyle or occupational attainment

Questioning Walking Tourism from a Phenomenological Perspective: Epistemological and Methodological Innovations

This article aims to illuminate the overlooked entanglement of space, material practices, affects, and cognitive work emplaced in walking tourism. Walking as a tourism activity is generally practised in the open air away from crowded locations; therefore, it is being encouraged even more in this (post)pandemic era than prior to the pandemic. While walking is often represented as a relatively easy activity in common promotional discourse, this article argues that it is much more complex. It revises the notion of tourist place performance, focusing on walking both as a tourist practice and as a research method that questions multi-sensory and emotional walker engagement. While extensively revisiting literature on walking tourism and the most novel methodological innovations, the article draws from a walking tourism experience undertaken as part of a student trip to demonstrate that the emotions that arise from walkers’ embodied encounters with living, as well as inanimate elements, extend beyond what might be included in a simple focus on landscape “sights”. In conclusion, it is suggested that a phenomenological approach to walking may prove particularly useful for understanding key issues associated with space, place, and tourism mobilities

DeepCSI: Rethinking Wi-Fi Radio Fingerprinting Through MU-MIMO CSI Feedback Deep Learning

We present DeepCSI, a novel approach to Wi-Fi radio fingerprinting (RFP) which leverages standard-compliant beamforming feedback matrices to authenticate MU-MIMO Wi-Fi devices on the move. By capturing unique imperfections in off-the-shelf radio circuitry, RFP techniques can identify wireless devices directly at the physical layer, allowing low-latency low-energy cryptography-free authentication. However, existing Wi-Fi RFP techniques are based on software-defined radio (SDRs), which may ultimately prevent their widespread adoption. Moreover, it is unclear whether existing strategies can work in the presence of MU-MIMO transmitters - a key technology in modern Wi-Fi standards. Conversely from prior work, DeepCSI does not require SDR technologies and can be run on any low-cost Wi-Fi device to authenticate MU-MIMO transmitters. Our key intuition is that imperfections in the transmitter's radio circuitry percolate onto the beamforming feedback matrix, and thus RFP can be performed without explicit channel state information (CSI) computation. DeepCSI is robust to inter-stream and inter-user interference being the beamforming feedback not affected by those phenomena. We extensively evaluate the performance of DeepCSI through a massive data collection campaign performed in the wild with off-the-shelf equipment, where 10 MU-MIMO Wi-Fi radios emit signals in different positions. Experimental results indicate that DeepCSI correctly identifies the transmitter with an accuracy of up to 98%. The identification accuracy remains above 82% when the device moves within the environment. To allow replicability and provide a performance benchmark, we pledge to share the 800 GB datasets - collected in static and, for the first time, dynamic conditions - and the code database with the community.Comment: To be presented at the 42nd IEEE International Conference on Distributed Computing Systems (ICDCS), Bologna, Italy, July 10-13, 202

Biocompatibility and antibacterial properties of zirconium nitride coating on titanium abutments: An in vitro study

Improving soft tissue attachment and reducing bacterial colonization on titanium abutments are key factors for the long-term maintenance of healthy soft and hard peri-implant tissues. This in vitro study was conducted to compare the biocompatibility and antibacterial activity of four different surfaces: uncoated Ti6Al4V, anodized, and coated with titanium nitride or zirconium nitride. Surface topography was investigated with a high-resolution system for measuring surface finishes. Human gingival fibroblast (HGF) adhesion and proliferation were examined using MTT assay, Scanning Electron Microscopy (SEM) imaging, immunofluorescence analysis and real-time PCR for selected target genes. The hemolysis and AMES tests were performed to assess the chemical compounds' blood compatibility and mutagenic potential, respectively. Antibacterial activity was tested against five bacterial strains isolated from the oral cavity (Streptococcus salivarius, S. sanguinis, S. mutans, S. sobrinus, S. oralis), and the percentage of dead bacteria was calculated. Roughness measurements confirmed a substantial similarity between the surfaces and their compatibility with clinical applications. MTT assay, SEM analysis and immunofluorescence staining showed adhesion and proliferation of HGFs cultured on all the examined surfaces. PCR confirmed that HGFs produced extracellular matrix components efficiently on all the surfaces. No hemolytic activity was detected, and the AMES test confirmed the surfaces' clinical safety. For all tested bacterial strains, biofilms grown on the zirconium nitride surface showed a higher percentage of dead bacteria than on the other disks. The titanium nitride surface inactivated bacterial biofilms, too, but to a lesser extent

Sudden hearing loss as an early detector of multiple sclerosis: a systematic review

To evaluate whether Sudden Sensorineural Hearing Loss (S-SNHL) may be an early symptom of Multiple Sclerosis (MS). A systematic review was conducted using the following keywords: "Multiple sclerosis, hearing loss, sudden hearing loss, vertigo, tinnitus, magnetic resonance imaging, otoacoustic emission, auditory brainstem responses, white matter lesions, sensorineural hearing loss, symptoms of MS and otolaryngology, nerve disease and MS". Only the articles that included results of at least one auditory test and MRI were considered. We evaluated the prevalence of SNHL in patients with MS, the presence of different forms of SNHL (S-SNHL and Progressive SNHL (P-SNHL)) and their correlation with the stage of MS, the results of electrophysiological tests, and the location (if any) of MS lesions as detected by white matter hyperintensities in the MRI. We reviewed a total of 47 articles, which included 29 case reports, 6 prospective studies, 6 cohort studies, 4 case-control studies, and 2 retrospective studies. 25% of patients suffered from SNHL. S-SNHL typically occurred in the early stage of the disease (92% of patients) and was the only presenting symptom in 43% of female subjects. Instead, P-SNHL occurred in the late stage of MS (88% of patients). Auditory Brainstem Responses (ABR) were abnormal in all MS patients with S-SNHL. When S-SNHL appeared during the early stage of the disease, MS lesions were found in the brain in 60% of patients and in the Internal Auditory Canal in 40% of patients. ABR remained abnormal after recovery. S-SNHL can be an early manifestation of MS and should always be considered in the differential diagnosis of this condition, especially in women. The pathophysiology can be explained by the involvement of microglia attacking the central and/or peripheral auditory pathways as indicated by WMHs

A new clinical tool for assessing numerical abilities in neurological diseases: numerical activities of daily living

The aim of this study was to build an instrument, the numerical activities of daily living (NADL), designed to identify the specific impairments in numerical functions that may cause problems in everyday life. These impairments go beyond what can be inferred from the available scales evaluating activities of daily living in general, and are not adequately captured by measures of the general deterioration of cognitive functions as assessed by standard clinical instruments like the MMSE and MoCA. We assessed a control group (n = 148) and a patient group affected by a wide variety of neurological conditions (n = 175), with NADL along with IADL, MMSE, and MoCA. The NADL battery was found to have satisfactory construct validity and reliability, across a wide age range. This enabled us to calculate appropriate criteria for impairment that took into account age and education. It was found that neurological patients tended to overestimate their abilities as compared to the judgment made by their caregivers, assessed with objective tests of numerical abilities