Response of Saturn's auroral ionosphere to electron precipitation: Electron density, electron temperature, and electrical conductivity

In the high-latitude regions of Saturn, the ionosphere is strongly coupled to the magnetosphere through the exchange of energy. The influx of energetic particles from Saturn's magnetosphere enhances the ionospheric densities and temperatures, affects the electrodynamical properties of the ionosphere, and contributes to the heating of the thermosphere. It is therefore critical to accurately model the energy deposition of these magnetospheric particles in the upper atmosphere in order to evaluate key ionospheric quantities of the coupled magnetosphere-ionosphere system. We present comprehensive results of ionospheric calculations in the auroral regions of Saturn using our Saturn Thermosphere-Ionosphere Model (STIM). We focus on solar minimum conditions during equinox. The atmospheric conditions are derived from the STIM 3-D General Circulation Model. The ionospheric component is self-consistently coupled to the solar and auroral energy deposition component. The precipitating electrons are assumed to have a Maxwellian distribution in energy with a mean energy E-m and an energy flux Q(0). In the presence of hard electron precipitation (1 < E-m <= 20 keV) with Q(0) > 0.04 mW m(-2), the ionospheric conductances are found to be proportional to the square root of the energy flux, but the response of the ionosphere is not instantaneous and a time delay needs to be applied to Q(0) when estimating the conductances. In the presence of soft electron precipitation (E-m < 500 eV) with Q(0) <= 0.2 mW m(-2), the ionospheric conductances at noon are found to be primarily driven by the Sun. However, soft auroral electrons are efficient at increasing the ionospheric total electron content and at heating the thermal electron population

Characterization of a Double Mesospheric Bore Over Europe

Observations of a pair of mesospheric bore disturbances that propagated through the nighttime mesosphere over Europe are presented. The observations were made at the Padua Observatory, Asiago (45.9\ub0N, 11.5\ub0E), by the Boston University all-sky imager on 11 March 2013. The bores appeared over the northwest horizon, approximately 30 min apart, and propagated toward the southeast. Using additional satellite and radar data, we present evidence indicating the bores originated in the mesosphere from a single, larger-scale mesospheric disturbance propagating through the mesopause region. Furthermore, the large-scale mesospheric disturbance appeared to be associated with an intense weather disturbance that moved southeastward over the United Kingdom and western Europe during 10 and 11 March

Comparative ionospheres: terrestrial and giant planets

The study of planetary ionospheres within our solar system offers a variety of settings to probe mechanisms of photo-ionization, chemical loss, and plasma transport. Ionospheres are a minor component of upper atmospheres, and thus their mix of ions observed depends on the neutral gas composition of their parent atmospheres. The same solar irradiance (x-rays and extreme-ultra-violet vs. wavelength) impinges upon each of these atmospheres, with solar flux magnitudes changed only by the inverse square of distance from the Sun. If all planets had the same neutral atmosphere—with ionospheres governed by photochemical equilibrium (production = loss)—their peak electron densities would decrease as the inverse of distance from the Sun, and any changes in solar output would exhibit coherent effects throughout the solar system. Here we examine the outer planet with the most observations of its ionosphere (Saturn) and compare its patterns of electron density with those at Earth under the same-day solar conditions. We show that, while the average magnitudes of the major layers of molecular ions at Earth and Saturn are approximately in accord with distance effects, only minor correlations exist between solar effects and day-to-day electron densities. This is in marked contrast to the strong correlations found between the ionospheres of Earth and Mars. Moreover, the variability observed for Saturn's ionosphere (maximum electron density and total electron content) is much larger than found at Earth and Mars. With solar irradiance changes far too small to cause such effects, we use model results to explore the roles of other agents. We find that water sources from Enceladus at low latitudes, and ‘ring rain’ at middle latitudes, contribute substantially to variability via water ion chemistry. Thermospheric winds and electrodynamics generated at auroral latitudes are suggested causes of high latitude ionospheric variability, but remain inconclusive due to the lack of relevant observations

Magnetosphere-atmosphere coupling at Saturn: 1-Response of thermosphere and ionosphere to steady state polar forcing

We present comprehensive calculations of the steady state response of Saturn’s coupled thermosphere–ionosphere to forcing by solar radiation, magnetospheric energetic electron precipitation and high latitude electric fields caused by sub-corotation of magnetospheric plasma. Significant additions to the physical processes calculated in our Saturn Thermosphere Ionosphere General Circulation Model (STIM–GCM) include the comprehensive and self-consistent treatment of neutral–ion dynamical coupling and the use of self-consistently calculated rates of plasma production from incident energetic electrons. Our simulations successfully reproduce the observed high latitude temperatures as well as the latitudinal variations of ionospheric peak electron densities that have been observed by the Cassini Radio Science Subsystem experiment (RSS). We find magnetospheric energy deposition to strongly control the flow of mass and energy in the high and mid-latitude thermosphere and thermospheric dynamics to play a crucial role in driving this flow, highlighting the importance of including dynamics in any high latitude energy balance studies on Saturn and other Gas Giants. By relating observed View the MathML sourceH3+ column emissions and temperatures to the same quantities inferred from simulated atmosphere profiles we identify a potential method of better constraining the still unknown abundance of vibrationally excited H2 which strongly affects the View the MathML sourceH3+ densities. Our calculations also suggest that local time variability in View the MathML sourceH3+ column emission flux may be largely driven by local time changes of View the MathML sourceH3+ densities rather than temperatures. By exploring the parameter space of possible high latitude electric field strengths and incident energetic electron fluxes, we determine the response of thermospheric polar temperatures to a range of these magnetospheric forcing parameters, illustrating that 10 keV electron fluxes of 0.1–1.2 mW m−2 in combination with electric field strengths of 80–100 mV m−1 produce View the MathML sourceH3+ emissions consistent with observations. Our calculations highlight the importance of considering thermospheric temperatures as one of the constraints when examining the state of Saturn’s magnetosphere and its coupling to the upper atmosphere

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vulnerable to environmental insults, cellular protein imbalance and targeted pharmaceuticals. Yet, mechanisms that cells deploy to counteract inhibition of this central regulator are little understood. To find such mechanisms, we reduced flux through the proteasome to the point of toxicity with specific inhibitors and performed genome-wide screens for mutations that allowed cells to survive. Counter to expectation, reducing expression of individual subunits of the proteasome's 19S regulatory complex increased survival. Strong 19S reduction was cytotoxic but modest reduction protected cells from inhibitors. Protection was accompanied by an increased ratio of 20S to 26S proteasomes, preservation of protein degradation capacity and reduced proteotoxic stress. While compromise of 19S function can have a fitness cost under basal conditions, it provided a powerful survival advantage when proteasome function was impaired. This means of rebalancing proteostasis is conserved from yeast to humans

Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response

Dramatic rise of mutators has been found to accompany adaptation of bacteria in response to many kinds of stress. Two views on the evolutionary origin of this phenomenon emerged: the pleiotropic hypothesis positing that it is a byproduct of environmental stress or other specific stress response mechanisms and the second order selection which states that mutators hitchhike to fixation with unrelated beneficial alleles. Conventional population genetics models could not fully resolve this controversy because they are based on certain assumptions about fitness landscape. Here we address this problem using a microscopic multiscale model, which couples physically realistic molecular descriptions of proteins and their interactions with population genetics of carrier organisms without assuming any a priori fitness landscape. We found that both pleiotropy and second order selection play a crucial role at different stages of adaptation: the supply of mutators is provided through destabilization of error correction complexes or fluctuations of production levels of prototypic mismatch repair proteins (pleiotropic effects), while rise and fixation of mutators occur when there is a sufficient supply of beneficial mutations in replication-controlling genes. This general mechanism assures a robust and reliable adaptation of organisms to unforeseen challenges. This study highlights physical principles underlying physical biological mechanisms of stress response and adaptation

Anthropogenic Space Weather

Anthropogenic effects on the space environment started in the late 19th century and reached their peak in the 1960s when high-altitude nuclear explosions were carried out by the USA and the Soviet Union. These explosions created artificial radiation belts near Earth that resulted in major damages to several satellites. Another, unexpected impact of the high-altitude nuclear tests was the electromagnetic pulse (EMP) that can have devastating effects over a large geographic area (as large as the continental United States). Other anthropogenic impacts on the space environment include chemical release ex- periments, high-frequency wave heating of the ionosphere and the interaction of VLF waves with the radiation belts. This paper reviews the fundamental physical process behind these phenomena and discusses the observations of their impacts.Comment: 71 pages, 35 figure

Observations of quiet-time moderate midlatitude L-band scintillation in association with plasma bubbles

Observations of moderate night time amplitude scintillation on the GPS L1C/A signal were recorded at the midlatitude station of Nicosia, corresponding geographic latitude and longitude of 35.18˚N and 33.38˚E respectively, on a geomagnetically quiet day. The variations of slant total electron content (STEC) and amplitude scintillation index (S4) on the night of June 12, 2014, indicate the presence of electron density depletions accompanying scintillation occurrence. The estimated apparent horizontal drift velocity and propagation direction of the plasma depletions are consistent with those observed for the equatorial plasma bubbles, thus suggesting that the moderate amplitude L-band scintillation observed over Nicosia may be associated with the extension of such plasma bubbles. The L-band scintillation occurrence was concurrent with the observations of range spread F on the ionograms recorded by the digisonde at Nicosia. The height–time–intensity plot generated using the ionogram data also showed features which can be attributed to off-angle reflections from electron density depletions, thus corroborating the STEC observations. This observation suggests that the midlatitude ionosphere is more active even during geomagnetically quiet days than previously thought and that further studies are necessary. This is particularly relevant for the GNSS user community and related applications

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator Heat-Shock Factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of malignancy. HSF1 drives a transcriptional program in CAFs that complements, yet is completely different from, the program it drives in adjacent cancer cells. This CAF program is uniquely structured to support the malignant potential of cancer cells in a non-cell-autonomous way. Two central stromal signaling molecules—TGFβ and stromal-derived factor 1 (SDF1) – play a critical role. In early stage breast and lung cancer, high stromal HSF1 activation is strongly associated with poor patient outcome. Thus, tumors co-opt the ancient survival functions of HSF1 to orchestrate malignancy in both cell-autonomous and non-cell-autonomous ways, with far-reaching therapeutic implications