Occupational Therapy Strategies for Postural Orthostatic Tachycardia Syndrome

Effectiveness of occupational therapy strategies with adults with postural orthostatic tachycardia syndrome

Black, Brown, and Powerful: Freedom Dreams in Unequal Cities

In April 2018, the Institute on Inequality and Democracy convened scholars, activists, policy advocates, community residents, and nonprofit workers to share and discuss research and action pertaining to processes of inequality in Los Angeles. We sought to shed light on the entangled structures of oppression, including urban displacement, housing precarity, racialized policing, criminal justice debt, forced labor, and the mass supervision and control of youth. Through keynote talks, group dialogue, and workshops, we analyzed how in Los Angeles, and elsewhere, black and brown communities face multiple forms of banishment and exploitation ranging from the criminalization of poverty to institutionalized theft.The question of racial banishment has been an important one for the Institute since its inauguration two years ago. This year though, amidst the troubled times of Trumpism, we wanted to shift our focus from banishment to freedom. In the reports that follow, you will find many examples of what Robin D.G. Kelley, a key presence at the Institute, has famously called “freedom dreams.” Located in, and thinking from South Central Los Angeles, the event’s participants provide insight into organizing frameworks and resistance strategies that challenge exclusion and refuse subordination. From tenant organizing to debtors’ unions, from underground scholars to educational reparations, visions of freedom abound. The Institute on Inequality and Democracy is convinced that university-based research can, and must, support such freedom dreams. Such partnership – between the public university and social justice movements – requires careful attention to the difficult task of decolonizing the university. This mandate is evident throughout this collection of reports. There is no easy alliance between academic power and banished communities; there is no obvious solidarity between urban plans and freedom dreams. This event was intended to be a step towards building such alliances, especially by reconstructing the curriculum and canon of knowledge

Building First‑Year Medical Students’ Skills in Finding, Evaluating, and Visualizing Health Information Through a “Debunking Medical Myths” Curricular Module

To provide an online service learning opportunity for medical students during the COVID-19 pandemic, medical faculty and librarians developed and implemented a “Debunking Medical Myths” module in which students learned to search for emerging medical literature, evaluate evidence, and use that evidence to create an infographics debunking a COVID-19-related myth for a non-medical audience. The resultant infographics are visually appealing and designed to make complex health information easy to understand. The module was well-received by students, who demonstrated a nuanced understanding of the use of infographics to convey health information, and students’ work was evaluated highly by community members

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P. berghei ANKA infection have not been investigated, and it is not known whether IFN-γ production by a single cell type in isolation can induce cerebral pathology. In this study, using IFN-γ reporter mice, we show that NK cells dominate the IFN-γ response during the early stages of infection in the brain, but not in the spleen, before being replaced by CD4(+) and CD8(+) T cells. Importantly, we demonstrate that IFN-γ-producing CD4(+) T cells, but not innate or CD8(+) T cells, can promote the development of ECM in normally resistant IFN-γ(-/-) mice infected with P. berghei ANKA. Adoptively transferred wild-type CD4(+) T cells accumulate within the spleen, lung, and brain of IFN-γ(-/-) mice and induce ECM through active IFN-γ secretion, which increases the accumulation of endogenous IFN-γ(-/-) CD8(+) T cells within the brain. Depletion of endogenous IFN-γ(-/-) CD8(+) T cells abrogates the ability of wild-type CD4(+) T cells to promote ECM. Finally, we show that IFN-γ production, specifically by CD4(+) T cells, is sufficient to induce expression of CXCL9 and CXCL10 within the brain, providing a mechanistic basis for the enhanced CD8(+) T cell accumulation. To our knowledge, these observations demonstrate, for the first time, the importance of and pathways by which IFN-γ-producing CD4(+) T cells promote the development of ECM during P. berghei ANKA infection

Control interno de la Corporación Británika del Perú- Nuevo Chimbote, 2021

El presente trabajo tuvo como objetivo general; Evaluar el control interno de la Corporación Británika del Perú Nuevo Chimbote, 2021 El tipo de investigación es descriptiva y el diseño de investigación es no experimental. Por otra parte, la población estaba integrada por los colaboradores que conforman la Corporación Británika del Perú que en este caso fue 40 y para la muestra es igual a la población y por ser pequeña es la misma. Las técnicas e instrumentos utilizados fueron la ficha de observación y el cuestionario Se pudo concluir que la “Corporación Británika del Perú” no cuenta con propósitos estratégicos redactados, con un reglamento de ética profesional aprobado y difundido, tampoco cuenta con un MOF, ROF, MAPRO, no cuenta con un PEI, POI. No tiene una programación por departamento. Se observó que no existen políticas de desarrollo para el personal, carecen de normas, reglas y manuales de funcionamiento, no se ha capacitado a los trabajadores respectos a las pocas normas de control que manejan

Longitudinal Professional Identity Development Amongst Medical Students

Abstract Title: Longitudinal Professional Identity Development Amongst Medical Students Background: Professional development is a core competency for medical student education. A standardized model for assessment of student longitudinal professional identity development will allow medical schools to better implement interventions. Methods: To assess professional development at a large, Midwest, allopathic medical school, a survey with seven statements regarding professional development was created. The statements encompassed domains of mentorship, communication skills, professionalism, and innovation and asked students to rank each statement from 1-5 (1 - highly deficient, 5 - highly proficient). The online, anonymous survey was emailed to all students (n = 1154) over a 2 month time period. Results: 319 (27.6%) surveys were completed. Responses between year 1-2 and year 3-4 showed a unanimous increase in average proficiency across all 7 statements. Year 3-4 had a significant increase in overall proficiency (p Conclusion: Although professional identity development follows an overall upward trend, year 3 is a vulnerable period for professional identity development. While increased accessibility to advising is needed in all four years, it is even more necessary in year 3. The power of the study is limited by the number of responses

Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix

The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for lung tissue regeneration and subsequent implantation. However, finding a reliable cell source and the ability to scale up for recellularization of the lung scaffold still remain significant challenges. To explore the possibility of regeneration of human lung tissue from stem cells in vitro, populations of lung progenitor cells were generated from human iPSCs. To explore the feasibility of producing engineered lungs from stem cells, we repopulated decellularized human lung and rat lungs with iPSC‐derived epithelial progenitor cells. The iPSCs‐derived epithelial progenitor cells lined the decellularized human lung and expressed most of the epithelial markers when were cultured in a lung bioreactor system. In decellularized rat lungs, these human‐derived cells attach and proliferate in a manner similar to what was observed in the decellularized human lung. Our results suggest that repopulation of lung matrix with iPSC‐derived lung epithelial cells may be a viable strategy for human lung regeneration and represents an important early step toward translation of this technology.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/1/term2589.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/2/term2589_am.pd