23 research outputs found
Orbit optimization for ASTROD-GW and its time delay interferometry with two arms using CGC ephemeris
ASTROD-GW (ASTROD [Astrodynamical Space Test of Relativity using Optical
Devices] optimized for Gravitation Wave detection) is an optimization of ASTROD
to focus on the goal of detection of gravitation waves. The detection
sensitivity is shifted 52 times toward larger wavelength compared to that of
LISA. The mission orbits of the 3 spacecraft forming a nearly equilateral
triangular array are chosen to be near the Sun-Earth Lagrange points L3, L4 and
L5. The 3 spacecraft range interferometrically with one another with arm length
about 260 million kilometers. In order to attain the requisite sensitivity for
ASTROD-GW, laser frequency noise must be suppressed below the secondary noises
such as the optical path noise, acceleration noise etc. For suppressing laser
frequency noise, we need to use time delay interferometry (TDI) to match the
two different optical paths (times of travel). Since planets and other
solar-system bodies perturb the orbits of ASTROD-GW spacecraft and affect the
(TDI), we simulate the time delay numerically using CGC 2.7 ephemeris
framework. To conform to the ASTROD-GW planning, we work out a set of 20-year
optimized mission orbits of ASTROD-GW spacecraft starting at June 21, 2028, and
calculate the residual optical path differences in the first and second
generation TDI for one-detector case. In our optimized mission orbits for 20
years, changes of arm length are less than 0.0003 AU; the relative Doppler
velocities are less than 3m/s. All the second generation TDI for one-detector
case satisfies the ASTROD-GW requirement.Comment: 17 pages, 7 figures, 1 tabl
Numerical simulation of time delay interferometry for eLISA/NGO
eLISA/NGO is a new gravitational wave detection proposal with arm length of
10^6 km and one interferometer down-scaled from LISA. Just like LISA and
ASTROD-GW, in order to attain the requisite sensitivity for eLISA/NGO, laser
frequency noise must be suppressed to below the secondary noises such as the
optical path noise, acceleration noise etc. In previous papers, we have
performed the numerical simulation of the time delay interferometry (TDI) for
LISA and ASTROD-GW with one arm dysfunctional by using the CGC 2.7 ephemeris.
The results are well below their respective limits which the laser frequency
noise is required to be suppressed. In this paper, we follow the same procedure
to simulate the time delay interferometry numerically. To do this, we work out
a set of 1000-day optimized mission orbits of the eLISA/NGO spacecraft starting
at January 1st, 2021 using the CGC 2.7 ephemeris framework. We then use the
numerical method to calculate the residual optical path differences in the
second-generation TDI solutions as in our previous papers. The maximum path
length difference, for all configurations calculated, is below 13 mm (43 ps).
It is well below the limit which the laser frequency noise is required to be
suppressed for eLISA/NGO. We compare and discuss the resulting differences due
to the different arm lengths for various mission proposals -- eLISA/NGO, an
NGO-LISA-type mission with a nominal arm length of 2 x 10^6 km, LISA and
ASTROD-GW.Comment: 17 pages, 13 figures, 3 tables, minor changes in description to match
the accepted version of Classical and Quantum Gravity. arXiv admin note: text
overlap with arXiv:1102.496
Orbital effects of a monochromatic plane gravitational wave with ultra-low frequency incident on a gravitationally bound two-body system
We analytically compute the long-term orbital variations of a test particle
orbiting a central body acted upon by an incident monochromatic plane
gravitational wave. We assume that the characteristic size of the perturbed
two-body system is much smaller than the wavelength of the wave. Moreover, we
also suppose that the wave's frequency is much smaller than the particle's
orbital one. We make neither a priori assumptions about the direction of the
wavevector nor on the orbital geometry of the planet. We find that, while the
semi-major axis is left unaffected, the eccentricity, the inclination, the
longitude of the ascending node, the longitude of pericenter and the mean
anomaly undergo non-vanishing long-term changes. They are not secular trends
because of the slow modulation introduced by the tidal matrix coefficients and
by the orbital elements themselves. They could be useful to indepenedently
constrain the ultra-low frequency waves which may have been indirectly detected
in the BICEP2 experiment. Our calculation holds, in general, for any
gravitationally bound two-body system whose characteristic frequency is much
larger than the frequency of the external wave. It is also valid for a generic
perturbation of tidal type with constant coefficients over timescales of the
order of the orbital period of the perturbed particle.Comment: LaTex2e, 24 pages, no figures, no tables. Changes suggested by the
referees include
Synthetic Nanoparticles for Vaccines and Immunotherapy
The immune system plays a critical role in our health. No other component of human physiology plays a decisive role in as diverse an array of maladies, from deadly diseases with which we are all familiar to equally terrible esoteric conditions: HIV, malaria, pneumococcal and influenza infections; cancer; atherosclerosis; autoimmune diseases such
as lupus, diabetes, and multiple sclerosis. The importance of understanding the function of the immune system and learning how to modulate immunity to protect against or treat disease thus cannot be overstated. Fortunately, we are entering an exciting era where the
science of immunology is defining pathways for the rational manipulation of the immune system at the cellular and molecular level, and this understanding is leading to dramatic advances in the clinic that are transforming the future of medicine.1,2 These initial advances are being made primarily through biologic drugs– recombinant proteins (especially antibodies) or patient-derived cell therapies– but exciting data from preclinical studies suggest that a marriage of approaches based in biotechnology with the materials science and chemistry of nanomaterials, especially nanoparticles, could enable more effective and safer immune engineering strategies. This review will examine these nanoparticle-based strategies to immune modulation in detail, and discuss the promise and outstanding challenges facing the field of immune engineering from a chemical biology/materials engineering perspectiveNational Institutes of Health (U.S.) (Grants AI111860, CA174795, CA172164, AI091693, and AI095109)United States. Department of Defense (W911NF-13-D-0001 and Awards W911NF-07-D-0004
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts