35 research outputs found

    International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

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    Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

    The changing paradigm: estrogen receptor α recognition on DNA and within the dynamic nature of nucleosomes

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    Effects of benefit finding, social support and caregiving on youth adjustment in a parental illness context

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    Social support and benefit finding are two related processes that may protect youth from the adverse effects of caring for an ill parent. The primary purpose of this study was to test a mediational model proposal that benefit finding mediates the effects of social support and caregiving on youth adjustment in the context of parental illness. Given the dearth of research on benefit finding in the youth caregiving field, an additional aim was to further clarify the benefit finding construct in the parental illness context. A total of 428 Australian youth (mean age 12.77 years) who had a parent with a serious health problem completed a questionnaire. Exploration of the benefit finding construct showed that it was unidimensional, relevant to youth caregivers, unrelated to measured demographics, but highly linked to caregiving demands and engagement. Results from path modelling analysis supported the mediational model proposal that benefit finding mediates the effects of social support and caregiving on youth adjustment. While caregiving responsibilities in general has a detrimental effect on adjustment, a small counter-balancing indirect effect was detected via the role of increased benefit finding due to caregiving responsibilities. Most of the benefit finding research in youth has been conducted in the context of trauma, where parental support is a significant protective factor. This study makes an important contribution to understanding benefit finding and social support processes in the context of a chronic stressor where one of the usual sources (parents) of significant coping support is limited
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