Gabapentin for pain management after osmotic dilator insertion and prior to dilation and evacuation: A randomized controlled trial.

ObjectiveTo evaluate if gabapentin 600 mg reduces pain after osmotic dilator placement the day before a dilation and evacuation (D&E) procedure.Study designWe conducted a double-blind, placebo-controlled, randomized (stratified by vaginal parity) trial among women undergoing osmotic dilator placement before D&E at 15-23 5/7 weeks gestation. Subjects received gabapentin 600 mg or placebo 30 min before dilator placement, with re-dosing 8 h later. We assessed pain after dilator placement using a numeric rating scale (NRS; scale 0-10) at 5 min, 2, 4, and 8 h, and at presentation for D&E. The primary outcome was median NRS pain score change from baseline to 8 h after dilator placement. Secondary outcomes included gabapentin-related side effects and analgesic use.ResultsOf 121 randomized women, we excluded three subjects (allergic reaction [placebo], randomization error, no NRS data), leaving 60 gabapentin and 58 placebo subjects. Of 110 (93%) women who provided 8-hour data, median pain score changes from baseline did not differ between gabapentin and placebo groups overall (2 vs. 2.5, p = 0.52), in vaginally nulliparous women (2 vs. 4, p = 0.10) or in parous women (2 vs. 1.5, p = 0.37). We found no statistically significant differences in median pain score change from baseline to any timepoint overall or when stratified by parity. Beginning at 2 h after dilator placement, more gabapentin than placebo users experienced dizziness (29/53[55%] vs. 11/53[21%], p = 0.001) and tiredness (34/54[63%] vs. 17/54[31%], p = 0.002). The proportion of women using narcotics did not differ between gabapentin (35/60[58%]) or placebo (40/58[69%]) users (p = 0.26).ConclusionsGabapentin does not reduce pain with overnight osmotic dilator placement prior to D&E and causes drug-related side effects.Implications statementWomen experience pain, mostly mild to moderate, with overnight cervical dilator placement at 15-23 5/7 weeks gestation. About 2/3 of women will use a limited quantity of narcotics if provided. Gabapentin does not decrease the pain with or following dilator placement and does not decrease narcotic use

Filaments in Galactic Winds Driven by Young Stellar Clusters

The starburst galaxy M82 shows a system of H$\alpha$-emitting filaments which extend to each side of the galactic disk. We model these filaments as the result of the interaction between the winds from a distribution of Super Stellar Clusters (SSCs). We first derive the condition necessary for producing a radiative interaction between the cluster winds (a condition which is met by the SSC distribution of M82). We then compute 3D simulations for SSC wind distributions which satisfy the condition for a radiative interaction, and also for distributions which do not satisfy this condition. We find that the highly radiative models, that result from the interaction of high metallicity cluster winds, produce a structure of H$\alpha$ emitting filaments, which qualitatively agrees with the observations of the M82, while the non-radiative SSC wind interaction models do not produce filamentary structures. Therefore, our criterion for radiative interactions (which depends on the mass loss rate and the terminal velocity of the SSC winds, and the mean separation between SSCs) can be used to predict whether or not an observed galaxy should have associated H$\alpha$ emitting filaments.Comment: 10 pages, 6 Figures. ApJ Accepted, August 7, 200

Aspectos da associação micorrízica em plantas forrageiras (Bauhinia cheilanta e Dolichos lablab - Fabacea): simbiose e eficiência no crescimento vegetal sob condições semi-áridas.

Os objetivos desse trabalho foram avaliar a condição micorrízica e identificar espécies de FMA presentes nas rizosfera das plantas forrageiras: mororó (Bauhinia cheilanta) e lablab (Dolichos lablab), em condições semi-áridas, e selecionar espécies de FMA eficientes em promover a sobrevivência, o crescimento e o teor nutricional de plantas forrageiras em dois tipos de solo representativos da região do vale do submédio São Francisco

Ultracold heteronuclear molecules and ferroelectric superfluids

We analyze the possibility of a ferroelectric transition in heteronuclear molecules consisting of Bose-Bose, Bose-Fermi or Fermi-Fermi atom pairs. This transition is characterized by the appearance of a spontaneous electric polarization below a critical temperature. We discuss the existence of a ferroelectric Fermi liquid phase for Fermi molecules and the existence of a ferroelectric superfluid phase for Bose molecules characterized by the coexistence of ferroelectric and superfluid orders. Lastly, we propose an experiment to detect ferroelectric correlations through the observation of coherent dipole radiation pulses during time of flight.Comment: 4 pages and 3 figure

Estudos da ocorrência de fungos micorrizicos arbusculares e do potencial infectivo em espécies nativas da caatinga, na região de Petrolina, Pernambuco

O objetivo deste trabalho foi ampliar os conhecimentos sobre a associação micorrizica (número de glomerosporos, potencial de infectividade do solo, percentual de colonização e diversidade de FMA) em plantas nativas da caatinga

Dirac-like Monopoles in Three Dimensions and Their Possible Influences on the Dynamics of Particles

Dirac-like monopoles are studied in three-dimensional Abelian Maxwell and Maxwell-Chern-Simons models. Their scalar nature is highlighted and discussed through a dimensional reduction of four-dimensional electrodynamics with electric and magnetic sources. Some general properties and similarities of them when are considered in Minkowski or Euclidian space are mentioned. However, by virtue of the structure of the space-time in which they are considered a number of differences among them take place. Furthermore, we pay attention to some consequences of these objects when acting upon usual particles. Among other subjects, special attention is given to the study of a Lorentz-violating non-minimal coupling between neutral fermions and the field generated by a monopole alone. In addition, an analogue of the Aharonov-Casher effect is discussed in this framework.Comment: 20 pages. Latex format. No figures. Accepted for publication in Phys. Rev.