29 research outputs found
Liposome‐containing mechanoresponsive hydrogels
The direct injection of a drug into a joint can relieve osteoarthritic pain for a short period of time. The problem is that the drug will not stay at the allocated location. Therefore, a proof-of-concept in situ is designed forming hydrogel containing liposomes that are covalently linked to the hydrogel network. When the liposomes are filled with a cargo, the formed hydrogel is thus loaded with this cargo, too. Due to the link between the hydrogel and the liposomes, a compression or other mechanical force applied to the hydrogel will rupture the liposomes and release a small percentage of the cargo. Overall, a long-term intra-articular drug release is feasible
An integrated framework for optimizing sculptured surface CNC tool paths based on direct software object evaluation and viral intelligence
Vertical transportation systems embedded on shuffled frog leaping algorithm for manufacturing optimisation problems in industries
An adaptive cuckoo optimization algorithm for system design optimization under failure dependencies
Cost minimization of repairable systems subject to availability constraints using efficient cuckoo optimization algorithm
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