Correlation between nutritional status and lung disease in cystic fibrosis

Cistična je fibroza autosomno recesivna nasljedna multisistemna bolest od koje se u Hrvatskoj danas liječi oko 150 bolesnika. Ponajviše pogađa probavni i dišni sustav, stoga su plućna funkcija ( FEV1 - forsirani ekspiratorni volumen u 1 sekundi, % očekivane vrijednosti) i uhranjenost najčešće korišteni parametri za procjenu stanja bolesti. Plućna je funkcija osnovni prediktor smrti te je dugoročno očuvanje plućne funkcije od životne važnosti za oboljele od cistične fibroze. ----- Cilj ove presječne studije bio je dobiti relevantne podatke za oboljele od cistične fibroze u Hrvatskoj te opisati eventualnu povezanost uhranjenosti i plućne funkcije, na što upućuju brojna dosadašnja istraživanja. U istraživanje je uključeno 39 ispitanika starijih od 6 godina (raspon dobi 6 g – 30 g 11 mj.) koji su se tokom 2015. liječili u KBC-u Zagreb. Analizirana je njihova dob, plućna funkcija i prisustvo kronične kolonizacije dišnog puta s Pseudomonasom aeruginosa. Uhranjenost ispitanika mlađih od 19 godina (N=28) zadovoljavajuća je uz medijan 46,55 percentila BMFA (eng. body mass index for age, indeks tjelesne mase za dob). U skupini bolesnika starijih od 19 godina medijan ITM (indeks tjelesne mase) iznosi 21. Plućna funkcija u cijelom promatranom uzorku značajno pada s dobi (snažna negativna korelacija FEV1 % očekivane vrijednosti i dobi, Spearman r=- 0,713, p<0,0001). Također je utvrđena statistički značajno lošija plućna funkcija (Mann-Whitney p=0,0019) u skupini bolesnika kronično koloniziranih s Pseudomonasom aeruginosa (N= 18, prosječan FEV1 61%) u odnosu na nekolonizirane (N = 21, prosječan FEV1 91,6%). U skupini bolesnika mlađih od 19 godina postoji i statistički značajna pozitivna korelacija uhranjenosti i plućne funkcije (Spearman r=0,409, p=0,031), što se nije potvrdilo u bolesnika starijih od 19 g, vjerojatno zbog malog uzorka velike varijabilnosti. ----- Zaključno, rezultati ukazuju na važnost nutricionističke potpore u cističnoj fibrozi u svim dobnim skupinama, a sa ciljem što duljeg održanja dobre plućne funkcije. Važno je o ovoj povezanosti osvijestiti medicinsko osoblje, ali i bolesnike same s obzirom da mogu aktivno utjecati na vlastitu uhranjenost.Cystic fibrosis is an autosomal recessive inherited multisystem disease recognized in about 150 patients today in Croatia. It mainly affects the digestive and respiratory system, so the pulmonary function (FEV1 - forced expiratory volume in 1 second, % predicted) and nutritional status are the most commonly used parameters to assess the state of the disease. Pulmonary function is a primary predictor of mortality and long - term preservation of lung function is of vital importance for patients with cystic fibrosis. ----- The aim of this cross-sectional study was to obtain relevant information for patients with cystic fibrosis in Croatia and describe a possible connection between nutritional status and lung function, as indicated in numerous previous studies. This study included 39 patients aged 6 years and older (age range 6 g - 30 years 11 months) who were treated at the University Hospital Center Zagreb in 2015. Age, pulmonary function and the presence of chronic Pseudomonas aeruginosa colonization in the airways were analyzed. Nutritional status of patients under the age of 19 (N = 28) is satisfactory with median BMFA (body mass index for age) of 46.55 percentile. In patients aged 19 years and older, the median BMI (body mass index) is 21. In the whole study group pulmonary function significantly decreases with age (strong negative correlation between FEV1 % predicted and age, Spearman r = - 0.713, p <0.0001). Statistically significant (Mann-Whitney p = 0.0019) worse lung function was found in patients chronically colonized with Pseudomonas aeruginosa (n = 18, mean FEV1 61%) when compared to those who were not colonized (N = 21, mean FEV1 91.6 %). In the group of patients under the age of 19 there is a statistically significant positive correlation between nutritional status and lung function (Spearman r = 0.409, p = 0.031), which was not confirmed in patients aged 19 and older, probably due to a small sample with large variability. In conclusion, these results indicate the importance of nutritional support in cystic fibrosis in all age groups, with the aim of maintaining good lung function as long as possible. It is important to raise awareness of this link among medical staff but also the patients themselves, as they can actively influence their own nutritional status

Correlation between nutritional status and lung disease in cystic fibrosis

Cistična je fibroza autosomno recesivna nasljedna multisistemna bolest od koje se u Hrvatskoj danas liječi oko 150 bolesnika. Ponajviše pogađa probavni i dišni sustav, stoga su plućna funkcija ( FEV1 - forsirani ekspiratorni volumen u 1 sekundi, % očekivane vrijednosti) i uhranjenost najčešće korišteni parametri za procjenu stanja bolesti. Plućna je funkcija osnovni prediktor smrti te je dugoročno očuvanje plućne funkcije od životne važnosti za oboljele od cistične fibroze. ----- Cilj ove presječne studije bio je dobiti relevantne podatke za oboljele od cistične fibroze u Hrvatskoj te opisati eventualnu povezanost uhranjenosti i plućne funkcije, na što upućuju brojna dosadašnja istraživanja. U istraživanje je uključeno 39 ispitanika starijih od 6 godina (raspon dobi 6 g – 30 g 11 mj.) koji su se tokom 2015. liječili u KBC-u Zagreb. Analizirana je njihova dob, plućna funkcija i prisustvo kronične kolonizacije dišnog puta s Pseudomonasom aeruginosa. Uhranjenost ispitanika mlađih od 19 godina (N=28) zadovoljavajuća je uz medijan 46,55 percentila BMFA (eng. body mass index for age, indeks tjelesne mase za dob). U skupini bolesnika starijih od 19 godina medijan ITM (indeks tjelesne mase) iznosi 21. Plućna funkcija u cijelom promatranom uzorku značajno pada s dobi (snažna negativna korelacija FEV1 % očekivane vrijednosti i dobi, Spearman r=- 0,713, p<0,0001). Također je utvrđena statistički značajno lošija plućna funkcija (Mann-Whitney p=0,0019) u skupini bolesnika kronično koloniziranih s Pseudomonasom aeruginosa (N= 18, prosječan FEV1 61%) u odnosu na nekolonizirane (N = 21, prosječan FEV1 91,6%). U skupini bolesnika mlađih od 19 godina postoji i statistički značajna pozitivna korelacija uhranjenosti i plućne funkcije (Spearman r=0,409, p=0,031), što se nije potvrdilo u bolesnika starijih od 19 g, vjerojatno zbog malog uzorka velike varijabilnosti. ----- Zaključno, rezultati ukazuju na važnost nutricionističke potpore u cističnoj fibrozi u svim dobnim skupinama, a sa ciljem što duljeg održanja dobre plućne funkcije. Važno je o ovoj povezanosti osvijestiti medicinsko osoblje, ali i bolesnike same s obzirom da mogu aktivno utjecati na vlastitu uhranjenost.Cystic fibrosis is an autosomal recessive inherited multisystem disease recognized in about 150 patients today in Croatia. It mainly affects the digestive and respiratory system, so the pulmonary function (FEV1 - forced expiratory volume in 1 second, % predicted) and nutritional status are the most commonly used parameters to assess the state of the disease. Pulmonary function is a primary predictor of mortality and long - term preservation of lung function is of vital importance for patients with cystic fibrosis. ----- The aim of this cross-sectional study was to obtain relevant information for patients with cystic fibrosis in Croatia and describe a possible connection between nutritional status and lung function, as indicated in numerous previous studies. This study included 39 patients aged 6 years and older (age range 6 g - 30 years 11 months) who were treated at the University Hospital Center Zagreb in 2015. Age, pulmonary function and the presence of chronic Pseudomonas aeruginosa colonization in the airways were analyzed. Nutritional status of patients under the age of 19 (N = 28) is satisfactory with median BMFA (body mass index for age) of 46.55 percentile. In patients aged 19 years and older, the median BMI (body mass index) is 21. In the whole study group pulmonary function significantly decreases with age (strong negative correlation between FEV1 % predicted and age, Spearman r = - 0.713, p <0.0001). Statistically significant (Mann-Whitney p = 0.0019) worse lung function was found in patients chronically colonized with Pseudomonas aeruginosa (n = 18, mean FEV1 61%) when compared to those who were not colonized (N = 21, mean FEV1 91.6 %). In the group of patients under the age of 19 there is a statistically significant positive correlation between nutritional status and lung function (Spearman r = 0.409, p = 0.031), which was not confirmed in patients aged 19 and older, probably due to a small sample with large variability. In conclusion, these results indicate the importance of nutritional support in cystic fibrosis in all age groups, with the aim of maintaining good lung function as long as possible. It is important to raise awareness of this link among medical staff but also the patients themselves, as they can actively influence their own nutritional status

PHYSICAL PROPERTIES OF PLASTER BANDAGES

Fizikalna svojstva sadrenih zavoja bitan su čimbenik u ostvarenju osnovne funkcije sadrenih imobilizacija (zadržavanje ulomaka kosti u dobrom položaju), a time izravno utječu na brzinu i kvalitetu cijeljenja prijeloma. U ovom radu mjere se fizikalna svojstva (masa, specifična težina, brzina sušenja, krutost i čvrstoća) i bilježe razlike sadrenog ­postupka, brzovežućih sadrenih zavoja širine 10 cm triju različitih proizvođača: Safix plus (Hartmann, Njemačka), Cellona (Lohman Rauscher, Austrija) i Gipsan (Ivo Lola Ribar d. o. o., Hrvatska). Sadreno je deset slojeva zavoja u pločice dimenzija 10 × 10 cm. Od svakog proizvoda načinjene su 24 pločice sadrene u vodi temperature 22 °C i isto toliko u vodi temperature 34 °C. Prosječna specifična težina originalnog pakiranja zavoja bila je: Cellona 0,52 g/cm3, Gipsan 0,50 g/cm3, Safix plus 0,38 g/cm3. Tri dana nakon sadrenja prosječna specifična težina pločica bila je: Gipsan 1,15 g/cm3, Safix plus 1,00 g/cm3, Cellona 1,10 g/cm3. Prosječna vlažnost od 50% pločicâ Safix i Cellona trajala je 18 sati, a pločicâ Gipsan 48 sati nakon sadrenja. Treći dan nakon sadrenja prosječna vlažnost pločica Gipsan bila je 30%, Safixa 24%, a Cellone 16%. Najveću krutost imale su pločice sadrenog zavoja Cellona sadrene vodom temperature 34 °C (11,75 ± 3,18 MPa), a najma­nju (7,21 ± 0,9 MPa) pločice sadrenog zavoja Gipsan sadrene vodom temperature 22 °C. Sadreni zavoj Cellona, sadren vodom temperature 34 °C, pokazuje najveću čvrstoću materijala (4390 ± 838 MPa), a najmanju (771 ± 367 MPa) pločice sadrenog zavoja Gipsan sadrene vodom temperature 22 °C. Sadrenjem zavoja Cellona i Gipsan u toplijoj vodi (34 °C) pločice su bile veće krutosti i čvrstoće. Pločice Safix plus nemaju ovo svojstvo. Sve tri vrste sadrenih zavoja razlikuju se prema fizikalnim svojstvima. S obzirom na masu i specifičnu težinu prije i nakon sadrenja razlike su minimalne. Prema brzini sušenja, čvrstoći i krutosti postoje veće razlike.The physical properties of plaster bandages are a very important factor in achieving the basic functions of ­immobilization (maintaining bone fragments in the best possible position), which directly affects the speed and quality of fracture healing. This paper compares the differences between the physical properties of plaster bandages (mass, specific weight, drying rate, elasticity and strength) and records the differences in plaster modeling of fast bonding 10 cm wide plaster bandages, from three different manufacturers: Safix plus (Hartmann, Germany), Cellona (Lohman Rauscher, Austria) and Gipsan (Ivo Lola Ribar ltd., Croatia). Plaster tiles from ten layers of plaster, dimension 10 x 10 cm were made. The total number of tiles from each manufacturer was 48. The water temperature of 22 °C was used for the first 24 tiles and 34 °C was used for the remainder. The average specific weight of the original packaging was: Cellona (0.52 g/cm3), Gipsan (0.50 g/cm3), Safix plus (0.38 g / cm3). Three days after plaster tile modeling an average specific weight of the tiles was: Gipsan (1.15 g/cm3), Safix plus (1.00 g/cm3), Cellona (1.10 g/cm3). The average humidity of 50% for Safix plus and ­Cellona plaster tiles was recorded 18 hours after modeling, while for the Gipsan plaster tiles, this humidity value was seen after 48 hours. On the third day after plaster modeling the average humidity of the plaster tiles was 30% for Gipsan, 24% for Safix and 16% for Cellona. Cellona plaster tiles made with 34 °C water achieved the highest elasticity (11.75±3.18 MPa), and Gipsan plaster tiles made with 22 °C had the lowest (7.21±0.9 MPa). Cellona plaster tiles made with 34 °C water showed maximum material strength (4390±838 MPa), and Gipsan plaster tiles made with 22 °C water showed the lowest material strength (771±367 MPa). The rigidity and strength of Cellona and Gipsan plaster are higher in tiles made in warmer water, and for Safix plus are higher in tiles made in cooler water. All three types of plaster differentiate in physical properties. The differences in mass and specific weight before and after plaster modeling are minimal. There are greater differences in ­drying rate, elasticity and strength between the three different plaster material

Fizikalna svojstva sadrenih zavoja [Physical properties of plaster bandages]

The physical properties of plaster bandages are a very important factor in achieving the basic functions of immobilization (maintaining bone fragments in the best possible position), which directly affects the speed and quality of fracture healing. This paper compares the differences between the physical properties of plaster bandages (mass, specific weight, drying rate, elasticity and strength) and records the differences in plaster modeling of fast bonding 10 cm wide plaster bandages, from three different manufacturers: Safix plus (Hartmann, Germany), Cellona (Lohman Rauscher, Austria) and Gipsan (Ivo Lola Ribar ltd., Croatia). Plaster tiles from ten layers of plaster, dimension 10 x 10 cm were made. The total number of tiles from each manufacturer was 48. The water temperature of 22 °C was used for the first 24 tiles and 34 'C was used for the remainder. The average specific weight of the original packaging was: Cellona (0.52 g/cm3), Gipsan (0.50 g/cm3), Safix plus (0.38 g/cm3). Three days after plaster tile modeling an average specific weight of the tiles was: Gipsan (1.15 g/cm3), Safix plus (1.00 g/cm3), Cellona (1.10 g/cm3). The average humidity of 50% for Safix plus and Cellona plaster tiles was recorded 18 hours after modeling, while for the Gipsan plaster tiles, this humidity value was seen after 48 hours. On the third day after plaster modeling the average humidity of the plaster tiles was 30% for Gipsan, 24% for Safix and 16% for Cellona. Cellona plaster tiles made with 34 °C water achieved the highest elasticity (11.75±3.18 MPa), and Gipsan plaster tiles made with 22 °C had the lowest (7.21±0.9 MPa). Cellona plaster tiles made with 34 °C water showed maximum material strength (4390±838 MPa), and Gipsan plaster tiles made with 22 °C water showed the lowest material strength (771±367 MPa). The rigidity and strength of Cellona and Gipsan plaster are higher in tiles made in warmer water, and for Safix plus are higher in tiles made in cooler water. All three types of plaster differentiate in physical properties. The differences in mass and specific weight before and after plaster modeling are minimal. There are greater differences in drying rate, elasticity and strength between the three different plaster materials

EXOTHERMIC REACTIONS OF PLASTER IMMOBILIZATION – ANALYSIS OF THREE KINDS OF PLASTER BANDAGES

Egzotermna reakcija sadre iznimno je važno svojstvo koje treba poznavati s obzirom na komplikacije što mogu nastati zbog povišenja temperature u tijeku sadrenja. Razvoj komplikacija izravno utječe na tijek, duljinu i kvalitetu liječenja. U ovom radu bilježe se temperature površine sadrenih pripravaka veličine 10 × 10 cm, brzovežućim sadrenim zavojem širine 10 cm, triju različitih proizvođača: Safix plus (Hartmann, Njemačka), Cellona (Lohmann & Rauscher, Austrija) i Gipsan (Ivo Lola Ribar d. o. o., Hrvatska). Priređene su tri debljine sadrenih pločica (10, 15 i 30 slojeva). Sadrenje je načinjeno u vodi temperature 22 i 34 °C. Unatoč sličnom obrascu ponašanja svih triju sadrenih zavoja izmjerene su razlike. Sve tri vrste sadrenih zavoja koji se rabe u Hrvatskoj u standardnim uvjetima sadrenja imaju nisku razinu egzotermne reakcije, a prosječne su površne temperature niske te nema potencijalne opasnosti od opeklinskih ozljeda. Ako se sadrenje obavljalo u vodi temperature 34 °C, najviše srednje temperature zabilježene su na pločicama (u 15 slojeva) sadrenog zavoja Gipsan (46,2 °C), zatim Cellone (41,3 °C) i Safixa plus (38,9 °C). Pri istoj temperaturi vode sadrenja najviša srednja temperatura izmjerena je na površini pločice (30 slojeva) sadrenog zavoja Gipsan (48,4 °C), zatim Cellone (45,4 °C), a najniža kod pločica sadrenog zavoja Safix plus (41,7 °C). Kada se rabe u debljini od 15 do 30 slojeva, a sadre se vodom temperature 34 °C, sadrene pločice svih proizvođača razvijaju srednje temperature više od 40 °C, u trajanju od 8 do 12 minuta. Od ispitivanih sadrenih zavoja Gipsan (Ivo Lola Ribar d. o. o., Hrvatska) razvijao je najviše temperature, a neke pločice bile su ugrijane na 50 °C. Razine egzotermnih reakcija ispitivanih sadrenih zavoja međusobno se razlikuju prema svim ispitivanim uvjetima, posebice pri sadrenju vodom temperature 34 °C.Exothermic reaction of plaster is a very important characteristic to understand, especially when it comes to complications which can occur during local temperature change during molding plaster of Paris. And these complications directly influence the speed and quality of treatment. In this paper we measured temperatures of plaster bandage tiles 10×10 cm, from three different manufacturers in Croatian hospitals: Safix plus (Hartmann, Germany), Cellona (Lohmann &Rauscher, Austria) and Gipsan ( Ivo Lola Ribar, Croatia). We made three different plaster tiles 10×10 cm, from 10, 15 and 30 layers of plaster bandages. We immersed plaster tiles in two different water temperatures, one group in water 22 °C, and another in 34 °C. Although all plaster bandages have similar chemical characteristics, we have measured some differences. All three kinds of plaster bandages used in Croatia have low exothermic reaction when plaster molding is done in standard conditions, average local temperature is low and there is no danger of local burns. We immersed a plaster tile with 15 layers in water on 34° C, and highest average temperature was measured at Gipsan (46.2 °C), then Cellona (41.3 °C) and Safix plus (38.9 °C). On the same water immersion temperature, on plaster tile with 30 layers average temperatures were Gipsan (48.4°C), Cellona (45.4 °C), and lowest in Safix plus (41.3 °C). Plaster tiles form all manufacturers, when used 15-30 layers thick, and water immersion temperature is 34°C, develop average temperature over 40°C, in duration from 8-12 minutes. Between three different plaster bandages analyzed, Gipsan (Ivo Lola Ribar, Croatia) developed highest temperature, and some plaster tiles were measured over 50 °C

PHYSICAL PROPERTIES OF PLASTER BANDAGES

Fizikalna svojstva sadrenih zavoja bitan su čimbenik u ostvarenju osnovne funkcije sadrenih imobilizacija (zadržavanje ulomaka kosti u dobrom položaju), a time izravno utječu na brzinu i kvalitetu cijeljenja prijeloma. U ovom radu mjere se fizikalna svojstva (masa, specifična težina, brzina sušenja, krutost i čvrstoća) i bilježe razlike sadrenog ­postupka, brzovežućih sadrenih zavoja širine 10 cm triju različitih proizvođača: Safix plus (Hartmann, Njemačka), Cellona (Lohman Rauscher, Austrija) i Gipsan (Ivo Lola Ribar d. o. o., Hrvatska). Sadreno je deset slojeva zavoja u pločice dimenzija 10 × 10 cm. Od svakog proizvoda načinjene su 24 pločice sadrene u vodi temperature 22 °C i isto toliko u vodi temperature 34 °C. Prosječna specifična težina originalnog pakiranja zavoja bila je: Cellona 0,52 g/cm3, Gipsan 0,50 g/cm3, Safix plus 0,38 g/cm3. Tri dana nakon sadrenja prosječna specifična težina pločica bila je: Gipsan 1,15 g/cm3, Safix plus 1,00 g/cm3, Cellona 1,10 g/cm3. Prosječna vlažnost od 50% pločicâ Safix i Cellona trajala je 18 sati, a pločicâ Gipsan 48 sati nakon sadrenja. Treći dan nakon sadrenja prosječna vlažnost pločica Gipsan bila je 30%, Safixa 24%, a Cellone 16%. Najveću krutost imale su pločice sadrenog zavoja Cellona sadrene vodom temperature 34 °C (11,75 ± 3,18 MPa), a najma­nju (7,21 ± 0,9 MPa) pločice sadrenog zavoja Gipsan sadrene vodom temperature 22 °C. Sadreni zavoj Cellona, sadren vodom temperature 34 °C, pokazuje najveću čvrstoću materijala (4390 ± 838 MPa), a najmanju (771 ± 367 MPa) pločice sadrenog zavoja Gipsan sadrene vodom temperature 22 °C. Sadrenjem zavoja Cellona i Gipsan u toplijoj vodi (34 °C) pločice su bile veće krutosti i čvrstoće. Pločice Safix plus nemaju ovo svojstvo. Sve tri vrste sadrenih zavoja razlikuju se prema fizikalnim svojstvima. S obzirom na masu i specifičnu težinu prije i nakon sadrenja razlike su minimalne. Prema brzini sušenja, čvrstoći i krutosti postoje veće razlike.The physical properties of plaster bandages are a very important factor in achieving the basic functions of ­immobilization (maintaining bone fragments in the best possible position), which directly affects the speed and quality of fracture healing. This paper compares the differences between the physical properties of plaster bandages (mass, specific weight, drying rate, elasticity and strength) and records the differences in plaster modeling of fast bonding 10 cm wide plaster bandages, from three different manufacturers: Safix plus (Hartmann, Germany), Cellona (Lohman Rauscher, Austria) and Gipsan (Ivo Lola Ribar ltd., Croatia). Plaster tiles from ten layers of plaster, dimension 10 x 10 cm were made. The total number of tiles from each manufacturer was 48. The water temperature of 22 °C was used for the first 24 tiles and 34 °C was used for the remainder. The average specific weight of the original packaging was: Cellona (0.52 g/cm3), Gipsan (0.50 g/cm3), Safix plus (0.38 g / cm3). Three days after plaster tile modeling an average specific weight of the tiles was: Gipsan (1.15 g/cm3), Safix plus (1.00 g/cm3), Cellona (1.10 g/cm3). The average humidity of 50% for Safix plus and ­Cellona plaster tiles was recorded 18 hours after modeling, while for the Gipsan plaster tiles, this humidity value was seen after 48 hours. On the third day after plaster modeling the average humidity of the plaster tiles was 30% for Gipsan, 24% for Safix and 16% for Cellona. Cellona plaster tiles made with 34 °C water achieved the highest elasticity (11.75±3.18 MPa), and Gipsan plaster tiles made with 22 °C had the lowest (7.21±0.9 MPa). Cellona plaster tiles made with 34 °C water showed maximum material strength (4390±838 MPa), and Gipsan plaster tiles made with 22 °C water showed the lowest material strength (771±367 MPa). The rigidity and strength of Cellona and Gipsan plaster are higher in tiles made in warmer water, and for Safix plus are higher in tiles made in cooler water. All three types of plaster differentiate in physical properties. The differences in mass and specific weight before and after plaster modeling are minimal. There are greater differences in ­drying rate, elasticity and strength between the three different plaster material

Correlation between nutritional status and lung disease in cystic fibrosis

Cistična je fibroza autosomno recesivna nasljedna multisistemna bolest od koje se u Hrvatskoj danas liječi oko 150 bolesnika. Ponajviše pogađa probavni i dišni sustav, stoga su plućna funkcija ( FEV1 - forsirani ekspiratorni volumen u 1 sekundi, % očekivane vrijednosti) i uhranjenost najčešće korišteni parametri za procjenu stanja bolesti. Plućna je funkcija osnovni prediktor smrti te je dugoročno očuvanje plućne funkcije od životne važnosti za oboljele od cistične fibroze. ----- Cilj ove presječne studije bio je dobiti relevantne podatke za oboljele od cistične fibroze u Hrvatskoj te opisati eventualnu povezanost uhranjenosti i plućne funkcije, na što upućuju brojna dosadašnja istraživanja. U istraživanje je uključeno 39 ispitanika starijih od 6 godina (raspon dobi 6 g – 30 g 11 mj.) koji su se tokom 2015. liječili u KBC-u Zagreb. Analizirana je njihova dob, plućna funkcija i prisustvo kronične kolonizacije dišnog puta s Pseudomonasom aeruginosa. Uhranjenost ispitanika mlađih od 19 godina (N=28) zadovoljavajuća je uz medijan 46,55 percentila BMFA (eng. body mass index for age, indeks tjelesne mase za dob). U skupini bolesnika starijih od 19 godina medijan ITM (indeks tjelesne mase) iznosi 21. Plućna funkcija u cijelom promatranom uzorku značajno pada s dobi (snažna negativna korelacija FEV1 % očekivane vrijednosti i dobi, Spearman r=- 0,713, p<0,0001). Također je utvrđena statistički značajno lošija plućna funkcija (Mann-Whitney p=0,0019) u skupini bolesnika kronično koloniziranih s Pseudomonasom aeruginosa (N= 18, prosječan FEV1 61%) u odnosu na nekolonizirane (N = 21, prosječan FEV1 91,6%). U skupini bolesnika mlađih od 19 godina postoji i statistički značajna pozitivna korelacija uhranjenosti i plućne funkcije (Spearman r=0,409, p=0,031), što se nije potvrdilo u bolesnika starijih od 19 g, vjerojatno zbog malog uzorka velike varijabilnosti. ----- Zaključno, rezultati ukazuju na važnost nutricionističke potpore u cističnoj fibrozi u svim dobnim skupinama, a sa ciljem što duljeg održanja dobre plućne funkcije. Važno je o ovoj povezanosti osvijestiti medicinsko osoblje, ali i bolesnike same s obzirom da mogu aktivno utjecati na vlastitu uhranjenost.Cystic fibrosis is an autosomal recessive inherited multisystem disease recognized in about 150 patients today in Croatia. It mainly affects the digestive and respiratory system, so the pulmonary function (FEV1 - forced expiratory volume in 1 second, % predicted) and nutritional status are the most commonly used parameters to assess the state of the disease. Pulmonary function is a primary predictor of mortality and long - term preservation of lung function is of vital importance for patients with cystic fibrosis. ----- The aim of this cross-sectional study was to obtain relevant information for patients with cystic fibrosis in Croatia and describe a possible connection between nutritional status and lung function, as indicated in numerous previous studies. This study included 39 patients aged 6 years and older (age range 6 g - 30 years 11 months) who were treated at the University Hospital Center Zagreb in 2015. Age, pulmonary function and the presence of chronic Pseudomonas aeruginosa colonization in the airways were analyzed. Nutritional status of patients under the age of 19 (N = 28) is satisfactory with median BMFA (body mass index for age) of 46.55 percentile. In patients aged 19 years and older, the median BMI (body mass index) is 21. In the whole study group pulmonary function significantly decreases with age (strong negative correlation between FEV1 % predicted and age, Spearman r = - 0.713, p <0.0001). Statistically significant (Mann-Whitney p = 0.0019) worse lung function was found in patients chronically colonized with Pseudomonas aeruginosa (n = 18, mean FEV1 61%) when compared to those who were not colonized (N = 21, mean FEV1 91.6 %). In the group of patients under the age of 19 there is a statistically significant positive correlation between nutritional status and lung function (Spearman r = 0.409, p = 0.031), which was not confirmed in patients aged 19 and older, probably due to a small sample with large variability. In conclusion, these results indicate the importance of nutritional support in cystic fibrosis in all age groups, with the aim of maintaining good lung function as long as possible. It is important to raise awareness of this link among medical staff but also the patients themselves, as they can actively influence their own nutritional status