Investigating Test Purpose Pluralism and Test Retrofitting in High-Stakes Language Proficiency Testing

There is a lack of clarity in current language testing practices regarding test retrofitting and repurposing. While Newton (2017) advocates for the inclusion of multiple perspectives in new test design, many existing tests are used in cases that extend far beyond their original intent. This literature review examines how despite the availability of 3 different models, there is little publically available research describing test retrofits. It provides an overview of the 3 models, a brief discussion of the available research, including the use of the International English Language Testing System (IELTS) for high-stakes immigration decisions, and concludes with suggestions for future research

English-Language Proficiency Requirements for Migration to Canada, Australia, the United Kingdom, and the United States, and the Implications for Language Testing Research

Language proficiency testing has long played a role as both facilitator and barrier in global migration. This paper outlines how Canada and other traditional migrant destination countries use English-language proficiency testing for immigration, asylum and resettlement, and citizenship. It identifies commonalities between these three related areas of migration and the covert values that are often embedded in the required test scores. It identifies different approaches for conducting research under the umbrella of Shohamy’s (2001) Critical Language Testing and concludes with language testing research and advocacy suggestions specific to the Canadian context.Les tests de compétences linguistiques ont depuis longtemps joué un double rôle au sein de la migration mondiale en étant à la fois un facteur facilitant et un obstacle. Cet article examine comment le Canada et d'autres pays traditionnels d'accueil migratoire emploient les tests de compétences linguistiques en anglais dans les processus d'immigration, les demandes d'asile et de relocalisation, ainsi que les demandes de citoyenneté. Il identifie les points communs entre ces trois domaines connexes de la migration et les valeurs cachées qui sont souvent intégrées dans les résultats des tests exigés. L'article détermine différentes approches pour mener des recherches sous l'égide de l'ouvrage Critical Language Testing de Shohamy (2001) et se conclut avec des suggestions de recherche et de défense des droits en matière de tests linguistiques spécifiques au contexte canadien

Sound of Terror: Hearing Ghosts in Victorian Fiction

Sounds of Terror explores the interrelations between discourses of sound and the ghostly in Victorian novels and short stories. Narrative techniques used by Charles, Dickens, George Eliot, Henry James, and Charlotte Mew are historically and culturally situated through their use of or reactions against acoustic technology. Since ghost stories and nvoels with gothic elements rely for the terrifying effects on tropes of liminality, my study consists of an analysis of an important yet largely unacknowledged species of these tropes: auditory metaphors. Many critics have examined the visual metaphors that appear in nineteenth-century fiction, but, until recently, aural representations have remain critically ignored. The aural itself represents the liminal or the numinous since sounds are less identifiable than visuals because of their ephemeral nature. My study shows the the significance of auditory symbols becomes increasingly intensified as the century progresses. Through analyses of Charles Dickens\u27s David Copperfield, George Eliot\u27s Daniel Deronda, and short stories by Henry James ( The Altar of the Dead and In the Cage )and Charlotte Mew ( Passed and A White Night ), I argue that Victorian writers using gothic modes employ metaphors and symbolism as an alternative to frightening visual images--what could be heard or not heard proved terrifying and dreadful

The MLIIA: Bad Medicine and Bad Law Is a Costly Combination for Texas Minors with Medical Death Claims

This comment explains how the derivative nature of death claims, combined with the MLIIA\u27s accrual dates and its minority tolling provision, result in premature termination of minors\u27 rights to file wrongful death claims caused by medical malpractice. Section I of this comment provides a brief explanation of events prompting the Texas Legislature to enact the MLIIA and the provisions legislators included in the statute to alleviate the perceived health care liability crisis. Section II discusses wrongful death causes of action and compares death causes of action brought under the Wrongful Death Act with death causes of action brought under the MLIIA. Section II also reviews Texas Supreme Court decisions applying the MLIIA to wrongful death claims. Section III surveys federal and state case law holding specific provisions or applications of the MLIIA are unconstitutional. Section IV reviews Texas case law interpreting and applying the MLIIA minority tolling provision to medical wrongful death claims brought by minor beneficiaries and by adult beneficiaries when minors are the decedents. In Section V, the author urges the Texas Legislature to amend the MLIIA minority tolling provision so that limitations commence on all minors\u27 claims at age eighteen. Alternatively, the author urges the Texas Supreme Court to hold the current MLIIA minority tolling provision is unconstitutional, as applied to minors asserting medical wrongful death claims, because it violates the equal protection clause of the Texas Constitution

Limited sex-biased neural gene expression patterns across strains in zebrafish (Danio rerio)

Background: Male and female vertebrates typically differ in a range of characteristics, from morphology to physiology to behavior, which are influenced by factors such as the social environment and the internal hormonal and genetic milieu. However, sex differences in gene expression profiles in the brains of vertebrates are only beginning to be understood. Fishes provide a unique complement to studies of sex differences in mammals and birds given that fish show extreme plasticity and lability of sexually dimorphic characters and behaviors during development and even adulthood. Hence, teleost models can give additional insight into sexual differentiation. The goal of this study is to identify neurotranscriptomic mechanisms for sex differences in the brain. Results: In this study we examined whole-brain sex-biased gene expression through RNA-sequencing across four strains of zebrafish. We subsequently conducted systems level analyses by examining gene network dynamics between the sexes using weighted gene coexpression network analysis. Surprisingly, only 61 genes (approximately 0.4% of genes analyzed) showed a significant sex effect across all four strains, and 48 of these differences were male-biased. Several of these genes are associated with steroid hormone biosynthesis. Despite sex differences in a display of stress-related behaviors, basal transcript levels did not predict the intensity of the behavioral display. WGCNA revealed only one module that was significantly associated with sex. Intriguingly, comparing intermodule dynamics between the sexes revealed only moderate preservation. Further we identify sex-specific gene modules. Conclusions: Despite differences in morphology, physiology, and behavior, there is limited sex-biased neural gene expression in zebrafish. Further, genes found to be sex-biased are associated with hormone biosynthesis, suggesting that sex steroid hormones may be key contributors to sexual behavioral plasticity seen in teleosts. A possible mechanism is through regulating specific brain gene networks

Melissa W. Nash Correspondence

Entries include a typed letter on personal stationery with advice on how to locate the biographical information of Newton and his fellow authors within the pages of his book

Protective Effect of Maritime Quarantine in South Pacific Jurisdictions, 1918–19 Influenza Pandemic

We reviewed mortality data of the 1918–19 influenza pandemic for 11 South Pacific Island jurisdictions. Four of these appear to have successfully delayed or excluded the arrival of pandemic influenza by imposing strict maritime quarantine. They also experienced lower excess death rates than the other jurisdictions that did not apply quarantine measures

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.

PurposeImmune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results of the (nonpancreatic) neuroendocrine neoplasm cohort of SWOG S1609 dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART).Patients and methodsWe performed a prospective, open-label, multicenter phase II clinical trial of ipilimumab plus nivolumab across multiple rare tumor cohorts, with the (nonpancreatic) neuroendocrine cohort reported here. Response assessment by grade was not prespecified. The primary endpoint was overall response rate [ORR; RECIST v1.1; complete response (CR) and partial response (PR)]; secondary endpoints included progression-free survival (PFS), overall survival (OS), stable disease >6 months, and toxicity.ResultsThirty-two eligible patients received therapy; 18 (56%) had high-grade disease. Most common primary sites were gastrointestinal (47%; N = 15) and lung (19%; N = 6). The overall ORR was 25% [95% confidence interval (CI) 13-64%; CR, 3%, N = 1; PR, 22%, N = 7]. Patients with high-grade neuroendocrine carcinoma had an ORR of 44% (8/18 patients) versus 0% in low/intermediate grade tumors (0/14 patients; P = 0.004). The 6-month PFS was 31% (95% CI, 19%-52%); median OS was 11 months (95% CI, 6-∞). The most common toxicities were hypothyroidism (31%), fatigue (28%), and nausea (28%), with alanine aminotransferase elevation (9%) as the most common grade 3/4 immune-related adverse event, and no grade 5 events.ConclusionsIpilimumab plus nivolumab demonstrated a 44% ORR in patients with nonpancreatic high-grade neuroendocrine carcinoma, with 0% ORR in low/intermediate grade disease

Cognitive behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT

Background: Clozapine (clozaril, Mylan Products Ltd) is a first-choice treatment for people with schizophrenia who have a poor response to standard antipsychotic medication. However, a significant number of patients who trial clozapine have an inadequate response and experience persistent symptoms, called clozapine-resistant schizophrenia (CRS). There is little evidence regarding the clinical effectiveness of pharmacological or psychological interventions for this population. Objectives: To evaluate the clinical effectiveness and cost-effectiveness of cognitive–behavioural therapy (CBT) for people with CRS and to identify factors predicting outcome. Design: The Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial was a parallel-group, randomised, outcome-blinded evaluation trial. Randomisation was undertaken using permuted blocks of random size via a web-based platform. Data were analysed on an intention-to-treat (ITT) basis, using random-effects regression adjusted for site, age, sex and baseline symptoms. Cost-effectiveness analyses were carried out to determine whether or not CBT was associated with a greater number of quality-adjusted life-years (QALYs) and higher costs than treatment as usual (TAU). Setting: Secondary care mental health services in five cities in the UK. Participants: People with CRS aged up to 16 years, with an International Classification of Diseases, Tenth Revision (ICD-10) schizophrenia spectrum diagnoses and who are experiencing psychotic symptoms. Interventions: Individual CBT included up to 30 hours of therapy delivered over 9 months. The comparator was TAU, which included care co-ordination from secondary care mental health services. Main outcome measures: The primary outcome was the Positive and Negative Syndrome Scale (PANSS) total score at 21 months and the primary secondary outcome was PANSS total score at the end of treatment (9 months post randomisation). The health benefit measure for the economic evaluation was the QALY, estimated from the EuroQol-5 Dimensions, five-level version (EQ-5D-5L), health status measure. Service use was measured to estimate costs. Results: Participants were allocated to CBT (n = 242) or TAU (n = 245). There was no significant difference between groups on the prespecified primary outcome [PANSS total score at 21 months was 0.89 points lower in the CBT arm than in the TAU arm, 95% confidence interval (CI) –3.32 to 1.55 points; p = 0.475], although PANSS total score at the end of treatment (9 months) was significantly lower in the CBT arm (–2.40 points, 95% CI –4.79 to –0.02 points; p = 0.049). CBT was associated with a net cost of £5378 (95% CI –£13,010 to £23,766) and a net QALY gain of 0.052 (95% CI 0.003 to 0.103 QALYs) compared with TAU. The cost-effectiveness acceptability analysis indicated a low likelihood that CBT was cost-effective, in the primary and sensitivity analyses (probability < 50%). In the CBT arm, 107 participants reported at least one adverse event (AE), whereas 104 participants in the TAU arm reported at least one AE (odds ratio 1.09, 95% CI 0.81 to 1.46; p = 0.58). Conclusions: Cognitive–behavioural therapy for CRS was not superior to TAU on the primary outcome of total PANSS symptoms at 21 months, but was superior on total PANSS symptoms at 9 months (end of treatment). CBT was not found to be cost-effective in comparison with TAU. There was no suggestion that the addition of CBT to TAU caused adverse effects. Future work could investigate whether or not specific therapeutic techniques of CBT have value for some CRS individuals, how to identify those who may benefit and how to ensure that effects on symptoms can be sustained. Trial registration: Current Controlled Trials ISRCTN99672552

Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7 ± 3 years) performed unilateral lower-body training for 6 weeks (3× weekly), where single legs were randomly assigned to HV and HL paradigms. Vastus lateralis (VL) biopsies were obtained prior to study initiation (PRE) as well as 3 days (POST) and 10 days following the last training bout (POSTPR). Body composition and strength tests were performed at each testing session, and biochemical assays were performed on muscle tissue after study completion. Two-way within-subject repeated measures ANOVAs were performed on most dependent variables, and tracer data were compared using dependent samples t-tests. A significant interaction existed for VL muscle cross-sectional area (assessed via magnetic resonance imaging; interaction p = 0.046), where HV increased this metric from PRE to POST (+3.2%, p = 0.018) whereas HL training did not (−0.1%, p = 0.475). Additionally, HL increased leg extensor strength more so than HV training (interaction p = 0.032; HV \u3c HL at POST and POSTPR, p \u3c 0.025 for each). Six-week integrated non-myofibrillar protein synthesis (iNon-MyoPS) rates were also higher in the HV versus HL condition, while no difference between conditions existed for iMyoPS rates. No interactions existed for other strength, VL morphology variables, or the relative abundances of major muscle proteins. Compared to HL training, 6 weeks of HV training in previously trained men optimizes VL hypertrophy in lieu of enhanced iNon-MyoPS rates, and this warrants future research