Drug-induced disseminated intravascular coagulation: a pharmacovigilance study on World Health Organization’s database

Background: Disseminated intravascular coagulation (DIC) occurs in several clinical conditions, including drug therapy. We aim to investigate the association between the administration of several drug classes and the onset of DIC by using the reports of Adverse Drug Reactions (ADR) collected in Vigibase, the World Health Organization (WHO) database of ADR. Methods: We collected reports of drug-related DIC from 1968 to September 2015, classified in Vigibase according to the MedDRA (Medical Dictionary for Regulatory Activities) term “Disseminated intravascular coagulation”. A disproportionality analysis using Reporting Odds Ratio (ROR) with 95% Confidence Interval (CI95%) was performed. Results: Overall, 4653 reports of drug-associated DIC were retrieved and the 75.9% of them was serious according to WHO seriousness criteria. DIC was significantly (ROR > 1, lower limit of CI95% > 1) associated with 88 drugs, mainly antineoplastic agents, antithrombotic agents and antibacterials for systemic use. Among of the most frequently reported individual drugs we found dabigatran (94 reports) ROR = 1.34 (CI95% 1.08–1.67), oxaliplatin and bevacizumab both with 75 reports and ROR = 1.77 (1.38–2.27) and 2.02 (1.57–2.61), respectively. Conclusion: A substantial number of drugs, widely used in the clinical practice, may be associated with the potential occurrence of DIC. For many of these drugs, the ADR is not acknowledged in the corresponding Summary of Product Characteristics. The high number of drugs involved underlines the importance of evaluate this condition such as an ADR that might occur during drug therapy

Masses and decay constants of Bc(∗)B_c^{(*)} mesons with Nf=2+1+1N_f=2+1+1 twisted mass fermions

We present a preliminary lattice determination of the masses and decay constants of the pseudoscalar and vector mesons $B_c$ and $B_c^*$. Our analysis is based on the gauge configurations produced by the European Twisted Mass Collaboration with $N_f = 2 + 1 + 1$ flavors of dynamical quarks. We simulated at three different values of the lattice spacing and with pion masses as small as 210 MeV. Heavy-quark masses are simulated directly on the lattice up to $\sim 3$ times the physical charm mass. The physical b-quark mass is reached using the ETMC ratio method. Our preliminary results are: $M_{B_c} = 6341\,(60)$ MeV, $f_{B_c} = 396\,(12)$ MeV, $M_{B_c^*} / M_{B_c} = 1.0037\,(39)$ and $f_{B_c^*} / f_{B_c} = 0.987\,(7)$.Comment: 7 pages, 3 figures, 1 table; contribution to the proceedings of the XXXVI Int'l Workshop on Lattice Field Theory (LATTICE2018), July 22-28, 2018, East Lansing, Michigan State University (Michigan, USA