The moral terrains of ecotourism and the ethics of consumption

In this chapter, we provide a brief overview of Western philosophical ethics as they may peliain to tourism. Our discussion then turns to one of the most popular attempts to address sustainability across the globe: ecotourism. Ecotourism as distinct from tourism writ large is earmarked by appeals to concepts and ethical practices peliaining to sustainability (in all its varied meanings), consumption, preservation, and the politics of colonialism and the dynamics of global development strategies. In order to bring the ethics of consumption into the context of ecotourism, we provide a case account of ecotourism that represents one of the more popular versions, national park tourism, and the exchanges that occur over what we call the \u27moral terrains\u27 of ecotourism. At Uluru-Kata Tju!a National Park ecotourism pertains to market dynamics, colonialism, adjacent and conflicting heritage, challenges to environmental identity, micro-management strategies aimed at cultural reconciliation and political agency, as well as the cthics of entertainment that plagues tourism as a human form of consumption. We conclude with sections addressing the elevation of the ethics of ecotourism to a quandary of global environmental justice and utilize the controversy of the Uluru-climb to exemplify nOlmative demands on today\u27s quest for sustainable tourism

<i>TP53</i> Gene Status Affects Survival in Advanced Mycosis Fungoides

TP53 is frequently mutated in different types of neoplasms including leukemia and lymphomas. Mutations of TP53 have also been reported in mycosis fungoides (MF), the most common type of cutaneous lymphoma. However, little is known about the frequency, spectrum of mutations and their prognostic significance in MF. In this study we have optimized the protocol for Sanger sequencing of TP53 using DNA extracted from archival paraffin-embedded biopsies. Of 19 samples from patients with stage IIB MF or higher, 31% harboured mutations in TP53. Overall survival of the patients with mutated TP53 was significantly shorter than median survival in the age- and stage-matched patients treated in our Institution. Distribution of mutations was heterogenous in TP53 exons, however C>T transitions were common suggesting the causal role of ultraviolet radiation. We propose that TP53 mutation status would be useful for risk stratification of patients with advanced MF

SCARLET: Source separation in multi-band images by Constrained Matrix Factorization

We present the source separation framework SCARLET for multi-band images, which is based on a generalization of the Non-negative Matrix Factorization to alternative and several simultaneous constraints. Our approach describes the observed scene as a mixture of components with compact spatial support and uniform spectra over their support. We present the algorithm to perform the matrix factorization and introduce constraints that are useful for optical images of stars and distinct stellar populations in galaxies, in particular symmetry and monotonicity with respect to the source peak position. We also derive the treatment of correlated noise and convolutions with band-dependent point spread functions, rendering our approach applicable to coadded images observed under variable seeing conditions. SCARLET thus yields a PSF-matched photometry measurement with an optimally chosen weight function given by the mean morphology in all available bands. We demonstrate the performance of SCARLET for deblending crowded extragalactic scenes and on an AGN jet -- host galaxy separation problem in deep 5-band imaging from the Hyper Suprime-Cam Stategic Survey Program. Using simulations with prominent crowding we show that SCARLET yields superior results to the HSC-SDSS deblender for the recovery of total fluxes, colors, and morphologies. Due to its non-parametric nature, a conceptual limitation of SCARLET is its sensitivity to undetected sources or multiple stellar population within detected sources, but an iterative strategy that adds components at the location of significant residuals appears promising. The code is implemented in Python with C++ extensions and is available at https://github.com/fred3m/scarletComment: accepted by Astronomy & Computin

Impact of Coronary Anatomy and Stenting Technique on Long-Term Outcome After Drug-Eluting Stent Implantation for Unprotected Left Main Coronary Artery Disease

ObjectivesThis study sought to evaluate the impact of anatomic and procedural variables on the outcome of the unprotected left main coronary artery (uLMCA) itself after drug-eluting stent (DES) implantation.BackgroundThere is a controversial debate regarding when and how to perform percutaneous coronary intervention (PCI) for an uLMCA stenosis.MethodsThis analysis is based on a randomized study of 607 patients undergoing PCI for uLMCA, randomized 1:1 to receive paclitaxel- or sirolimus-eluting stents. We evaluated the impact of the SYNTAX score, uLMCA anatomy, and stenting technique on in-stent restenosis (ISR), target lesion revascularization (TLR), and the 3-year outcomes.ResultsThe 3-year cardiac mortality rate was 5.8%; 235 (39%) patients had a true bifurcation lesion (TBL), and the median SYNTAX score was 27. TBL was associated with a higher need for multiple stents (72% vs. 37%, p < 0.001). TBL was a significant predictor of ISR (23% vs. 14%, p = 0.008) and for TLR (18% vs. 9%, p < 0.001). The need for multiple stents was a predictor of ISR (22% vs. 13%, p = 0.005) and for TLR (16% vs. 9%, p = 0.005). Culotte stenting showed better results compared with T-stenting for ISR (21% vs. 56%, p = 0.02) and for TLR (15% vs. 56%, p < 0.001). We observed a significant association between uLMCA-TLR and SYNTAX scores (9.2% for scores ≤22, 14.9% for scores 23 to 32, and 13.0% for scores ≥33, p = 0.008).ConclusionsPCI of uLMCA lesions with DES is safe and effective out to 3 years. TBL and multiple stents were independent predictors for ISR. In the multivariate analysis, independent predictors for TLR were TBL, age, and EuroSCORE (European System for Cardiac Operative Risk Evaluation). (Drug-Eluting-Stents for Unprotected Left Main Stem Disease [ISAR-LEFT-MAIN]; NCT00133237

Effects of administration of a growth promoting implant during the suckling phase or at weaning on growth, reproduction, and ovarian development in replacement heifers grazing native range

Management strategies utilized during pre-breeding development of replacement heifers can impact fertility and the ovarian reserve. Angus- Hereford crossbred heifers (n = 233) were utilized over a 3-yr period to determine the effects of administration of a growth promoting implant at either branding or weaning on growth, reproduction, and ovarian development. Heifer calves were randomly assigned to one of three treatments: 1) nonimplanted controls (CON; n = 79), 2) implanted at approximately 2 mo of age (average calf age = 58 d) with Synovex-C (BIMP, n = 82), or 3) implanted at approximately 7 mo of age (average calf age = 210 d) with Synovex-C (WIMP; n = 72). In years 2 and 3, a subset of heifers (year 2 n = 16; year 3 n = 14) were unilaterally ovariectomized. Heifers implanted at 2 mo of age were heavier at weaning, yearling (mid-February; average calf age = 332 d), and at the beginning of the breeding season (P \u3c 0.01) compared to CON and WIMP heifers. Average daily gain (ADG) was similar among treatments from weaning to yearling and weaning to the start of the breeding season (P ≥ 0.61); however, WIMP heifers had increased (P = 0.05) ADG from yearling to the start of the breeding season compared to BIMP heifers. Antral follicle count and reproductive tract scores were not influenced by implant treatment (P ≥ 0.18). Response to synchronization of estrus was increased (P = 0.02) in WIMP compared to CON heifers, with BIMP heifers similar to all other treatments. First service conception rates tended to be increased (P = 0.09) in CON heifers compared to WIMP heifers, with BIMP heifers similar to CON and WIMP. Final pregnancy rates were similar (P = 0.54) among treatments. A treatment × yr interaction was detected (P = 0.01) for the number of primordial follicles/section with increased primordial follicles in WIMP heifers in year 3 compared to BIMP and WIMP heifers in year 2 and CON heifers in year 3, as well as in BIMP compared to WIMP heifers in year 2. Utilization of growth promoting implants did not negatively impact postweaning reproductive development or compromise pregnancy rates in beef heifers. Based on these results, administration of a growth promoting Synovex-C implant at 2 mo of age may allow for increased body weight at weaning, without hindering reproductive performance