1,023 research outputs found

    The effect of linguistic and visual salience in visual world studies

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    Research using the visual world paradigm has demonstrated that visual input has a rapid effect on language interpretation tasks such as reference resolution and, conversely, that linguistic material-including verbs, prepositions and adjectives-can influence fixations to potential referents. More recent research has started to explore how this effect of linguistic input on fixations is mediated by properties of the visual stimulus, in particular by visual salience. In the present study we further explored the role of salience in the visual world paradigm manipulating language-driven salience and visual salience. Specifically, we tested how linguistic salience (i.e., the greater accessibility of linguistically introduced entities) and visual salience (bottom-up attention grabbing visual aspects) interact. We recorded participants' eye-movements during a MapTask, asking them to look from landmark to landmark displayed upon a map while hearing direction-giving instructions. The landmarks were of comparable size and color, except in the Visual Salience condition, in which one landmark had been made more visually salient. In the Linguistic Salience conditions, the instructions included references to an object not on the map. Response times and fixations were recorded. Visual Salience influenced the time course of fixations at both the beginning and the end of the trial but did not show a significant effect on response times. Linguistic Salience reduced response times and increased fixations to landmarks when they were associated to a Linguistic Salient entity not present itself on the map. When the target landmark was both visually and linguistically salient, it was fixated longer, but fixations were quicker when the target item was linguistically salient only. Our results suggest that the two types of salience work in parallel and that linguistic salience affects fixations even when the entity is not visually present. © 2014 Cavicchio, Melcher and Poesio

    The Construction of a Partially Regular Solution to the Landau-Lifshitz-Gilbert Equation in R2\mathbb{R}^2

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    We establish a framework to construct a global solution in the space of finite energy to a general form of the Landau-Lifshitz-Gilbert equation in R2\mathbb{R}^2. Our characterization yields a partially regular solution, smooth away from a 2-dimensional locally finite Hausdorff measure set. This construction relies on approximation by discretization, using the special geometry to express an equivalent system whose highest order terms are linear and the translation of the machinery of linear estimates on the fundamental solution from the continuous setting into the discrete setting. This method is quite general and accommodates more general geometries involving targets that are compact smooth hypersurfaces.Comment: 43 pages, 2 figure

    Advances in Non-Contact Thermal-Wave Imaging with Infrared Detection

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    We are making further advances in non-destructive and non-contact thermal imaging with infrared detection. We employ a chopped and scanned electron beam as heat source, a cooled HgCdTe infrared detector as temperature sensor, and digital processing of the measured temperature pattern for display and storage. The results give a convincing, high contrast image of subsurface structures

    Plasma Magnetohydrodynamics and Energy Conversion

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    Contains reports on four research projects.National Science Foundation (Grant G-24073)United States Air Force, Aeronautical Systems Division, Aeronautical Accessories Laboratory, Wright-Patterson Air Force Base (Contract AF33(616)-7624

    Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma

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    A fully intact immune system would be expected to hinder the efficacy of oncolytic virotherapy by inhibiting viral replication. Simultaneously, however, it may also enhance antitumor therapy through initiation of proinflammatory, antiviral cytokine responses at the tumor site. The aim of this study was to investigate the role of a fully intact immune system on the antitumor efficacy of an oncolytic virus. In this respect, injection of oncolytic vesicular stomatitis virus (VSV) into subcutaneous B16ova melanomas in C57Bl/6 mice leads to tumor regression, but it is not associated with viral replicative burst in the tumor. In contrast, intratumoral delivery of VSV induces an acute proinflammatory reaction, which quickly resolves concomitantly with virus clearance. Consistent with the hypothesis that therapy may not be dependent on the ability of VSV to undergo progressive rounds of replication, a single-cycle VSV is equally effective as a fully replication-competent VSV, whereas inactivated viruses do not generate therapy. Even though therapy is dependent on host CD8+ and natural killer cells, these effects are not associated with interferon-γ-dependent responses against either the virus or tumor. There is, however, a strong correlation between viral gene expression, induction of proinflammatory reaction in the tumor and in vivo therapy. Overall, our results suggest that acute innate antiviral immune response, which rapidly clears VSV from B16ova tumors, is associated with the therapy observed in this model. Therefore, the antiviral immune response to an oncolytic virus mediates an intricate balance between safety, restriction of oncolysis and, potentially, significant immune-mediated antitumor therapy
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