L\'amylose Laryngée À Propos D\'un Cas

L\'amylose localisée est caractérisée par un dépôt de protéines fibrillaires dans un site de l\'organisme sans atteinte systémique. La localisation laryngée est très rare. Ce diagnostic doit être évoqué devant toute lésion d\'allure bénigne du larynx. Les auteurs rapportent un cas d\'amylose laryngée colligé sur une période de 10 ans.Localized amyloidosis is characterized by the deposition of amyloid fibres in a particular site or organ system in the absence of systemic involvement. The laryngeal location of amylosis is rare. The diagnosis must be suspected in front of any tumor of benign speed of the larynx. Authors report a case of laryngeal amyloidosis brought during a period of 10 years. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 16 2006: pp. 30-3

Le Carcinome Mucoépidermoïde De La Parotide : Apropos De 5 Cas

Les tumeurs des glandes salivaires représentent moins de 5% de toutes les tumeurs de la tête et du cou. Parmi eux, le carcinome mucoépidermoïde est la tumeur la plus fréquente. Quarante cinq pour cent des carcinomes mucoépidermoïdes se développent au niveau de la glande parotide. Cette lésion se voit surtout chez l\'adulte vers la 5ème décade. Le diagnostic est confirmé seulement à l\'examen anatomopathologique. Son pronostic est fonction des critères histologiques.Salivary gland tumors account for less than 5% of the head and neck neoplasms. Among them, mucoepidermoid carcinoma is the most common malignant salivary gland tumor. About 45% of mucoepidermoid carcinomas occur in the parotid gland, and appear around the fifth decade of life. A certain diagnostic can be obtained only after post-operative histological examination. Histological examination indicates the patient prognosis. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 16 2006: pp. 39-4

On the Quality of Experience of Content Sharing in Online Education and Online Meetings

The turn of the decade introduced a new era of global pandemics to the world through the appearance of COVID-19, which is still an active crisis at the time of this paper. As a countermeasure, the phenomena of home office and online education became not only widely available, but also mandatory in many countries. However, the performance, reliability and general usability of such real-time activities may be severely affected by unfavorable network conditions. In both contexts, content sharing is now a common practice, and the success of the related use cases may fundamentally depend on it. In this paper, we present our surveys and subjective studies on the Quality of Experience of content sharing in online education and online meetings. A total of 6 surveys and 5 experiments are detailed, addressing topics of student experience, user interface settings, sharing options of lecturers and employees of the private sector, the perceivable effects of network impairments and the related long-term adaptation, the rubber band effect of slide sharing, the overall perceived quality and the separate quality aspects of media loading times, and the preference between visual quality, average frame rate and frame rate uniformity. The findings of the subjective studies do not characterize the use cases of the investigated topics on a general, widely-applicable level, as only a single online platform is involved throughout the experiments. However, their experimental configurations are reinforced by comprehensive surveys and many results indicate statistically significant differences between the selected test conditions

On the quality of experience of content sharing in online education and online meetings

The turn of the decade introduced a new era of global pandemics to the world through the appearance of COVID-19, which is still an active crisis at the time of this paper. As a countermeasure, the phenomena of home office and online education became not only widely available, but also mandatory in many countries. However, the performance, reliability and general usability of such real-time activities may be severely affected by unfavorable network conditions. In both contexts, content sharing is now a common practice, and the success of the related use cases may fundamentally depend on it. In this paper, we present our surveys and subjective studies on the Quality of Experience of content sharing in online education and online meetings. A total of 6 surveys and 5 experiments are detailed, addressing topics of student experience, user interface settings, sharing options of lecturers and employees of the private sector, the perceivable effects of network impairments and the related long-term adaptation, the rubber band effect of slide sharing, the overall perceived quality and the separate quality aspects of media loading times, and the preference between visual quality, average frame rate and frame rate uniformity. The findings of the subjective studies do not characterize the use cases of the investigated topics on a general, widely-applicable level, as only a single online platform is involved throughout the experiments. However, their experimental configurations are reinforced by comprehensive surveys and many results indicate statistically significant differences between the selected test conditions

Targeting SARS-CoV-2 RBD Interface: a Supervised Computational Data-Driven Approach to Identify Potential Modulators

Coronavirus disease 2019 (COVID-19) has spread out as a pandemic threat affecting over 2 million people. The infectious process initiates via binding of SARS-CoV-2 Spike (S) glycoprotein to host angiotensin-converting enzyme 2 (ACE2). The interaction is mediated by the receptor-binding domain (RBD) of S glycoprotein, promoting host receptor recognition and binding to ACE2 peptidase domain (PD), thus representing a promising target for therapeutic intervention. Herein, we present a computational study aimed at identifying small molecules potentially able to target RBD. Although targeting PPI remains a challenge in drug discovery, our investigation highlights that interaction between SARS-CoV-2 RBD and ACE2 PD might be prone to small molecule modulation, due to the hydrophilic nature of the bi-molecular recognition process and the presence of druggable hot spots. The fundamental objective is to identify, and provide to the international scientific community, hit molecules potentially suitable to enter the drug discovery process, preclinical validation and development. © 2020 Wiley-VCH Gmb