In-Vitro Anticoagulant Study of Leaf Extract of Couropita Guianensis

Anticoagulant activity of different extract of cannon ball tree was evaluated in-vitro. Medicinal plant acts as a metabolic bio factory, which can be accessed as therapeutic potential with lesser side effects. The phyto constituents of various medicinal plants can be correlated with pharmacological study. In vitro study was carried out with a vision to setup standards that could be beneficial for detecting authenticity of this medicinal plant. Numerical standards reported in this work could be useful for the compilation of suitable monograph of Couropita guianensis. Various phyto constituents such as alkaloids, tannins, saponnins and glycosides are producing a better opportunity for testing various pharmacological activities. The results obtained from this research revealed that that the plant contains bioactive agents which are connected with anticoagulant activity in plants

FORMULATION AND DEVELOPMENT OF KETOROLAC TROMETHAMINE OPHTHALMIC SOLUTION

An acetic acid derivative ketorolac tromethmine has found its applicability in both gram positive and gram negative bacterial ocular infection and used commonly associated with multiple doses. Ophthalmic medication stored in multiple dose containers is required by the U.S. Food and Drug Administration to contain a preservative so that patients are provided with microbe free medication. Benzalkonium chloride in concentrations from 0.1% to 0.0001% induced dose-dependent growth arrest and conjunctiva epithelial cell death, either delayed or immediately after administration. In such case, a preservative Benzalkonium chloride must be used within reasonable bound. Benzalkonium chloride can provide more help than harm. Hence the present study focusing on to  formulate a formulation for ketorolac tromethmine (0.5%) ophthalmic solution using different concentration of Benzalkonium chloride as preservative. Keywords: Ketorolac tromethamine, Ophthalmic, benzalkonium chloride, conjunctiv

Antiurolithiatic activity of <i>Crataeva magna</i> Lour. bark

28-33Crataeva magna Lour. bark, commonly known as Baruna, belonging to family Capparaceae, has been investigated for its antiurolithiatic activity in two conventional models (in vivo) of Urolithiasis in rats. The two methods chosen were lactose (30%) + ethylene glycol (1%) and ammonium chloride (2%) + ethylene glycol (0.75%) induced urolithiasis, respectively. The ethanol extract (400 mg/kg bw) reduced the elevated levels of serum calcium (3.25 ± 0.30) and urine calcium (2.33 ± 0.18) significantly (P&lt;0.05), employing lactose (30%) + ethylene glycol (1%) induced urolithiasis model. The ethanol extract (400 mg/kg bw) reduced the urine uric acid level significantly employing both models, viz. lactose (30%) + ethylene glycol (1%) (0.82 ± 0.07; P&lt;0.001) and ammonium chloride (2%) + ethylene glycol (0.75%) (0.85 ± 0.12; P&lt;0.001) when compared to toxic group. The ethanol extract (400 mg/kg bw) employing both models resulted in reduced serum creatinine and calcium, urine oxalate and kidney weight significantly with a marked increase in final body weight and urine volume output when compared to toxic group. The results shown by the ethanol extract (400 mg/kg bw) group was compared to standard polyherbal drug (Cystone; 5 ml/kg bw) treated group and thus exhibited potent antiurolithiatic activity

A SYSTEMATIC REVIEW ON OXALIS CORNICULATA LINN. A CROP FIELD WEED WITH PROMISING PHARMACOLOGICAL ACTIVITIES

Various ailments were known to being treated and cured by several herbs either as a main ingredient or being associated with different medical systems. One such clinically significant and endangered crop field weed is Oxalis corniculata Linn. which is generally found in subtropical and tropical regions across the globe. The medicinal significance of this weed is well evidenced in medicinal scriptures such as Ayurveda, Siddha, Unani, and compendiums of India, China, Britain, and America. The present review highlights on some of the crucial phytoconstituents such as flavonoids, tannins, glycosides, and fatty acids isolated from the said plant and their medicinal applications for treating conditions such as inflammation, anxiety, cancer, and diabetes. Further, the review stresses the future scope for therapeutic applications of these specific phytoconstituents of O. corniculata and the need for its research and development

Synthesis, spectral characterization, <i>in silico</i> and <i>in vitro</i> antimicrobial investigations of some Schiff base metal complexes derived fromazo salicylaldehyde analogues

1267-1276A series of aryl / heteroarylazo substituted salicylaldehyde analogues along with the complexes of the composition [M (L)2(H2O) 2].xH2O where L is deprotonated Schiff base ligand 2-[(E)-(4-methoxyphenylimino) methyl]-4-[(E)-(3-nitrophenyl) diazenyl] phenol 5a(Lig) and M = Cu(II), Ni(II) and Co(II) have been synthesized. The solvent effect of all the titled compounds has been studied using different solvents. The structure of synthesized compounds are confirmed by different spectral techniques viz. elemental analysis 1H NMR, UV-Vis, FT-IR, mass spectrometry, XRD and SEM. The 2-hydroxy-5-[(3-nitrophenyl) diazenyl] benzaldehyde 4d shows excellent significant antibacterial activity against a wide range of bacterial strains in comparison to ampicillin. The compound 4d exhibits better antifungal activity than its complexes and intermediate Schiff base against A. niger, T. rubrum and C. glabrata in comparison to fluconazole. The results of in vitro antibacterial activities of the said synthesized compounds also reveals that compound 4c and 4e exhibit the highest zone of inhibition against S. flexneri, which strongly supports the results of in silico investigation