Severe loneliness and isolation in nursing students during Covid-19 lockdown: a phenomenological study

In 2022, COVID-19 continued to spread across the globe, and to stop the spread of the virus and protect people’s health, universities across China continued to remain in a lockdown state. Loneliness is an important topic among college students, and the coronavirus pandemic has exacerbated loneliness. This prolonged school lockdown was unprecedented and it caused severe social isolation and emotional loneliness for students. Few people know how nursing students experience loneliness and find a way through their experience. This qualitative phenomenological study was conducted to reveal the lived experiences of nursing students who indicated COVID-19 lockdown-related loneliness in a previous quantitative survey. We performed 20 semi-structured interviews with nursing students aged 19–23 yrs during their lockdown (April 2022 to June 2022). Our research applied Colaizzi’s seven-step data analysis processes to reveal shared patterns in terms of how nursing students experienced lockdown and found the following four themes: emotional challenges associated with loneliness; causes of loneliness; positive and negative motivation to learn; and accepting solitude and reconstructing real life

Pharmacokinetic Comparison of Ferulic Acid in Normal and Blood Deficiency Rats after Oral Administration of Angelica sinensis, Ligusticum chuanxiong and Their Combination

Radix Angelica Sinensis (RAS) and Rhizome Ligusticum (RLC) combination is a popular herb pair commonly used in clinics for treatment of blood deficiency syndrome in China. The aim of this study is to compare the pharmacokinetic properties of ferulic acid (FA), a main bioactive constituent in both RAS and RLC, between normal and blood deficiency syndrome animals, and to investigate the influence of compatibility of RAS and RLC on the pharmacokinetic of FA. The blood deficiency rats were induced by injecting 2% Acetyl phenylhydrazine (APH) on the first day, every other day, to a total of five times, at the dosage of 100, 50, 50, 30, 30 mg/kg body mass, respectively. Quantification of FA in rat plasma was achieved by using a simple and rapid HPLC method. Plasma samples were collected at different time points to construct pharmacokinetic profiles by plotting drug concentration versus time, and estimate pharmacokinetic parameters. Between normal and blood deficiency model groups, both AUC(0–t) and Cmax of FA in blood deficiency rats after RAS-RLC extract administration increased significantly (P < 0.05), while clearance (CL) decreased significantly. Among three blood deficiency model groups, t1/2α, Vd, AUC(0–t) and AUC(0–∞) all increased significantly in the RAS-RLC extract group compared with the RAS group. The results indicated that FA was absorbed better and eliminated slower in blood deficiency rats; RLC could significantly prolong the half-life of distribution, increase the volume of distribution and the absorption amount of FA of RAS in blood deficiency rats, which may be due to the synergic action when RAS and RLC were used together to treat blood deficiency syndrome

Nirvana: A Qualitative Study of Posttraumatic Growth in Adolescents and Young Adults with Inflammatory Bowel Disease

(1) Background: Psychosomatic discomfort is prevalent among adolescents and young adults (AYAs) with inflammatory bowel disease (IBD). Post-traumatic growth (PTG) has been a protective factor in earlier research. However, little is known regarding PTG among AYAs with IBD. This study investigates the generation of PTG in adolescents and young adults with inflammatory bowel disease (IBD) and finds positive coping skills employed in clinical nursing practice. (2) Methods: In 2021, 32 individuals were interviewed utilizing a semi-structured interview guide. This study used qualitative content analysis. (3) Results: The interviews revealed five themes: spiritual change, internalized supportiveness, cognitive re-shaping, externalized behaviors, and future-oriented thinking. (4) Conclusions: The research revealed the presence of PTG in AYAs with IBD. To give tailored care to patients, medical professionals must monitor the state of their PTG development in a planned and focused manner

Analysis of Plant Height Changes of Lodged Maize Using UAV-LiDAR Data

Lodging stress seriously affects the yield, quality, and mechanical harvesting of maize, and is a major natural disaster causing maize yield reduction. The aim of this study was to obtain light detection and ranging (LiDAR) data of lodged maize using an unmanned aerial vehicle (UAV) equipped with a RIEGL VUX-1UAV sensor to analyze changes in the vertical structure of maize plants with different degrees of lodging, and thus to use plant height to quantitatively study maize lodging. Based on the UAV-LiDAR data, the height of the maize canopy was retrieved using a canopy height model to determine the height of the lodged maize canopy at different times. The profiles were analyzed to assess changes in maize plant height with different degrees of lodging. The differences in plant height growth of maize with different degrees of lodging were evaluated to determine the plant height recovery ability of maize with different degrees of lodging. Furthermore, the correlation between plant heights measured on the ground and LiDAR-estimated plant heights was used to verify the accuracy of plant height estimation. The results show that UAV-LiDAR data can be used to achieve maize canopy height estimation, with plant height estimation accuracy parameters of R2 = 0.964, RMSE = 0.127, and nRMSE = 7.449%. Thus, it can reflect changes of plant height of lodging maize and the recovery ability of plant height of different lodging types. Plant height can be used to quantitatively evaluate the lodging degree of maize. Studies have shown that the use of UAV-LiDAR data can effectively estimate plant heights and confirm the feasibility of LiDAR data in crop lodging monitoring

Characteristics of syphilitic uveitis in northern China

Abstract Background To describe the characteristics of patients with syphilitic uveitis in northern China. Methods A case series of 21 patients (33 eyes) diagnosed with syphilitic uveitis from 2011 to 2016 at a tertiary center in northern China was retrospectively analyzed. Results Twenty-one patients (33 eyes) were diagnosed as syphilitic uveitis. Posterior segment involvement was found in 32 eyes (97.0%). Vitreous haze, neuroretinitis, and posterior placoid chorioretinitis were mainly found in patients with a relatively short duration of the disease, while diffuse chorioretinitis, pseudoretinitis pigmentosa, cystoid macular edema, and epiretinal membrane were found in patients with relatively long duration of ocular involvement. A low best-corrected visual acuity (P = 0.022) and a delay of syphilis treatment (P < 0.001) were associated with a significantly worse visual outcome. Conclusions Syphilitic uveitis should be included in the differential diagnosis of any form of posterior ocular inflammation. The pattern of ocular involvement may change with the disease progression

Monitoring Maize Lodging Grades via Unmanned Aerial Vehicle Multispectral Image

Lodging is one of the main factors affecting the quality and yield of crops. Timely and accurate determination of crop lodging grade is of great significance for the quantitative and objective evaluation of yield losses. The purpose of this study was to analyze the monitoring ability of a multispectral image obtained by an unmanned aerial vehicle (UAV) for determination of the maize lodging grade. A multispectral Parrot Sequoia camera is specially designed for agricultural applications and provides new information that is useful in agricultural decision-making. Indeed, a near-infrared image which cannot be seen with the naked eye can be used to make a highly precise diagnosis of the vegetation condition. The images obtained constitute a highly effective tool for analyzing plant health. Maize samples with different lodging grades were obtained by visual interpretation, and the spectral reflectance, texture feature parameters, and vegetation indices of the training samples were extracted. Different feature transformations were performed, texture features and vegetation indices were combined, and various feature images were classified by maximum likelihood classification (MLC) to extract four lodging grades. Classification accuracy was evaluated using a confusion matrix based on the verification samples, and the features suitable for monitoring the maize lodging grade were screened. The results showed that compared with a multispectral image, the principal components, texture features, and combination of texture features and vegetation indices were improved by varying degrees. The overall accuracy of the combination of texture features and vegetation indices is 86.61%, and the Kappa coefficient is 0.8327, which is higher than that of other features. Therefore, the classification result based on the feature combinations of the UAV multispectral image is useful for monitoring of maize lodging grades

Two Magnetic Orderings and a Spin&ndash;Flop Transition in Mixed Valence Compound Mn3O(SeO3)3

A mixed-valence manganese selenite, Mn3O(SeO3)3, was successfully synthesized using a conventional hydrothermal method. The three-dimensional framework of this compound is composed of an MnO6 octahedra and an SeO3 trigonal pyramid. The magnetic topological arrangement of manganese ions shows a three-dimensional framework formed by the intersection of octa-kagom&eacute; spin sublattices and staircase-kagom&eacute; spin sublattices. Susceptibility, magnetization and heat capacity measurements confirm that Mn3O(SeO3)3 exhibits two successive long-range antiferromagnetic orderings with TN1~4.5 K and TN2~45 K and a field-induced spin&ndash;flop transition at a critical field of 4.5 T at low temperature

Fabrication of cationic cellulose nanofibrils/sodium alginate beads for Congo red removal

Summary: Congo red is hard to remove from dye wastewater due to its structure stability and high chemical oxygen demand. In this study, cationic cellulose nanofibrils (CCNF) prepared from herb residues was physically crosslinked with sodium alginate (SA) in the presence of calcium ions, and the obtained CCNF/SA beads were used to adsorb Congo red. Results showed that CCNF/SA beads with porous internal structure were beneficial to adsorption. The maximum adsorption capacity of Congo red could reach to 518.4 mg/g, which was superior to most cellulose-based adsorption materials. Furthermore, the equilibrium adsorption isotherms and XPS analysis indicated the adsorption for Congo red was a physical process, and hydrogen bond and electrostatic adsorption were proposed as dominant adsorption mechanism. In addition, the Congo red removal efficiency of the beads was still higher than 70% after three cycles. Therefore, this high efficiency and green beads have great potential as adsorbents for anionic dyes removal

SPSL1 is essential for spermatophore formation and sperm activation in Spodoptera frugiperda.

The reproductive process in various species has undergone evolutionary adaptations at both the physiological and molecular levels, playing a significant role in maintaining their populations. In lepidopteran insects, the spermatophore is a unique structure formed in the female reproductive system, in which sperm storage and activation take place. It is known that the formation of the spermatophore is regulated by seminal fluid proteins derived from males. However, studies investigating the genetic mechanisms behind spermatophore formation in lepidopterans have been limited. In this study, our focus was on SPSL1, a gene that encodes a trypsin-type seminal fluid protein in Spodoptera frugiperda, a pest species with global invasive tendencies. Our findings revealed that SPSL1 expression was predominantly observed in the male reproductive tracts, and the disruption of this gene resulted in male sterility. Surprisingly, fluorescence analysis indicated that the absence of SPSL1 did not affect spermatogenesis or sperm migration within the male reproductive system. However, when females mated with SPSL1-mutant males, several defects were observed. These included disruptions in spermatophore formation, sperm activation in the copulatory bursae, and sperm migration into the spermathecae. Additionally, mass spectrometry analysis highlighted reduced levels of energy-related metabolites, suggesting that SPSL1 plays an essential role in promoting hydrolysis reactions during copulation. Consequently, our study demonstrates that SPSL1 is crucial for male fertility due to its functions in spermatophore formation and sperm activation. This research provides valuable insights into the genetic factors underlying reproductive processes in lepidopteran insects and sheds light on potential strategies for controlling invasive pest populations