4,865 research outputs found
Thermal diffusion of supersonic solitons in an anharmonic chain of atoms
We study the non-equilibrium diffusion dynamics of supersonic lattice
solitons in a classical chain of atoms with nearest-neighbor interactions
coupled to a heat bath. As a specific example we choose an interaction with
cubic anharmonicity. The coupling between the system and a thermal bath with a
given temperature is made by adding noise, delta-correlated in time and space,
and damping to the set of discrete equations of motion. Working in the
continuum limit and changing to the sound velocity frame we derive a
Korteweg-de Vries equation with noise and damping. We apply a collective
coordinate approach which yields two stochastic ODEs which are solved
approximately by a perturbation analysis. This finally yields analytical
expressions for the variances of the soliton position and velocity. We perform
Langevin dynamics simulations for the original discrete system which fully
confirm the predictions of our analytical calculations, namely noise-induced
superdiffusive behavior which scales with the temperature and depends strongly
on the initial soliton velocity. A normal diffusion behavior is observed for
very low-energy solitons where the noise-induced phonons also make a
significant contribution to the soliton diffusion.Comment: Submitted to PRE. Changes made: New simulations with a different
method of soliton detection. The results and conclusions are not different
from previous version. New appendixes containing information about the system
energy and soliton profile
Asymptotic adaptive methods for multi-scale problems in fluid mechanics
This paper reports on the results of a three-year research effort aimed at investigating and exploiting the role of physically motivated asymptotic analysis in the design
of numerical methods for singular limit problems in fluid mechanics. Such problems naturally arise, among others, in combustion, magneto-hydrodynamics and geophysical fluid mechanics. Typically, they are characterized by multiple space and/or time scales and by the disturbing fact that standard computational techniques fail entirely, are
unacceptably expensive, or both. The challenge here is to construct numerical methods which are robust, uniformly accurate, and efficient through different asymptotic
regimes and over a wide range of relevant applications.
Summaries of multiple scales asymptotic analyses for low Mach number flows, magnetohydrodynamics at small Mach and Alfv´en numbers, and of multiple scales atmospheric flows are provided. These reveal singular balances between selected terms in the respective governing equations within the considered flow regimes. These singularities give rise to problems of severe stiffness, stability, or to dynamic range issues in straightforward numerical discretizations.
Aformal mathematical framework for the multiple scales asymptotics is then summarized using the example of multiple length scale – single time scale asymptotics for low Mach number flows.
The remainder of the paper focuses on the construction of numerical discretizations for the respective full governing equation systems. These discretizations avoid the pitfalls of singular balances by exploiting the asymptotic results. Importantly, the asymptotics are not used here to derive simplified equation systems, which are then solved numerically. Rather, we aim at numerically integrating the full equation sets and at using the asymptotics only to construct discretizations that do not deteriorate as a singular limit is approached.
One important ingredient of this strategy is the numerical identification of a singular limit regime given a set of discrete numerical state variables. This problem is addressed in an exemplary fashion for multiple length – single time scale low Mach number flows in one space dimension. The strategy allows a dynamic determination
of an instantaneous relevant Mach number, and it can thus be used to drive the appropriate adjustment of the numerical discretizations when the singular limit regime
is approached
Numerical electrokinetics
A new lattice method is presented in order to efficiently solve the
electrokinetic equations, which describe the structure and dynamics of the
charge cloud and the flow field surrounding a single charged colloidal sphere,
or a fixed array of such objects. We focus on calculating the electrophoretic
mobility in the limit of small driving field, and systematically linearise the
equations with respect to the latter. This gives rise to several subproblems,
each of which is solved by a specialised numerical algorithm. For the total
problem we combine these solvers in an iterative procedure. Applying this
method, we study the effect of the screening mechanism (salt screening vs.
counterion screening) on the electrophoretic mobility, and find a weak
non-trivial dependence, as expected from scaling theory. Furthermore, we find
that the orientation of the charge cloud (i. e. its dipole moment) depends on
the value of the colloid charge, as a result of a competition between
electrostatic and hydrodynamic effects.Comment: accepted for publication in Journal of Physics Condensed Matter
(proceedings of the 2012 CODEF conference
Steps in the bacterial flagellar motor
The bacterial flagellar motor is a highly efficient rotary machine used by
many bacteria to propel themselves. It has recently been shown that at low
speeds its rotation proceeds in steps [Sowa et al. (2005) Nature 437,
916--919]. Here we propose a simple physical model that accounts for this
stepping behavior as a random walk in a tilted corrugated potential that
combines torque and contact forces. We argue that the absolute angular position
of the rotor is crucial for understanding step properties, and show this
hypothesis to be consistent with the available data, in particular the
observation that backward steps are smaller on average than forward steps. Our
model also predicts a sublinear torque-speed relationship at low torque, and a
peak in rotor diffusion as a function of torque
Magnetic and electronic Co states in layered cobaltate GdBaCo2O5.5-x
We have performed non-resonant x-ray diffraction, resonant soft and hard
x-ray magnetic diffraction, soft x-ray absorption and x-ray magnetic circular
dichroism measurements to clarify the electronic and magnetic states of the
Co3+ ions in GdBaCo2O5.5. Our data are consistent with a 3+ Py Co HS state at
the pyramidal sites and a 3+ Oc Co LS state at the octahedral sites. The
structural distortion, with a doubling of the a axis (2ap x 2ap x 2ap cell),
shows alternating elongations and contractions of the pyramids and indicates
that the metal-insulator transition is associated with orbital order in the t2g
orbitals of the 3+ Py Co HS state. This distortion corresponds to an
alternating ordering of xz and yz orbitals along the a and c axes for the 3+ Py
Co . The orbital ordering and pyramidal distortion lead to deformation of the
octahedra, but the 3+ Oc Co LS state does not allow an orbital order to occur
for the 3+ Oc Co ions. The soft x-ray magnetic diffraction results indicate
that the magnetic moments are aligned in the ab plane but are not parallel to
the crystallographic a or b axes. The orbital order and the doubling of the
magnetic unit cell along the c axis support a non-collinear magnetic structure.
The x-ray magnetic circular dichroism data indicate that there is a large
orbital magnetic contribution to the total ordered Co moment
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Flexible In-Ga-Zn-O based circuits with two and three metal layers: simulation and fabrication study
The quest for high-performance flexible circuits call for scaling of the minimum feature size in Thin-Film Transistors (TFTs). Although reduced channel lengths can guarantee an improvement in the electrical properties of the devices, proper design rules also play a crucial role to minimize parasitics when designing fast circuits. In this letter, systematic Computer-Aided Design (CAD) simulations have guided the fabrication of highperformance flexible operational amplifiers (opamps) and logic circuits based on Indium-Gallium-Zinc-Oxide (IGZO) TFTs. In particular, the performance improvements due to the use of an additional third metal layer for the interconnections has been estimated for the first time. Encouraged by the simulated enhancements resulting by the decreased parasitic resistances and capacitances, both TFTs and circuits have been realized on a free-standing 50ÎĽm thick polymide foil using three metal layers. Despite the thicker layer stack, the TFTs have shown mechanical stability down to 5mm bending radii. Moreover, the opamps and the logic circuits have yielded improved electrical performance with respect to the architecture with two metal layers: gainbandwidth- product (GBWP) increased by 16:9%, for the first one, and propagation delay (tpd) decreased by 43%, for the latter one
Radio frequency electronics on plastic
In this paper the recent progress of active high frequency electronics on plastic is discussed. This technology is mechanically flexible, bendable, stretchable and does not need any rigid chips. Indium Gallium Zinc Oxide (IGZO) technology is applied. At 2 V supply and gate length of 0.5 ÎĽm, the thin-film transistors (TFTs) yield a measured transit frequency of 138 MHz. Our scalable TFT compact simulation model shows good agreement with measurements. To achieve a sufficiently high yield, TFTs with gate lengths of around 5 ÎĽm are used for the circuit design. A Cherry Hopper amplifier with 3.5 MHz bandwidth, 10 dB gain and 5 mW dc power is presented. The fully integrated receiver covering a plastic foil area of 3 Ă— 9 mm2 includes a four stage cascode amplifier, an amplitude detector, a baseband amplifier and a filter. At a dc current of 7.2 mA and a supply of 5 V, a bandwidth of 2 - 20 MHz and a gain beyond 15 dB were measured. Finally, an outlook regarding future advancements of high frequency electronics on plastic is given
Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved. We undertook a large-scale approach at characterising molecular receptive ranges (MRRs) of glomeruli in the dorsal olfactory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ortholog OR51E2. Guided by an iterative approach that combined biological screening and machine learning, we selected 214 odorants to characterise the response of MOR18-2 and its neighbouring glomeruli. We found that a combination of conventional physico-chemical and vibrational molecular descriptors performed best in predicting glomerular responses using nonlinear Support-Vector Regression. We also discovered several previously unknown odorants activating MOR18-2 glomeruli, and obtained detailed MRRs of MOR18-2 glomeruli and their neighbours. Our results confirm earlier findings that demonstrated tunotopy, that is, glomeruli with similar tuning curves tend to be located in spatial proximity in the dOB. In addition, our results indicate chemotopy, that is, a preference for glomeruli with similar physico-chemical MRR descriptions being located in spatial proximity. Together, these findings suggest the existence of a partial chemical map underlying glomerular arrangement in the dOB. Our methodology that combines machine learning and physiological measurements lights the way towards future high-throughput studies to deorphanise and characterise structure-activity relationships in olfaction.Peer reviewe
ifo Konjunkturprognose 2009: Deutsche Wirtschaft in der Rezession
Am 11. Dezember 2008 stellte das ifo Institut im Rahmen seines vorweihnachtlichen Pressegesprächs seine Prognose für die Jahre 2009 und 2010 vor. Die Weltwirtschaft befindet sich in einem massiven Abschwung. Die schwere Krise an den internationalen Finanzmärkten, die in den USA mit dem Zusammenbruch des Subprime-Hypothekenmarkts 2007 begonnen hatte, hat inzwischen auf alle Wirtschaftsbereiche übergegriffen. Für Unternehmen und private Haushalte haben sich die Finanzierungsbedingungen verschlechtert, zudem dämpfen Vermögensverluste und eingetrübte Ertragsaussichten. Alles in allem deutet diese Datenkonstellation auf eine globale Rezession im Jahr 2009 hin. In Deutschland ist die Konjunktur seit der Jahresmitte 2008 deutlich abwärts gerichtet. Insgesamt sprechen die verfügbaren Konjunkturindikatoren dafür, dass die gesamtwirtschaftliche Produktion saison- und kalenderbereinigt im Jahresendquartal 2008 stark beschleunigt gesunken ist; die laufende Jahresrate dürfte –3½% betragen haben. Zugleich ist der Auslastungsgrad im Verlauf des vierten Quartals unter den langjährigen Durchschnittswert gefallen. Die deutsche Wirtschaft ist damit in der Rezession. Im Jahresdurchschnitt 2008 dürfte das reale Bruttoinlandsprodukt um 1,5% expandiert haben, nach 2,5% im Vorjahr. 2009 wird das reale Bruttoinlandsprodukt dem Ursprungswert nach wie auch kalenderbereinigt um 2,2% abnehmen. Erst im Jahr 2010 ist mit dem allmählichen Abebben der Finanzkrise und der leichten Besserung des internationalen Umfelds eine Stabilisierung zu erwarten. Aufgrund des Unterhangs wird das reale Bruttoinlandsprodukt im Jahresdurchschnitt 2010 jedoch immer noch um 0,2% sinken.Konjunktur, Konjunkturumfrage, Konjunkturprognose, Wirtschaftslage, Geschäftsklima, Deutschland, Welt
Germline genetic variants of the renin-angiotensin system, hypoxia and angiogenesis in non-small cell lung cancer progression: Discovery and validation studies
Introduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Genotyping of 52 germline variants from genes of the RAS and hypoxic/angiogenic factors/receptors was performed using MassARRAY iPLEX Gold in a retrospective cohort (n = 167) of advanced NSCLC patients. Validation of the resulting genetic markers was conducted in an independent group (n = 190), matched by clinicopathological characteristics. Results: Multivariate analysis on the discovery set revealed that MME rs701109 C carriers were protected from disease progression in comparison with homozygous T (hazard ratio (HR) = 0.5, 95% confidence interval (CI) = 0.2–0.8, p = 0.010). Homozygous A and T genotypes for KDR rs1870377 were at increased risk for disease progression and death compared to heterozygous (HR = 1.7, 95% CI = 1.2–2.5, p = 0.005 and HR = 2.1, 95% CI = 1.2–3.4, p = 0.006, respectively). Carriers of homozygous genotypes for ACE2 rs908004 presented increased risk for disease progression, only in the subgroup of patients without tumour actionable driver mutations (HR = 2.9, 95% CI = 1.3–6.3, p = 0.010). Importantly, the association of homozygous genotypes in MME rs701109 with risk for disease progression was confirmed after multivariate analysis in the validation set. Conclusion: This study provides evidence that MME polymorphism, which encodes neprilysin, may modulate progression-free survival in advanced NSCLC. Present genetic variation findings will foster basic, translational, and clinical research on their role in NSCLC.M.J.C. was supported by the Associação de Estudos Respiratórios and the Portuguese Pulmonology Society
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