36 research outputs found
Rivulichthys luelingi nov. spec., eine Zahnkarpfen-Neuheit aus Ostbolivien (Pisces, Teleostei, Rivulinae)
Volume: 20Start Page: 423End Page: 42
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Ruthenium-97 labeled compounds: a new class of radiopharmaceuticals. [Preparation, tissue distribution, and imaging studies]
The excellent physical properties of 2.9 day ruthenium-97 (216 KeV ..gamma.., 86%) combined with its chemical reactivity were exploited for the design of versatile new radiopharmaceuticals. Complexes of ruthenium (III and IV) with citrate, DTPA, MDP, EHDP, PYP, ethylenediaminetetramethylene phosphonate (EDTMP), and oxine 7-carboxylic acid acetate, and of ruthenium (II) with 1,10-phenanthroline and 3,4,7,8-tetramethyl 1,10-phenanthroline were prepared and studied. Preparation of a ruthenium--sulfur colloid was achieved and its application in lymphangiography was demonstrated. Ruthenium chloride clears from the blood slowly; at 24 hr, the activity remains diffused all over the body including muscle, and excretion is only partial. Ru-DTPA and Ru-citrate both are eliminated rapidly via the kidneys. Ru-EHDP and Ru-EDTMP clear fast from the blood and localize in bone. The oxine complex showed excellent promise as a hepatobiliary agent; excretion via the kidneys was negligible. Several complexes of Ru (II) and ammine-Ru (III), especially with nitrogen heterocycles such as pyridines, phenanthrolines, and purine bases are under evaluation in animal tumor models. Uptake of ruthenium phosphate compounds in experimental myocardial infarcts shows promise. BLIP production of Ru-97 has been achieved using the Rh-103 (p, 2p5n) Ru-97 reaction (> 100 mCi/day). These results reinforce our optimism regarding the potential of ruthenium-97 in nuclear medicine, in particular when periodic or delayed scans are either necessary or desirable in order to diagnose or monitor the progress of disease
Zusammenarbeit der Bundesanstalt fuer Arbeit mit externen Forschern auf dem Gebiet der Arbeitsmarktstatistik. Stufe 1 Abschlussbericht
Available from TIB Hannover: F03B238 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman