2,645 research outputs found
Effect of Astragalus membranaceus (Fisch) Bunge extract on streptozocin-induced diabetic in rats
Purpose: To investigate the effect of Astragalus membranaceus (Fisch.) Bunge. extract (AMBE) on streptozotocin-induced diabetic rats.Methods: The aqueous extract of AMB was obtained by steeping the dried Astragalus membranaceus (Fisch.) Bunge. in water at 60 oC three times, each for 1 h, before first drying in an oven at 100 oC and then freeze-drying the last extract thus obtained. Diabete model rats was induced by a single intraperitoneal injection of a freshly prepared solution of streptozotocin (50 mg/kg). The rats were randomly divided into 6 groups of ten rats each: negative control group, normal control group, reference group (glibenclamide1 mg/kgbody weight) as well as AMB extract groups, namely, 40, 80 and 160 mg/kg body weight. Antihyperglycemic effect was measured by blood glucose and plasma insulin levels. Oxidative stress was evaluated in liver and kidney by antioxidant markers, viz, lipidperoxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase (CAT), while blood serum levels of creatinine and urea were also determined in both diabetic control and treated rats.Results: Compared with diabetic rats, oral administration of AMBE at a concentration of 160 mg/kg daily for 30 days showed a significant decrease in fasting blood glucose (109.438 ± 3.52, p < 0.05) and increased insulin level (13.96 ± 0.74, p < 0.05). Furthermore, it significantly reduced biochemical parameters (serum creatinine, 0.86 ± 0.29, p < 0.05) and serum urea (45.14 ± 1.79, p < 0.05). The treatment also resulted in significant increase in GSH (49.21 ± 2.59, p < 0.05), GPx (11.96 ± 1.16, p < 0.05), SOD (14.13 ± 0.49, p < 0.05), CAT (83.25 ± 3.14, p < 0.05) level in the liver and kidney of diabetic rats.Conclusion: The results suggest that AMBE may effectively normalize impaired antioxidant status in streptozotocin-induced diabetes in a dose-dependent manner. AMBE has a protective effect against lipid peroxidation by scavenging free radicals and is thus capable of reducing the risk of diabetic complications.Keywords: Astragalus membranaceus, Diabetic, Antihyperglycemic, Antioxidant Oxidative stress, Fasting blood glucos
(2′-Amino-4,4′-bi-1,3-thiazol-2-aminium-κ2 N,N′)aqua[citrato(4−)-κ3 O,O′,O′′)chromium(III) dihydrate
In the title compound, [Cr(C6H7N4S2)(C6H4O7)(H2O)]·2H2O, the CrIII atom is in a distorted octahedral environment, coordinated by one water molecule, two N atoms from a protonated diaminobithiazole ligand and three O atoms from a citrate(4−) anion. The complex is zwitterionic, with the H atom from the uncoordinated carboxylate group of the citrate anion transferred to one amino group of the diaminobithiazole ligand. O—H⋯O and N—H⋯O hydrogen bonds link the complexes into layers including the two uncoordinated water molecules
Effects of losses in the hybrid atom-light interferometer
Enhanced Raman scattering can be obtained by injecting a seeded light field
which is correlated with the initially prepared collective atomic excitation.
This Raman amplification process can be used to realize atom-light hybrid
interferometer. We numerically calculate the phase sensitivities and the
signal-to-noise ratios of this interferometer with the method of homodyne
detection and intensity detection, and give their differences between this two
methods. In the presence of loss of light field and atomic decoherence the
measure precision will be reduced which can be explained by the break of the
intermode decorrelation conditions of output modesComment: 9 pages, 7 figure
MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells.
Pancreatic adenocarcinoma is one of the most leading causes of cancer-related deaths worldwide. Although recent advances provide various treatment options, pancreatic adenocarcinoma has poor prognosis due to its late diagnosis and ineffective therapeutic multimodality. Gemcitabine is the effective first-line drug in pancreatic adenocarcinoma treatment. However, gemcitabine chemoresistance of pancreatic adenocarcinoma cells has been a major obstacle for limiting its treatment effect. Our study found that p70S6K1 plays an important role in gemcitabine chemoresistence. MiR-145 is a tumor suppressor which directly targets p70S6K1 for inhibiting its expression in pancreatic adenocarcinoma, providing new therapeutic scheme. Our findings revealed a new mechanism underlying gemcitabine chemoresistance in pancreatic adenocarcinoma cells
Experimental Quantum Communication Overcomes the Rate-loss Limit without Global Phase Tracking
Secure key rate (SKR) of point-point quantum key distribution (QKD) is
fundamentally bounded by the rate-loss limit. Recent breakthrough of twin-field
(TF) QKD can overcome this limit and enables long distance quantum
communication, but its implementation necessitates complex global phase
tracking and requires strong phase references which not only add to noise but
also reduce the duty cycle for quantum transmission. Here, we resolve these
shortcomings, and importantly achieve even higher SKRs than TF-QKD, via
implementing an innovative but simpler measurement-device-independent QKD which
realizes repeater-like communication through asynchronous coincidence pairing.
Over 413 and 508 km optical fibers, we achieve finite-size SKRs of 590.61 and
42.64 bit/s, which are respectively 1.80 and 4.08 times of their corresponding
absolute rate limits. Significantly, the SKR at 306 km exceeds 5 kbit/s and
meets the bitrate requirement for live one-time-pad encryption of voice
communication. Our work will bring forward economical and efficient intercity
quantum-secure networks.Comment: 29 pages, 10 figures, 3 table
Hexa-μ2-acetato-1:2κ4 O:O′;1:2κ2 O:O;2:3κ4 O:O′;2:3κ2 O:O-bis(2-amino-7-chloro-5-methyl-1,8-naphthyridine)-1κN 1,3κN 1-trizinc(II)
The title complex, [Zn3(C2H3O2)6(C9H8ClN3)2], contains three ZnII atoms bridged by six acetate ligands. The central ZnII ion, located on an inversion centre, is surrounded by six O atoms from acetate ligands in a distorted octahedral geometry [Zn—O = 1.9588 (12)–2.1237 (12) Å]. The terminal ZnII ions are coordinated by one N atom of 2-amino-7-chloro-5-methyl-1,8-naphthyridine and three O atoms of three acetate ligands in a distorted tetrahedral geometry. The separation between the central and terminal ZnII ions is 3.245 (3) Å
Tetra-μ-benzoato-κ8 O:O′-bis[(benzoic acid-κO)nickel(II)]
The title compound, [Ni2(C7H5O2)4(C7H6O2)2], is composed of two NiII ions, four bridging benzoate anions and two η1-benzoic acid molecules. The [Ni2(PhCOO)4] unit adopts a typical paddle-wheel conformation. The center between the two NiII atoms represents a crystallographic center of inversion. In addition, each NiII ion also coordinates to one O atom from a benzoic acid molecule. The crystal packing is realised by intermolecular hydrogen-bonding interactions and π–π stacking interactions, with a centroid–centroid distance of 3.921 (1) Å
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