Modelling Work Effort of Workers in the Crowdsourcing Intermediary Market

This study examines crowdsourcing task characteristics (skill variety, task identity, task significance, autonomy, feedback, and task clarity) and the online work situation factor; that is, the trust in evaluations on work effort in the crowdsourcing intermediary market. An e-questionnaire was released as a crowdsourcing task on the Time Fortune website in China; data from 231 valid questionnaires were analyzed using SmartPLS 3 software. Results show that under the conditions of this study, crowdsourcing workers’ internal motivation has a significant positive relationship with their effort. Task autonomy and feedback have significant and positive relationship with internal motivation. Skill variety, task significance, task clarity, and task identity have no significant correlation with internal motivation. However, task clarity has a significant and positive relationship with work effort. The study also finds that the effect of workers’ trust in the task requester on work effort is mediated by internal motivation

Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4

Background: The transcription factor interferon regulatory factor 4 (IRF4) was identified to be involved in human pigmentation by genome-wide association studies (GWASs). The rs12203592-[T/C], which is located in intron 4 of IRF4, shows the strongest link to these pigmentation phenotypes including freckling, sun sensitivity, eye and hair color. Previous studies indicated a functional cooperation of IRF4 with Microphthalmia-associated transcription factor (MITF), a causing gene of Waardenburg syndrome (WS), to synergistically trans-activate Tyrosinase (TYR). However, the underlying mechanism is still unknown. Methods: To investigate the importance of DNA binding in the synergic effect of IRF4. Reporter plasmids with mutant TYR promoters was generated to locate the IRF4 DNA binding sites in the Tyrosinase minimal promoter. By building MITF and IRF4 truncated mutations plasmids, the necessary regions of the synergy functions of these two proteins were also located. Results: The cooperative effect between MITF and IRF4 was specific for TYR promoter. The DNA-binding of IRF4 was critical for the synergic function. IRF4 DNA binding sites in TYR promoter were identified. The Trans-activation domains in IRF4 (aa134-207, aa300-420) were both important for the synergic function, whereas the auto-mask domain (aa207-300) appeared to mask the synergic effect. Mutational analysis in MITF indicated that both DNA-binding and transcriptional activation domains were both required for this synergic effect. Conclusions: Here we showed that IRF4 potently synergized with MITF to activate the TYR promoter, which was dependent on DNA binding of IRF4. The synergic domains in both IRF4 and MITF were identified by mutational analysis. This identification of IRF4 as a partner for MITF in regulation of TYR may provide an important molecular function for IRF4 in the genesis of melanocytes and the pathogenic mechanism in WS

On Routing Optimization in Networks with Embedded Computational Services

Modern communication networks are increasingly equipped with in-network computational capabilities and services. Routing in such networks is significantly more complicated than the traditional routing. A legitimate route for a flow not only needs to have enough communication and computation resources, but also has to conform to various application-specific routing constraints. This paper presents a comprehensive study on routing optimization problems in networks with embedded computational services. We develop a set of routing optimization models and derive low-complexity heuristic routing algorithms for diverse computation scenarios. For dynamic demands, we also develop an online routing algorithm with performance guarantees. Through evaluations over emerging applications on real topologies, we demonstrate that our models can be flexibly customized to meet the diverse routing requirements of different computation applications. Our proposed heuristic algorithms significantly outperform baseline algorithms and can achieve close-to-optimal performance in various scenarios.Comment: 16 figure

Poly[[[silver(I)-μ-1,4-bis­[(imidazol-1-yl)meth­yl]benzene-κ2 N 3:N 3′-silver(I)-μ-1,4-bis­[(imidazol-1-yl)meth­yl]benzene-κ2 N 3:N 3′] 4,4′-diazenediyldibenzoate] dihydrate]

In the title compound, [Ag2(C14H14N4)2](C14H8N2O4)·2H2O, each of the two unique Ag+ ions is two-coordinated by two N atoms from two different 1,4-bis­[(imidazol-1-yl)meth­yl]benzene ligands in an almost linear fashion [N—Ag—N = 170.34 (10) and 160.25 (10)°]. The 4,4′-diazenediyldibenzoate anions do not coordinate to Ag. O—H⋯O hydrogen bonds stabilize the crystal structure

Investigation of the interaction between indigotin and two serum albumins by spectroscopic approaches

AbstractThe binding characteristics of indigotin with human serum albumin (HSA) and bovine serum albumin (BSA) have been investigated by various spectroscopic techniques. Spectroscopic analysis revealed that the quenching mechanism between indigotin and HSA/BSA belonged to the static quenching. The displacement experiments suggested that indigotin primarily bound to tryptophan residues on proteins within site I. The thermodynamic parameters indicated that the binding of indigotin–HSA/BSA mainly depended on the hydrophobic interaction. The binding distance of indigotin to HSA/BSA was evaluated. The results by synchronous fluorescence, three-dimensional fluorescence, Fourier Transform Infrared spectroscopy (FT-IR) and circular dichroism (CD) spectra showed that the conformation of proteins altered in the presence of indigotin

A Toy Model for Magnetic Connection in Black-Hole Accretion Disc

A toy model for magnetic connection in black hole (BH) accretion disc is discussed based on a poloidal magnetic field generated by a single electric current flowing around a Kerr black hole in the equatorial plane. We discuss the effects of the coexistence of two kinds of magnetic connection (MC) arising respectively from (1) the closed field lines connecting the BH horizon with the disc (henceforth MCHD), and (2) the closed field lines connecting the plunging region with the disc (henceforth MCPD). The magnetic field configuration is constrained by conservation of magnetic flux and a criterion of the screw instability of the magnetic field. Two parameters and are introduced to describe our model instead of resolving the complicated MHD equations. Compared with MCHD, energy and angular momentum of the plunging particles are extracted via MCPD more effectively, provided that the BH spin is not very high. It turns out that negative energy can be delivered to the BH by the plunging particles without violating the second law of BH thermodynamics, however it cannot be realized via MCPD in a stable way.Comment: 11 pages, 9 figures, accepted by MNRA