Flexible wavelength-, pulse-controlled mode-locked all-fiber laser based on a fiber Lyot filter

In this paper, we report a flexible wavelength-, pulse-controlled mode-locked all-fiber laser based on a novel fiber optic Lyot filter. The wavelength, pulse duration and spectral bandwidth of passive mode-locked lasers can be tuned by controlling the polarization controller. The proposed Lyot filter was constructed by a single-mode fiber insertion between two polarization-maintaining fibers. The filter bandwidth and laser output tunability were based on the birefringence characteristics of the polarization-maintaining fibers. This all-fiber laser is simple and stable and can be used for various applications where width-tunable or wavelength-tunable pulses are necessary

Coordination Strategy for a New Retail Supply Chain Based on Combination Contract

The supply chain in the new retail context demands higher requirements on the price, service, and logistics level. It is very important to seek the coordination among the optimal price, service level, and logistics level. In this paper, we propose the coordination of pricing, the service level, and delivery time of a new retail supply chain composed of one product supplier, one platform service provider, and one logistics provider. Firstly, the profit function mode of product pricing, platform service level, and logistics distribution level that influence the consumers’ demand is constructed in two modes, namely, the centralized and decentralized decision mode. Then, we calculate and compare the optimal product price, the optimal platform service level, the optimal delivery time, and the profit of each member of the supply chain from both decision modes. We discovered that cooperation improves the service level, logistics level, and the income of each member of the new retail supply chain. Therefore, we propose a novel mode called the coordination mode as a strategy for the supply chain based on the combination contract. We performed a numerical analysis to demonstrate the feasibility and effectiveness of the coordination contract

Operation characteristics of DC transmission system with large-scale renewable energy integration

Marked with flexible interconnection and control, the high-voltage direct current (HVDC) gird has captured much attention of industries and academics. Hybrid dual-infeed or multi-infeed HVDC composed of line-commutated-converter HVDC (LCC-HVDC) and voltage source converter HVDC (VSC-HVDC) will form the main pattern in a further power grid; meanwhile, the new gird pattern will bring new opportunities and challenges to security and stability control in the power system. First, research works on the control strategies and operation performances of LCC-HVDC and VSC-HVDC are stated in this paper; then, a model of wind power integration into a dual-infeed DC transmission system is established in PowerFactory, and case studies are conducted in both steady and transient states. On this basis, a new control strategy for variable-speed constant-frequency wind power generators to promote voltage characteristics of the DC network is designed in this paper, and two additional active power control segments are designed in the traditional control system; thus, DC voltage stability can be improved by fast regulation of active power output due to quick power adjustment of wind power generators; simulations are implemented and the results will lay a foundation for safe and stable operation in the DC transmission system with renewable energy integration

Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local

Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or aminobisphosphonate inhibitors of farnesyldiphosphate synthase. Activated cells are potent for killing a broad range of tumor cells and demonstrated the capacity for tumor reduction in murine xenotransplant tumor models. Translating these findings to the clinic produced promising initial results but greater potency is needed. Here, we review the literature on gamma delta T cells in cancer therapy with emphasis on the Vγ9Vδ2 T cell subset. Our goal was to examine obstacles preventing effective Vγ9Vδ2 T cell therapy and strategies for overcoming them. We focus on the potential for local activation of Vγ9Vδ2 T cells within the tumor environment to increase potency and achieve objective responses during cancer therapy. The gamma delta T cells and especially the Vγ9Vδ2 T cell subset, have the potential to overcome many problems in cancer therapy especially for tumors with no known treatment, lacking tumor-specific antigens for targeting by antibodies and CAR-T, or unresponsive to immune checkpoint inhibitors. Translation of amazing work from many laboratories studying gamma delta T cells is needed to fulfill the promise of effective and safe cancer immunotherapy

Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and ORC1

Abstract Background The study purpose was to make investigation into the influence of XIST on cervical cancer progression and what’s more its potential mechanism. Methods The cervical cancer data sets (lncRNA, miRNA, and mRNA) obtained from TCGA were analyzed with the “mixOmics” R package. Then, the expression of XIST, miR-140-5p, and ORC1 were detected using qRT-PCR and western blot in both tissues and cervical cancer cell lines (Hela and C33A) to verify the bioinformatics analyses results. CCK-8 assay, 5-ethynyl-2′-deoxyuridine (EdU) assays, cell cycle assay and cell apoptosis assay were practiced. Besides, immunohistochemistry staining was operated for the detection of the Ki-67, E-cadherin and vimentin expression in cervical cancer tissues and the apoptosis-related proteins expression (c-caspase3, Bcl-2, total PARP and cleaved PARP) was verified through western blot. And in vivo experiments were implemented. Results MiR-140-5p was down-regulated but XIST and ORC1 were up-regulated in cervical cancer tissues and cell lines. Knocking down of the XIST or ORC1 memorably suppressed cell proliferation, blocked cell cycle, decreased the expression of Bcl-2 while increased the apoptosis rate and the expression of c-caspase3 and cleaved PARP in HeLa and C33A cells. Besides, the results of immunohistochemistry staining showed knocking down the expression of XIST improved the expression levels of E-cadherin and decreased Ki-67 and vimentin expression. And overexpression of miR-140-5p also could inhibit the progression and reverse the influence of XIST and ORC1 in HeLa and C33A cells. Conclusion Our study indicated the effects of XIST/miR-140-5p/ORC1 axis on the progression of cervical cancer which will shed new light on epigenetic diagnostics and therapeutics in cervical cancer

FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway

F-box/WD repeat-containing protein 5 (FBXW5) is a member of the FBXW subclass of F-box proteins. Despite its known function as a component of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex, the role of FBXW5 in gastric cancer tumorigenesis and metastasis has not been investigated. The present study investigates the role of FBXW5 in tumorigenesis and metastasis, as well as the regulation of key signaling pathways in gastric cancer; using in-vitro FBXW5 knockdown/overexpression cell line and in-vivo models. In-vitro knockdown of FBXW5 results in a decrease in cell proliferation and cell cycle progression, with a concomitant increase in cell apoptosis and caspase-3 activity. Furthermore, knockdown of FBXW5 also leads to a down regulation in cell migration and adhesion, characterized by a reduction in actin polymerization, focal adhesion turnover and traction forces. This study also delineates the mechanistic role of FBXW5 in oncogenic signaling as its inhibition down regulates RhoA-ROCK 1 (Rho-associated protein kinase 1) and focal adhesion kinase (FAK) signaling cascades. Overexpression of FBXW5 promotes in-vivo tumor growth, whereas its inhibition down regulates in-vivo tumor metastasis. When considered together, our study identifies the novel oncogenic role of FBXW5 in gastric cancer and draws further interest regarding its clinical utility as a potential therapeutic target

Tectonic setting of the South China Block in the early Paleozoic: Resolving intracontinental and ocean closure models from detrital zircon U-Pb geochronology

Zircon U-Pb geochronological data on over 900 zircon grains for Cambrian to Silurian sandstone samples from the South China Block constrain the pre-Devonian tectonic setting of, and the interrelationships between, the constituent Cathaysia and Yangtze blocks. Zircons range in age from 3335 to 465 Ma. Analyses from the Cathaysia sandstone samples yield major age clusters at similar to 2560, similar to 1850, similar to 1000, and 890-760 Ma. Zircons from the eastern and central Yangtze sandstone samples show a similar age distribution with clusters at similar to 2550, similar to 1860, similar to 1100, and similar to 860-780 Ma. A minor peak at around 1450 Ma is also observed in the Cathaysia and central Yangtze age spectra, and a peak at similar to 490 Ma represents magmatic zircons from Middle Ordovician sandstone in the eastern Yangtze and Cathaysia blocks. The Cambrian and Ordovician strata show a transition from a carbonate-dominated succession in the central Yangtze Block, to an inter-stratified carbonate-siliciclastic succession in the eastern Yangtze Block, to a neritic siliciclastic succession in the Cathaysia Block. Paleocurrent data across this succession consistently indicate directions toward the W-NNW, from the Cathaysia Block to the Yangtze Block. Our data, together with other geological constraints, suggest that the Cathaysia Block constitutes a fragment on the northern margin of east Gondwana and both Cathaysia and east Gondwana constituted the source for the analyzed early Paleozoic samples. The similar age spectra for the Cambrian to Silurian sandstone samples from the Yangtze and Cathaysia blocks argue against the independent development and spatial separation of these blocks in the early Paleozoic but rather suggest that the sandstone units accumulated in an intracontinental basin that spanned both blocks. Subsequent basin inversion and Kwangsian orogenesis possibly at 400-430 Ma also occurred in an intracontinental setting probably in response to the interaction of the South China Block with the Australian-Indian margin of east Gondwana. Citation: Wang, Y., F. Zhang, W. Fan, G. Zhang, S. Chen, P. A. Cawood, and A. Zhang (2010), Tectonic setting of the South China Block in the early Paleozoic: Resolving intracontinental and ocean closure models from detrital zircon U-Pb geochronology, Tectonics, 29, TC6020, doi:10.1029/2010TC002750.</p