The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance

Multiple myeloma (MM) is one of the most important clonal malignant plasma cell disorders and renal involvement is associated with poor prognosis. Although there are several reasons for renal impairment in MM, the main cause is the toxic effects of monoclonal proteins. Although cast nephropathy is the best known and unchallenged diagnosis for hematologists and pathologists, the renal effects of monoclonal gammopathy can be various. Monoclonal gammopathy of renal significance was proposed by the International Kidney and Monoclonal Gammopathy Research Group for renal lesions in monoclonal gammopathy in recent years. Renal lesions in monoclonal gammopathy can be grouped as follows: light chain (cast) nephropathy, acute tubular injury/necrosis, tubulointerstitial nephritis, amyloidosis, monoclonal Ig deposition diseases, immunotactoid glomerulopathy, type I cryoglobulinemia, proliferative glomerulonephritis with monoclonal IgG deposits, C3 glomerulopathy with monoclonal gammopathy, and crystal-storing histiocytosis, considering the previous and new terminology. In this study, renal involvement of monoclonal gammopathies, in terms of previous and new terminology, was reviewed

The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance.

Multiple myeloma (MM) is one of the most important clonal malignant plasma cell disorders and renal involvement is associated with poor prognosis. Although there are several reasons for renal impairment in MM, the main cause is the toxic effects of monoclonal proteins. Although cast nephropathy is the best known and unchallenged diagnosis for hematologists and pathologists, the renal effects of monoclonal gammopathy can be various. Monoclonal gammopathy of renal significance was proposed by the International Kidney and Monoclonal Gammopathy Research Group for renal lesions in monoclonal gammopathy in recent years. Renal lesions in monoclonal gammopathy can be grouped as follows: light chain (cast) nephropathy, acute tubular injury/necrosis, tubulointerstitial nephritis, amyloidosis, monoclonal Ig deposition diseases, immunotactoid glomerulopathy, type I cryoglobulinemia, proliferative glomerulonephritis with monoclonal IgG deposits, C3 glomerulopathy with monoclonal gammopathy, and crystal-storing histiocytosis, considering the previous and new terminology. In this study, renal involvement of monoclonal gammopathies, in terms of previous and new terminology, was reviewed

Intrauterine fetal loss associated with Candida glabrata chorioamnionitis: Report of two cases İntrauterin fetal kayıp ile ilişkili Kandida glabrata koryoamniyoniti: İki olgu sunumu

Chorioamnionitis is most commonly the result of an ascending infection caused by bacteria found within the lower genital tract. Yeast infections causing chorioamnionitis are very uncommon. Candida glabrata is a yeast that is considered to be a commensal of the vagina but vaginitis and rarely upper genital tract infection have been described. We report two cases of fungal chorioamnionitis occurring in pregnancies with a history of in vitro fertilization and cervical cerclage, both resulting in fetal loss. The histological features in conjunction with the positive cultures enabled C. glabrata to be identified as the causative organism producing severe chorioamnionitis. C. glabrata was probably introduced into the cervix at the time of embryo transfer, and during stitching the cervix. To prevent unfavorable outcomes in pregnant women, we recommend that vaginal and in particular cervical swabs should be taken prior to cervical procedures and appropriate treatment should be provided

Childhood intracranial germinoma with granulomatous reaction Granülomatöz reaksiyonun eşlik ettiǧi çocukluk çaǧi i̇ntrakraniyal germinomu

Central nervous system tumors are the second most common type of childhood cancer in Turkey. Germinomas constitute two thirds of intracranial germ cell tumors. The granulomatous inflammation occurring around germinomas can cause histological diagnostic difficulty. We present a 12-year-old girl with a diagnosis of germinoma in the corpus callosum associated with granulomatous reaction to emphasize the diagnostic challenge which may occur during stereotactic biopsy interpretation or intraoperative consultation

TAILGUT CYST WITH SEROMUCOUS GLANDULAR STRUCTURES: CASE REPORT

Retrorektal bölgede izlenen gelişimsel kistler tür, köken ve histopatolojik özelliklerinegöre epidermoid kist, rektal duplikasyon (enterik) kisti ve retrorektal kistik hamartoma("tailgut kisti") olarak sınıflandırılabilir. Bu kistler benign gelişimsel lezyonlar olmaklabirlikte, nadir de olsa malign dönüşüm bildirilmektedir. Bu nedenle klinik olarak erkentanı çok önemlidir. Nadir görülen bu lezyonlar patolog için de ayırıcı tanı açısındansıkıntı yaratabilir. Embriyolojik hindgut kalıntılarından gelişen tailgut kistleri genelliklemultikistik olup, skuamöz epitel, silli kolumnar epitel ya da transisyonel epitel iledöşelidir. Literatürde kist duvarında organize bez yapısı tanımlanan olgu bulunmamaktadır.Burada, altmış sekiz yaşında retrorektal kitlesi bulunan ve histopatolojiktanısı tailgut kisti ile uyumlu, kist duvarında serömüköz bezler bulunan bir olgusunulmuş ve retrorektal gelişimsel kistlerin ayırıcı tanısı tartışılmıştır.Developmental cysts in the retrorectal region can be classified as epidermoid, rectalduplication (enteric) cyst and cystic hamartoma (\"tailgut cyst\"), according to the originand histopathologic features. These cysts are benign developmental lesions, althoughmalignant transformation has been rarely reported. Therefore, early diagnosis isimportant. Because they are rare, differential diagnosis of these lesions may causetrouble for the pathologist. Tailgut cyst develops from embriologic hindgut andusually occurs as a multiloculated cyst lined by squamous, transitional, or glandularepithelium.Here in, we present a sixty-eight year old man with organized glandular structures ofthe cyst wall. To the best of our knowledge, this is the first reported tailgut cyst, withorganized glandular structures, seromocous glands