Defense Against REST-based Web Service Attacks for Enterprise Systems

In recent years, Representational State Transfer or REST-based Web Services have become popular for building Web systems. They have become an integral and critical part of information systems to facilitate and integrate the business processes across the enterprise. However, the simplicity of a REST-based implementation has caused the neglect of its systematic security threat analysis and design. One of the issues of systems built with REST services integration is their susceptibility to JSON input attacks. Such attacks could compromise the integrity of critical data in enterprise business processes. We analyze such a security issue in this paper. Some mechanisms used to secure Web sites and servers, such as encryption via HTTPS, static source code analysis, and input validation, can be integrated to defend against the attack

Merging an e-Business Solution Framework with CIS Curriculum

Since corporations first started conducting business on the Internet in 1993, it has moved quickly from being a curious spectacle to a matter of survival for most businesses. To achieve successful results in this on-line business environment on a consistent basis, companies need to rely on two critical success factors. First, a robust framework to guide the design and implementation of e-Business strategy is crucial. Second, if companies are interested in e-Business applications that are robust, flexible, scalable, maintainable, and platform-independent then the development environment used to design, implement, and deploy such applications is more critical than ever before. These characteristics will gain importance as corporations begin migrating e-Business applications from the traditional Web-based environment to a wireless, mobile, hand-held, and pervasive computing paradigm. A consequence of such ongoing changes in the information technology field will require Computer Information Systems (CIS) departments to regularly update curriculum to ensure that students are imparted with the conceptual knowledge and technical skills expected by the IT industry. This paper describes an e-Business solution framework, and analyzes the impact of the technological and e-business evolution on an existing CIS curriculum in the College of Business at a university in the state of Texas. It discusses the new curriculum developed and implemented in response to these technology changes. Finally, the paper also describes some of the challenges of implementing the new model and the resultant impact

Measurement of (n,γ) reaction cross section of 186W-isotope at neutron energy of 20.02±0.58 MeV

The cross-section of 186W(n,γ)187W reaction has been measured at an average neutron energy of 20.02±0.58 MeV by using activation technique. The 27Al(n,α)24Na and 115In(n,n´)115mIn reactions have been used for absolute neutron flux measurement. Theoretically the reaction cross-sections have been calculated by using the TALYS-1.9 code. The results from the present work and the EXFOR based literature data have been compared with the evaluated data and calculated data from TALYS-1.9 code

Measurement of (n,γ) reaction cross section of 186W-isotope at neutron energy of 20.02±0.58 MeV

392-396The cross-section of 186W(n,γ)187W reaction has been measured at an average neutron energy of 20.02±0.58 MeV by using activation technique. The 27Al(n,α)24Na and 115In(n,n´)115mIn reactions have been used for absolute neutron flux measurement. Theoretically the reaction cross-sections have been calculated by using the TALYS-1.9 code. The results from the present work and the EXFOR based literature data have been compared with the evaluated data and calculated data from TALYS-1.9 code

The Genetic Basis of Hepatosplenic T-cell Lymphoma

Hepatosplenic T cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy number alterations in the disease. Chromatin modifying genes including SETD2, INO80 and ARID1B were commonly mutated in HSTL, affecting 62% of cases. HSTLs manifest frequent mutations in STAT5B (31%), STAT3 (9%), and PIK3CD (9%) for which there currently exist potential targeted therapies. In addition, we noted less frequent events in EZH2, KRAS and TP53. SETD2 was the most frequently silenced gene in HSTL. We experimentally demonstrated that SETD2 acts as a tumor suppressor gene. In addition, we found that mutations in STAT5B and PIK3CD activate critical signaling pathways important to cell survival in HSTL. Our work thus defines the genetic landscape of HSTL and implicates novel gene mutations linked to HSTL pathogenesis and potential treatment targets

Neutron induced reaction cross section of

The cross section of the $$^{51}$$V$$\left( {{{n, p}}} \right) ^{51}$$Ti reaction was measured at 7.87, 13.05 and 16.98 MeV neutron energies using the activation technique and offline $$\gamma$$-ray spectrometry. Vanadium targets were activated along with Al monitor foil to measure the cross section relative to the standard $$^{27}$$Al$$\left( {{{n,\alpha }}} \right) ^{24}$$Na reference reaction. The quasi-monoenergetic neutron beams were produced via the $$^{7}$$Li$$\left( {{{p, n}}} \right)$$ reaction at the 14UD BARC-TIFR Pelletron Facility, Mumbai, India. Statistical nuclear reaction Talys (ver. 1.9) code was used for the theoretical estimations of the $$^{51}$$V$$\left( {{{n, p}}} \right) ^{51}$$Ti reaction cross section. Additionally, the effects of different input parameters were considered in present work to reproduction of the experimental data more accurately. The experimental data of the present measurements were discussed and compared with the previous measurements taken from the EXFOR compilation and latest evaluations of the ENDF/B-VIII.0, JENDL/AD-2017 and TENDL-2019 libraries. The covariance method was used to estimate the magnitudes of the uncertainties in the present cross section measurements. Furthermore, the different systematic formulae at 14–15 MeV energies were used to calculate the $$\left( {{{n, p}}}\right) \!, \left( {{{n, 2n}}} \right)$$ and $$\left( {{{n, \alpha }}} \right)$$ reactions cross section for structural material vanadium. The calculated cross sections from the formulae were discussed and compared with the available experimental data

Exposure of progressive immune dysfunction by SARS-CoV-2 mRNA vaccination in patients with chronic lymphocytic leukemia: A prospective cohort study.

BackgroundPatients with chronic lymphocytic leukemia (CLL) have reduced seroconversion rates and lower binding antibody (Ab) and neutralizing antibody (NAb) titers than healthy individuals following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA vaccination. Here, we dissected vaccine-mediated humoral and cellular responses to understand the mechanisms underlying CLL-induced immune dysfunction.Methods and findingsWe performed a prospective observational study in SARS-CoV-2 infection-naïve CLL patients (n = 95) and healthy controls (n = 30) who were vaccinated between December 2020 and June 2021. Sixty-one CLL patients and 27 healthy controls received 2 doses of the Pfizer-BioNTech BNT162b2 vaccine, while 34 CLL patients and 3 healthy controls received 2 doses of the Moderna mRNA-1273 vaccine. The median time to analysis was 38 days (IQR, 27 to 83) for CLL patients and 36 days (IQR, 28 to 57) for healthy controls. Testing plasma samples for SARS-CoV-2 anti-spike and receptor-binding domain Abs by enzyme-linked immunosorbent assay (ELISA), we found that all healthy controls seroconverted to both antigens, while CLL patients had lower response rates (68% and 54%) as well as lower median titers (23-fold and 30-fold; both p 23-fold and >17-fold lower median NAb titers (both p 2.4 mg/L), prior therapy, anti-CD20 immunotherapy (ConclusionsCLL pathogenesis is characterized by a progressive loss of adaptive immune functions, including in most treatment-naïve patients, with preexisting memory being preserved longer than the capacity to mount responses to new antigens. In addition, higher NAb titers and response rates identify mRNA-1273 as a superior vaccine for CLL patients

Research Needs for Inpatient Management of Severe Alcohol Withdrawal Syndrome An Official American Thoracic Society Research Statement

Background: Severe alcohol withdrawal syndrome (SAWS) is highly morbid, costly, and common among hospitalized patients, yet minimal evidence exists to guide inpatient management. Research needs in this field are broad, spanning the translational science spectrum. Goals: This research statement aims to describe what is known about SAWS, identify knowledge gaps, and offer recommendations for research in each domain of the Institute of Medicine T-0-T-4 continuum to advance the care of hospitalized patients who experience SAWS. Methods: Clinicians and researchers with unique and complementary expertise in basic, clinical, and implementation research related to unhealthy alcohol consumption and alcohol withdrawal were invited to participate in a workshop at the American Thoracic Society 2019 International Conference. The committee was subdivided into four groups on the basis of interest and expertise: T-0-T-1 (basic science research with translation to humans), T-2 (research translating to patients), T-3 (research translating to clinical practice), and T-4 (research translating to communities). A medical librarian conducted a pragmatic literature search to facilitate this work, and committee members reviewed and supplemented the resulting evidence, identifying key knowledge gaps. Results: The committee identified several investigative opportunities to advance the care of patients with SAWS in each domain of the translational science spectrum. Major themes included 1) the need to investigate non-g-aminobutyric acid pathways for alcohol withdrawal syndrome treatment; 2) harnessing retrospective and electronic health record data to identify risk factors and create objective severity scoring systems, particularly for acutely ill patients with SAWS; 3) the need for more robust comparative-effectiveness data to identify optimal SAWS treatment strategies; and 4) recommendations to accelerate implementation of effective treatments into practice. Conclusions: The dearth of evidence supporting management decisions for hospitalized patients with SAWS, many of whom require critical care, represents both a call to action and an opportunity for the American Thoracic Society and larger scientific communities to improve care for a vulnerable patient population. This report highlights basic, clinical, and implementation research that diverse experts agree will have the greatest impact on improving care for hospitalized patients with SAWS