Defense Against REST-based Web Service Attacks for Enterprise Systems

In recent years, Representational State Transfer or REST-based Web Services have become popular for building Web systems. They have become an integral and critical part of information systems to facilitate and integrate the business processes across the enterprise. However, the simplicity of a REST-based implementation has caused the neglect of its systematic security threat analysis and design. One of the issues of systems built with REST services integration is their susceptibility to JSON input attacks. Such attacks could compromise the integrity of critical data in enterprise business processes. We analyze such a security issue in this paper. Some mechanisms used to secure Web sites and servers, such as encryption via HTTPS, static source code analysis, and input validation, can be integrated to defend against the attack

Merging an e-Business Solution Framework with CIS Curriculum

Since corporations first started conducting business on the Internet in 1993, it has moved quickly from being a curious spectacle to a matter of survival for most businesses. To achieve successful results in this on-line business environment on a consistent basis, companies need to rely on two critical success factors. First, a robust framework to guide the design and implementation of e-Business strategy is crucial. Second, if companies are interested in e-Business applications that are robust, flexible, scalable, maintainable, and platform-independent then the development environment used to design, implement, and deploy such applications is more critical than ever before. These characteristics will gain importance as corporations begin migrating e-Business applications from the traditional Web-based environment to a wireless, mobile, hand-held, and pervasive computing paradigm. A consequence of such ongoing changes in the information technology field will require Computer Information Systems (CIS) departments to regularly update curriculum to ensure that students are imparted with the conceptual knowledge and technical skills expected by the IT industry. This paper describes an e-Business solution framework, and analyzes the impact of the technological and e-business evolution on an existing CIS curriculum in the College of Business at a university in the state of Texas. It discusses the new curriculum developed and implemented in response to these technology changes. Finally, the paper also describes some of the challenges of implementing the new model and the resultant impact

Understanding Health-Seeking Behavior of People with Diabetes during COVID-19 Pandemic: A Facility Based Cross-Sectional Study Conducted in Ahmedabad, India

Objective: The study was conducted to understand health-seeking behavior (HSB) of people with diabetes during the coronavirus disease 2019 (COVID-19) pandemic. Materials and methods: A hospital-based cross-sectional study was conducted at All India Institute of Diabetes and Research (AIIDR), Swasthya Diabetes Care in Ahmedabad, India. Data were collected with the help of a structured questionnaire. Response rate was 97%. One hundred thirty-eight participants who visited the hospital during the month of May 2022 were included and interviewed after obtaining informed consent.Results: Of the study participants (n = 138), 43.5% were female, while 56.5% were male. The mean age of study participants was 51.22. Out of 138 participants, 18.1% (n = 25) had type 1 diabetes mellitus (T1D) and 81.9% (n = 113) had type 2 diabetes mellitus (T2D). It was found that 55.7% faced delay in regular checkups, 39.8% used telemedicine to avoid travelling to hospital in fear of getting COVID infection, 7.8% faced delay in consuming medicines due to unavailability of medicines. Regular intake of medicines/insulin altered for 40.5% of study participants. 54.3% of our study participants felt fear while visiting the laboratory to measure their blood glucose level. Conclusions: Uncertainties created by COVID-19 pandemic have affected HSB of people with diabetes in terms of access to healthcare facilities, medicine adherence, laboratory testing, self-management habits. Knowledge shared here can help program planners to identify influencing factors and implement appropriate interventions. This understanding also helps in setting the stage for the formulation of effective diabetesrelated educational programs which might help for future pandemic

Measurement of (n,γ) reaction cross section of 186W-isotope at neutron energy of 20.02±0.58 MeV

The cross-section of 186W(n,γ)187W reaction has been measured at an average neutron energy of 20.02±0.58 MeV by using activation technique. The 27Al(n,α)24Na and 115In(n,n´)115mIn reactions have been used for absolute neutron flux measurement. Theoretically the reaction cross-sections have been calculated by using the TALYS-1.9 code. The results from the present work and the EXFOR based literature data have been compared with the evaluated data and calculated data from TALYS-1.9 code

Measurement of (n,γ) reaction cross section of 186W-isotope at neutron energy of 20.02±0.58 MeV

392-396The cross-section of 186W(n,γ)187W reaction has been measured at an average neutron energy of 20.02±0.58 MeV by using activation technique. The 27Al(n,α)24Na and 115In(n,n´)115mIn reactions have been used for absolute neutron flux measurement. Theoretically the reaction cross-sections have been calculated by using the TALYS-1.9 code. The results from the present work and the EXFOR based literature data have been compared with the evaluated data and calculated data from TALYS-1.9 code

The Genetic Basis of Hepatosplenic T-cell Lymphoma

Hepatosplenic T cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy number alterations in the disease. Chromatin modifying genes including SETD2, INO80 and ARID1B were commonly mutated in HSTL, affecting 62% of cases. HSTLs manifest frequent mutations in STAT5B (31%), STAT3 (9%), and PIK3CD (9%) for which there currently exist potential targeted therapies. In addition, we noted less frequent events in EZH2, KRAS and TP53. SETD2 was the most frequently silenced gene in HSTL. We experimentally demonstrated that SETD2 acts as a tumor suppressor gene. In addition, we found that mutations in STAT5B and PIK3CD activate critical signaling pathways important to cell survival in HSTL. Our work thus defines the genetic landscape of HSTL and implicates novel gene mutations linked to HSTL pathogenesis and potential treatment targets

Validation and Investigation of the Four Aspects of Cycle Regression: A New Algorithm for Extracting Cycles

The cycle regression analysis algorithm is the most recent addition to a group of techniques developed to detect "hidden periodicities." This dissertation investigates four major aspects of the algorithm. The objectives of this research are 1. To develop an objective method of obtaining an initial estimate of the cycle period? the present procedure of obtaining this estimate involves considerable subjective judgment; 2. To validate the algorithm's success in extracting cycles from multi-cylical data; 3. To determine if a consistent relationship exists among the smallest amplitude, the error standard deviation, and the number of replications of a cycle contained in the data; 4. To investigate the behavior of the algorithm in the predictions of major drops

Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature Review

Background. Given limited data on the epidemiology of MSI-H and dMMR across solid tumors (except colorectal cancer (CRC)), the current study was designed to estimate their prevalence. Materials and Methods. A structured literature review identified English language publications that used immunohistochemistry (IHC) or polymerase chain replication (PCR) techniques. Publications were selected for all tumors except CRC using MEDLINE, EMBASE, and Cochrane databases and key congresses; CRC and pan-tumor genomic publications were selected through a targeted review. Meta-analysis was performed to estimate pooled prevalence of MSI-H/dMMR across all solid tumors and for selected tumor types. Where possible, prevalence within tumor types was estimated by disease stages. Results. Of 1,176 citations retrieved, 103 and 48 publications reported prevalence of MSI-H and dMMR, respectively. Five pan-tumor genomic studies supplemented the evidence base. Tumor types with at least 5 publications included gastric (n = 39), ovarian (n = 23), colorectal (n = 20), endometrial (n = 53), esophageal (n = 6), and renal cancer (n = 8). Overall MSI-H prevalence (with 95% CI) across 25 tumors was based on 90 papers (28,213 patients) and estimated at 14% (10%–19%). MSI-H prevalence among Stage 1/2 cancers was estimated at 15% (8%–23%); Stages 3 and 4 prevalence was estimated at 9% (3%–17%) and 3% (1%–7%), respectively. Overall, dMMR prevalence across 13 tumor types (based on 54 papers and 20,383 patients) was estimated at 16% (11%–22%). Endometrial cancer had the highest pooled MSI-H and dMMR prevalence (26% and 25% all stages, respectively). Conclusions. This is the first comprehensive attempt to report pooled prevalence estimates of MSI-H/dMMR across solid tumors based on published data. Prevalence determined by IHC and PCR was generally comparable, with some variations by cancer type. Late-stage prevalence was lower than that in earlier stages