Data-Driven Discovery of a New Fluorescent BASHY Dye for Bioimaging

Fluorescent molecules play a crucial role in biomedicine by facilitating the visualization and tracking of biological processes with sensitivity and specificity. However, tailoring their structure to meet the demands of live cell and in vivo imaging presents a significant challenge due to the intricate interplay of factors governing their structural and photophysical properties. In this study, we explored the potential of using multivariate linear free-energy relationships (mLFER) to optimize a multicomponent fluorescent platform. We prepared a small library of 20 fluorescent boronic-acid-derived salicylidenehydrazone (BASHY) complexes using a versatile reaction protocol and characterized their chemical stability in water-containing media. The obtained data served as input for the development of an mLFER model, enabling the prediction of a new BASHY dye and unraveling previously unknown mechanisms governing the stability of this unique platform of fluorescent dyes. The optimized dye was successfully employed in live cell experiments and in zebrafish larvae

Bangladesh’s Flooding: Coping Strategies of Flood Affected People of Nageshwari Upazila

Flood is one of the most common natural disasters in Southeast Asia, especially in Bangladesh. Extreme flood inundates more than half of the developing country’s landmass causing immense suffering to human life, damages properties, and economy. Furthermore, flood protection and management have been emphasized in terms of the sustainable development approach against climate impacts. As a result, Bangladesh has developed distinct indigenous practices to protect themselves from floods. The study aimed to identify the coping mechanisms and indigenous knowledge and the barriers to using these mechanisms.  The study was conducted in two unions named Ratanpur and Nunkhawa of Nageshwari Upazila which is an Upazila of Kurigram District of Bangladesh. The study was based on. A mixed-method was used for the study. The survey questionnaire, focus group discussion (FGD) and key informants’ interviews (KII) were used as the tools for collecting data. Most of the respondents were farmers who had very minimal income level. Even though respondents used the shelter center during the flood incident, selling assents, letting children work, multiple works, extra labor were the fundamental strategies to overcome financial damage. The most common challenges faced by the victims to overcome the situation were the financial scarcity and recovering wasted crops. Filing to recover the vulnerability made some of the respondents migrate to another city or place. Proper money lending and credit system at reasonable or without interest rate, Instant food, and pure water supply can facilitate their mechanism.</jats:p

Opvoeddebatten met migrantenvaders: Een methodiekbeschrijving en -onderbouwing

De methodiek ‘Opvoeddebatten met migrantenvaders’ is ontwikkeld door Trias Pedagogica. De debatten hebben als doel om vaders die niet zo snel worden bereikt door formele opvoedondersteuning met elkaar te laten nadenken en discussiëren over hun vaderschap. Aanvullend krijgen zij kennis over opvoeding en ontwikkeling aangereikt. De methodiek is oorspronkelijk ontwikkeld voor Marokkaanse vaders, maar wordt inmiddels ook uitgevoerd met vaders van andere etnische achtergronden

Centrosome positioning and development of ciliopathies: role of the human centrosomal protein TBCCD1

Place: Philadelphia Publisher: Lippincott Williams & Wilkins WOS:00052586560010

A qualitative study into the perceptions and needs of fathers with a migration background on parenting regarding energy balance-related behaviors

Abstract Background Overweight among adolescents is worldwide still considered a serious public health problem. Although both parents influence children’s energy balance-related behavior, most studies have predominantly focused on mothers and white populations. Therefore, in this study, we contribute to the research by exploring the perceptions and needs of Dutch fathers with a migration background on parenting, specifically regarding promoting healthy energy balance-related behaviors among their children, and what motivates fathers to participate in parenting programs focused on these behaviors. Methods We used a qualitative research design. Informal conversations (n = 2), semi-structured interviews (n = 11) and one focus group (n = 13) were conducted with professionals specialized in intercultural pedagogy and fathers participating in a parenting program organized by these professionals. Interviews and focus group were audio-recorded and transcribed. Atlas.ti 8 was used for theme detection, categorization, and classification using inductive and deductive approaches. The data was analyzed using grounded theory analysis. Results Fathers joined parenting programs to improve their parenting skills and knowledge and address health and socio-cultural challenges. Furthermore, intergenerational differences were evident: second-generation fathers were more proactive in tackling parenting challenges related to healthy lifestyles. Fathers highlighted challenges related to parenting in two cultures. Although participating in the parenting program facilitated fathers in adopting a healthier lifestyle for both themselves and their families, improving communication with family members, and experiencing changes regarding gender dynamics within their household, influencing their teenage children, to adopt healthier habits remained a challenge, especially in comparison to younger children. Conclusions A deeper understanding of the needs, perceptions, and experiences of migrant populations concerning parenting regarding the promotion of healthy energy balance-related behaviors among their children can lead to better-tailored health promotion programs that prioritize cultural and linguistic inclusivity