Joint Scheduling and ARQ for MU-MIMO Downlink in the Presence of Inter-Cell Interference

User scheduling and multiuser multi-antenna (MU-MIMO) transmission are at the core of high rate data-oriented downlink schemes of the next-generation of cellular systems (e.g., LTE-Advanced). Scheduling selects groups of users according to their channels vector directions and SINR levels. However, when scheduling is applied independently in each cell, the inter-cell interference (ICI) power at each user receiver is not known in advance since it changes at each new scheduling slot depending on the scheduling decisions of all interfering base stations. In order to cope with this uncertainty, we consider the joint operation of scheduling, MU-MIMO beamforming and Automatic Repeat reQuest (ARQ). We develop a game-theoretic framework for this problem and build on stochastic optimization techniques in order to find optimal scheduling and ARQ schemes. Particularizing our framework to the case of "outage service rates", we obtain a scheme based on adaptive variable-rate coding at the physical layer, combined with ARQ at the Logical Link Control (ARQ-LLC). Then, we present a novel scheme based on incremental redundancy Hybrid ARQ (HARQ) that is able to achieve a throughput performance arbitrarily close to the "genie-aided service rates", with no need for a genie that provides non-causally the ICI power levels. The novel HARQ scheme is both easier to implement and superior in performance with respect to the conventional combination of adaptive variable-rate coding and ARQ-LLC.Comment: Submitted to IEEE Transactions on Communications, v2: small correction

A Graphene-based Hot Electron Transistor

We experimentally demonstrate DC functionality of graphene-based hot electron transistors, which we call Graphene Base Transistors (GBT). The fabrication scheme is potentially compatible with silicon technology and can be carried out at the wafer scale with standard silicon technology. The state of the GBTs can be switched by a potential applied to the transistor base, which is made of graphene. Transfer characteristics of the GBTs show ON/OFF current ratios exceeding 50.000.Comment: 18 pages, 6 figure

Two Randomized Trials Provide No Consistent Evidence for Nonmusical Cognitive Benefits of Brief Preschool Music Enrichment

Young children regularly engage in musical activities, but the effects of early music education on children’s cognitive development are unknown. While some studies have found associations between musical training in childhood and later nonmusical cognitive outcomes, few randomized controlled trials (RCTs) have been employed to assess causal effects of music lessons on child cognition and no clear pattern of results has emerged. We conducted two RCTs  with preschool children investigating the cognitive effects of a brief series of music classes, as  compared to a similar but non-musical form of arts instruction (visual arts classes, Experiment 1) or to a no-treatment control (Experiment 2). Consistent with typical preschool arts enrichment programs, parents attended classes with their children, participating in a variety of developmentally appropriate arts activities. After six weeks of class, we assessed children’s skills  in four distinct cognitive areas in which older arts-trained students have been reported to excel: spatial-navigational reasoning, visual form analysis, numerical discrimination, and receptive vocabulary. We initially found that children from the music class showed greater spatial-navigational ability than did children from the visual arts class, while children from the visual arts class showed greater visual form analysis ability than children from the music class (Experiment 1). However, a partial replication attempt comparing music training to a no-treatment control failed to confirm these findings (Experiment 2), and the combined results of  the two experiments were negative: overall, children provided with music classes performed no better than those with visual arts or no classes on any assessment. Our findings underscore the need for replication in RCTs, and suggest caution in interpreting the positive findings from past studies of cognitive effects of music instruction.Psycholog

Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory.

The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.The authors acknowledge financial support from EPSRC, Geistlich Pharma AG and ERC Advanced Grant 320598 3D-E.This is the final version of the article. It first appeared from Wiley at http://dx.doi.org/10.1002/adhm.201500197

Thermostable allergens in canned fish: Evaluating risks for fish allergy

Background: Major fish allergens, including parvalbumin (PV), are heat stable and can withstand extensive cooking processes. Thus, the management of fish allergy generally relies on complete avoidance. Fish-allergic patients may be advised to consume canned fish, as some fish-allergic individuals have reported tolerance to canned fish. However, the safety of consuming canned fish has not been evaluated with comprehensive immunological and molecular analysis of canned fish products. Methods: We characterized the in vitro immunoreactivity of serum obtained from fish-allergic subjects to canned fish. Seventeen canned fish products (salmon n = 8; tuna n = 7; sardine n = 2) were assessed for the content and integrity of PV using allergen-specific antibodies. Subsequently, the sIgE binding of five selected products was evaluated for individual fish-allergic patients (n = 53). Finally, sIgE-binding proteins were identified by mass spectrometry. Results: The canned fish showed a markedly reduced PV content and binding to PV-specific antibodies compared with conventionally cooked fish. However, PV and other heat-stable fish allergens, including tropomyosin and collagen, still maintained their sIgE-binding capacity. Of 53 patients, 66% showed sIgE binding to canned fish proteins. The canned sardine contained proteins bound to sIgE from 51% of patients, followed by canned salmon (43%–45%) and tuna (8%–17%). PV was the major allergen in canned salmon and sardine. Tropomyosin and/or collagen also showed sIgE binding. Conclusion: We showed that canned fish products may not be safe for all fish-allergic patients. Canned fish products should only be considered into the diet of individuals with fish allergy, after detailed evaluation which may include in vitro diagnostics to various heat-stable fish allergens and food challenge conducted in suitable environments

Influence of an active T-foil on motions and passenger comfort of a large high‑speed wave‑piercing catamaran based on sea trials

T-foil and stern tabs were installed on a wave-piercing catamaran (Incat Tasmania Hull 061) to improve ship motions and passenger comfort. More than 40 total effective hours of sea trials were conducted by the US Navy in 2004, encountering sea states 4-5 in the Atlantic Ocean near the United Kingdom. In this paper the influence of a ride-control system (RCS) on the heave and pitch response amplitude operator (RAO) of the full-scale high-speed catamaran was investigated using the sea trial data. The reduction in motion sickness incidence (MSI) was estimated in order to examine the effectiveness of the RCS in improving passenger comfort. With the existing control algorithm, the vertical accelerations were found to be best controlled by the active T-foil working together with the active stern tabs, while the pitch RAO was mainly mitigated by deploying only the stern tabs. About a 23% reduction was observed in the peak heave RAO with deployment of an active T-foil. The MSI can be reduced by up to 23% with respect to the cases with stern tabs only, depending on the encountered wave conditions, based on ISO recommendation for MSI calculation of a 2-h seaway passage

Commercial shellfish skin prick test extracts show critical variability in allergen repertoire

[Extract] Crustacean and mollusc (shellfish) allergy affects up to 3% of the general population, is usually lifelong and commonly triggers anaphylaxis.1 Allergen repertoire diversity among hundreds of edible shellfish species worldwide is poorly reflected in available in vivo and in vitro diagnostic tools for shellfish allergy. Skin prick testing (SPT) is often the preferred first-line diagnostic approach. However, widely utilized commercial SPT extracts are generally not standardized, limiting the diagnostic value of results.2 Asero et al. reported a heterogeneous abundance of three shellfish allergens in five commercial crustacean SPT extracts, resulting in 32 clinical profiles among 157 shrimp-allergic patients.3 In 2019, we demonstrated considerable variability in allergen repertoire and IgE-binding for 27 commercial fish SPT extracts.4 We now report an even greater, critical variability for 11 commercial crustacean and five mollusc SPT extracts, utilizing biochemical and immunological methods and mass spectrometry (see Appendix S1 for methodology and TableS1 for allergen extract details)

Leptonic μ \mu - and τ \tau -decays: mass effects, polarization effects and O(α) O(\alpha) radiative corrections

We calculate the radiative corrections to the unpolarized and the four polarized spectrum and rate functions in the leptonic decay of a polarized $\mu$ into a polarized electron. The new feature of our calculation is that we keep the mass of the final state electron finite which is mandatory if one wants to investigate the threshold region of the decay. Analytical results are given for the energy spectrum and the polar angle distribution of the final state electron whose longitudinal and transverse polarization is calculated. We also provide analytical results on the integrated spectrum functions. We analyze the $m_e \to 0$ limit of our general results and investigate the quality of the $m_e \to 0$ approximation. In the $m_e \to 0$ case we discuss in some detail the role of the $O(\alpha)$ anomalous helicity flip contribution of the final electron which survives the $m_e \to 0$ limit. The results presented in this 0203048 also apply to the leptonic decays of polarized $\tau$-leptons for which we provide numerical results.Comment: 39 pages, 11 postscript figures added. Updated version. Four references added. A few text improvements. Final version to appear in Phys.Rev.

The first reptilian allergen and major allergen for fish-allergic patients: Crocodile β-parvalbumin

Background: Clinical cross-reactivity between bony fish, cartilaginous fish, frog, and chicken muscle has previously been demonstrated in fish-allergic patients. In indicative studies, two reports of anaphylaxis following the consumption of crocodile meat and IgE-cross-binding were linked to the major fish allergen parvalbumin (PV). This study investigates IgE-binding proteins in crocodile meat with a focus on PV and their clinical relevance. Methods: Proteins were extracted from muscle tissue of crocodile, three bony fish, and two cartilaginous fish. A cohort of fish-allergic pediatric patients (n = 77) underwent allergen skin prick testing (SPT) to three fish preparations (n = 77) and crocodile (n = 12). IgE-binding proteins were identified and quantified by SDS-PAGE, mass spectrometric analyses, and immunoblotting using commercial and in-house antibodies, as well as individual and pooled patients’ serum. PV isoforms were purified or recombinantly expressed before immunological analyses, including human mast cell degranulation assay. Results: Of the tissues analyzed, PV was most abundant in heated crocodile preparation, triggering an SPT of ≥3 mm in 8 of 12 (67%) fish-allergic patients. Seventy percent (31 of 44) of fish PV-sensitized patients demonstrated IgE-binding to crocodile PV. Crocodile β-PV was the major IgE-binding protein but 20-fold less abundant than α-PV. Cellular reactivity was demonstrated for β-PV and epitopes predicted, explaining frequent IgE-cross-binding of β-PVs. Both PV isoforms are now registered as the first reptile allergens with the WHO/IUIS (β-PV as Cro p 1 and α-PV as Cro p 2). Conclusion: Fish-allergic individuals may be at risk of an allergy to crocodile and should seek specialist advice before consuming crocodilian meat