REMITTING SERONEGATIVE SYMMETRICAL SYNOVITIS WITH PITTING EDEMA (RS3PE) SYNDROME AND MALIGNANCY

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ORIGINAL ARTICLE - ANTITHYROID ANTIBODY LEVELS IN PATIENTS WITH BREAST CANCER

Breast cancer is a hormone-dependent neoplasm. Conflicting results regarding the clinical correlation between breast cancer and thyroid diseases have been reported. The aim of this study was to determine the goiter prevalence, thyroid hormones and antithyroid antibody levels in patients with breast cancer. For this purpose, thyroid ultrasonography was performed and serum levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibodies (anti-TPO ab) and anti-thyroglobulin antibodies (anti-TG ab) were determined in 50 operable breast cancer patients at the time of diagnosis and 30 healthy individuals as control group. Goiter prevalence was found to be significantly higher in the study group (50% vs 10%). FT3, FT4, and TSH levels of patients were not different compared to controls, whereas anti-TPO ab and anti-TG ab levels were significantly higher in patients than in the control group. In conclusion, goiter prevalence and thyroid antibody levels were found to be increased in breast cancer patients and thyroid functions should be monitored

RHEUMATOID ARTHRITIS AND PULMONARY CARCINOID TUMOR

A 40-year old woman was admitted with a history of elbow, wrist, knee pain and prolonged morning stiffness. Rheumatoid arthritis (RA) diagnosed before five years, had been treated with non-steroidal anti-inflammatory agents and low dose corticosteroid. On hospital admission, routine chest x-ray showed a 4x4 cm solitary mass in the right pulmonary. A diagnostic thoracotomy was performed. The histological examination showed a typical carcinoid tumor. This is the third carcinoid tumor case reported to be associated with RA

Gaucher disease: two case

Gaucher hastalığı beta glukoserobrozidaz genindeki mutasyon sonucunda gelişen, otozomal resesif kalıtımla geçen, lipit depo hastalığıdır. Mutasyon sonucunda enzim aktivitesindeki azalma sonucunda retikuloendotelial sistemde makrofajlarda glukoserobrozid birikimi olur. Nörolojik komponenti olup (tip 2 ve 3) olmamasına (tip 1) göre klinik üç subtipi vardır. Hastalar sıklıkla hepatosplenomegali, anemi, trombositopeni ve kemik ağrıları vardır. Biz birinde siroz gelişmiş iki tip 1 Gaucher hastasını sunduk.Gaucher's disease is an autosomal recessive glycolipid storage disorder caused by mutations in the beta glucocerebrosidase gene. This defect leads to reduced enzyme activity with accumulation of glucocerebroside in the macrophages of the reticuloendothelial system. Three clinical subtypes of Gaucher's disease have been described on the basis of the absence (type I) or presence (types II and III) of a neurological component. Type I is the more common subtype. Common presenting features include hepatosplenomegaly, anemia, thrombocytopenia, and often bone pains. We present two cases with Gaucher disease type 1, one of whom also had cirrhosis

Evaluation of cardiac influences in patients with type II diabetes mellitus by tissue Doppler imaging

Amaç: Diyabetik kardiyomiyopati, koroner arter hastalığı (KAH) ve hipertansiyondan bağımsız olarak diyabetes mellitus (DM)'a bağlı gelişen primer kardiyak fonksiyon bozukluğu olarak tanımlanır. Doku Doppler görüntüleme (DDG) miyokardiyal hızların ölçülmesiyle sol ventrikülün (LV) sistolik ve diyastolik fonksiyonlarının segmenter olarak değerlendirilmesine izin veren yeni ve üstün bir tekniktir. Çalışmamızda DM'un LV fonksiyonlarına etkisini DDG yöntemiyle incelenmesi amaçlandı. Gereç ve Yöntem: Çalışmaya 60 Tip II Diyabetli hasta (36 kadın, 24 erkek; yaş ort:49.3±8.8 yıl) dahil edildi. Standart M-Mod, mitral inflow, pulmoner venöz akım hızları yanında, DDG yöntemiyle off-line mitral anulus, LV segmental miyokardiyal hızları ve hız zaman değişkenleri ölçüldü. Bulgular: DM grubunda LV sistolik, diyastolik çapları ve hacimleri azalmış, duvar kalınlıkları ve kitlesi artmıştı. Global sistolik fonksiyon göstergeleri normaldi. DM grubunda A velositesi artmış, EDZ ve IRT uzamış, pulmoner ven sistolik dalga hızı azalmıştı. DDG'de S velositeleri her iki grupta benzerdi. DM hastalarında E' velositesi azalmış, A' artmış, IRT' ve EDZ' uzamış olarak saptandı Sonuç: KAH ve hipertansiyonu olmayan DM'lu olgular DDG ile incelendiğinde, diyastolik fonksiyonlarda sol ventrikülün bazı segmentlerinde daha belirgin olmak üzere bozulma gelişmektedir.Aim: Diabetic cardiomyopathy is defined as primary cardiac dysfunction due to diabetes mellitus (DM) independent of coronary artery disease (CAD) and hypertension. Tissue Doppler imaging (TDI) is a recently developed unique technique that allows assessment of regional left ventricular (LV) systolic and diastolic functions by measurements of myocardial velocities. In our study, we aimed to investigate the effect of DM on LV functions by using TDI. Material and Method: Sixty patients with Type II DM (36 female, 24 male, mean age: 49.3±8.8 yrs) were included into the study. As well as standard M-Mode, mitral inflow and pulmonary venous flow velocities, we also measured off-line mitral annulus and LV segmentary myocardial velocities and velocity time intervals by TDI method. Results: LV diastolic and systolic diameters and volumes were found to be decreased and wall thickness and mass increased in diabetic group. Global systolic function parameters were normal. In diabetic group, A velocity was increased, EDT and IRT were prolonged and pulmonary venous systolic velocity decreased. In TDI evaluation, S velocities of both groups were similar. In patients with DM, E' velocities were decreased, A' was increased and IRT' and EDT' were prolonged. Conclusion: When diabetic patients not having CAD or hypertension evaluated by TDI, it was observed that diastolic functions were impaired and this impairment was more prominent in some segments of LV

The IL-33 gene is related to increased susceptibility to systemic sclerosis

Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both in vitro and in vivo settings; moreover, increased level of IL-33 has also been reported in patients with SSc. Therefore, the aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. A total of 300 SSc patients and 280 healthy controls (HC) were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. There was no significant difference in terms of the allelic distributions and minor allele frequencies of evaluated four IL-33 polymorphisms between the SSc and HC groups (P > 0.05 for all). Moreover, the genotypic distributions of rs1157505, rs11792633 and rs1929992 polymorphisms were not significantly different (P > 0.05 for all). However, CC genotype of rs7044343 SNP was significantly higher in the SSc group compared to the HC group (P = 0.013, OR 1.75, 95 % CI 1.12-2.72). This preliminary candidate gene study demonstrates that rs7044343 polymorphism of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc

Real-world data on change in work productivity, activity impairment, and quality of life in patients with psoriatic arthritis under anti-TNF therapy: a postmarketing, noninterventional, observational study

Objectives To understand change in work productivity, activity impairment, quality of life (QoL), and disease activity in patients with psoriatic arthritis (PsA) receiving anti-tumor necrosis factor (anti-TNF) treatment.Method One hundred twenty patients with PsA receiving anti-TNF therapy were recruited to this noninterventional, observational study. Work disability was assessed via the Work Productivity and Activity Impairment (WPAI) questionnaire and disease activity was calculated via the 28-joint Disease Activity Score using C-reactive protein (DAS28-CRP) and Disease Activity Index for Psoriatic Arthritis with 28 joints (DAPSA28) score. Patient-reported outcomes (PROs), from visual analog scores and Health Assessment Questionnaire-Disability Index scores, were evaluated to understand the clinical effectiveness at baseline and every 3 months until the month-9 final visit. The American College of Rheumatology (ACR)20/50/70 response criteria were assessed at month 9.Results A total of 120 patients (females, n = 73) were enrolled in the study. Mean (SD) age and disease duration were 41.6 +/- 11.1 years and 6.9 +/- 6.5 years, respectively. The most commonly used TNF alpha inhibitor was adalimumab (42.4%), followed by etanercept (25.8%). All WPAI questionnaire parameters were reduced at the follow-up visits compared with baseline (p < 0.001 for all). PROs and disease activity indicators (DAS28-CRP and DAPSA28) significantly improved during the course of anti-TNF treatments (p < 0.001 for all). Additionally, ACR20/50/70 responses were determined as 86.8%, 63.7%, and 41.8% of patients at the month-9 visit.Conclusions The real-world data in PsA patients receiving anti-TNF treatment showed improvement in WPAI, QoL, and disease activity over 9 months of treatment.AbbVi

The impact of ankylosing spondylitis in Turkey on productivity at work outside home and within the household

Bu çalışma, 06-11, Kasım 2015 tarihlerinde San Francisco[Amerika]’da düzenlenen Annual Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) Kongresi‘nde bildiri olarak sunulmuştur.Amer Coll RheumatolAssoc Rheumatol Hlth Profes