6 research outputs found

    High prolidase levels in patients with Familial Mediterranean Fever (FMF)

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    Introduction. Familial Mediterranean Fever (FMF) is an autoinflammatory disease. Prolidase is a specific imidodipeptidase that plays a role in collagen degradation, and an important role in inflammation and wound healing. Hypoxia-inducible factor-1α (HIF-1) is an important protein in the regulation of immunological response, hemostasis, vascularization. The aim of the study was to compare serum prolidase and HIF-1α levels in patients with FMF in attack-free period and healthy control group

    A trend analysis of Sars-Cov-2 anti-nucleocapsid IgG antibodies with a recommendation of the cut-off classification to identify naïve, vaccinated, and infected cases

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    Determination of the vaccination's effect on immune responses with the emergence of the Sars-Cov-2 pandemic become an important issue. This study aimed to evaluate the response of the anti-nucleocapsid IgG (anti-N IgG) index in naïve, vaccinated, or infected cases, in addition to suggesting ‘How to distinguish between vaccinated versus infected cases via anti-N IgG?'. Anti-N levels of the naïve [0.03 (0.02–0.06)], vaccinated [0.7 (0.2–1.96)], and infected [3.07 (1.44–5.2)] groups were statistically different (p [Med-Science 2022; 11(4.000): 1534-40

    Demographic, clinical and laboratory characteristics for differential diagnosis of peripheral lymphadenopathy (LAP) and the etiologic distribution of LAP in adults; a multicenter, nested case-control study including 1401 patients from Turkey

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    Peripheral lymphadenopathy (LAP) is an important and common abnormal finding of the physical exam in general medical practice. We aimed to reveal the LAP etiology and demographic, clinical and laboratory variables that may be useful in the differential evaluation of LAP. This multicenter, nested case-control study including 1401 patients between 2014 and 2019 was conducted in 19 tertiary teaching and research hospitals from different regions in Turkey. The ratio of infectious, malign and autoimmune/inflammatory diseases was 31.3%, 5% and 0.3%, respectively. In 870 (62%) of patients had nonspecific etiology. Extrapulmonary tuberculosis (n: 235, 16.8%) was the most frequent cause of LAP. The ratio of infective etiology of LAP was significantly lower in patients older than 65 years-old compared to younger patients with the rate of 66.67% and 83.84%, respectively (p 0.016, OR 0.386, 95% Cl 0.186-0.803). The probability of malign etiology was higher both in patients who are older than 45 years-old (p < 0.001, OR 3.23, 95% Cl 1.99-5.26) and older than 65 years-old (p 0.002, OR 3.36, 95% Cl 1.69-6.68). Age, localization and duration of LAP, leukocytosis, anemia, thrombocytopenia, CRP and sedimentation rate were important parameters to differentiate infections. Size of lymph node and splenomegaly in addition to the parameters above were useful parameters for differentiating malign from benign etiology. Despite the improvements in diagnostic tools, reaching a definite differential diagnosis of lymphadenopathy is still challenging. Our results may help clinicians to decide in which cases they need an aggressive workup and set strategies on optimizing the diagnostic approach of adulthood lymphadenopathy

    Kültürel Bellek 2017

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    KÜLTÜREL BELLEK 2017 kitabımızda, 7-8-9 Kasım 2017'de üniversitemizin Bilimsel Araştırma Projeleri Koordinasyon Birimi'nin desteğiyle gerçekleştirdiğimiz sempozyumdan seçilmiş yazılar ve konuyla ilgili olduğunu düşündüğümüz araştırma yazıları toplanmıştır. Başta Hacettepe Üniversitesi olmak üzere Ankara Üniversitesi, Anadolu Üniversitesi, Orta Doğu Teknik Üniversitesi, Hacı Bayram Veli Üniversitesi, TED Üniversitesi, Çankaya Üniversitesi gibi Ankara'daki üniversiteler ile Tekirdağ Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, Balıkesir Üniversitesi, Nevşehir Üniversitesi, Sakarya Üniversitesi, Özyeğin Üniversitesi gibi ülkemizin farklı kentlerindeki üniversitelerden ve Varşova Üniversitesi'nden araştırmacıların çalışmalarını biraraya getirmekten mutluyuz. Disiplinlerarası yaklaşımı ve farklı bakış açılarını birleştirmeyi amaçladığımız bu seçkide sanat tarihi, psikoloji, halkbilimi, arkeoloji gibi insani bilimler alanlarından, Türk dili ve edebiyatı, Fransız dili ve edebiyatı, İngiliz dili ve edebiyatı, İtalyan dili ve edebiyatı gibi filoloji alanlarından, seramik, mimarlık, şehir ve bölge planlama gibi güzel sanatlar ve mimarlık fakültelerinden, psikiyatri ve nöroloji gibi tıp alanlarından araştırma yazıları yer almaktadır. Unutmamak için biz hatırlamayı, öğrenmeyi, görmeyi, araştırmayı seçiyoruz. Unutmamak için, unutulduysa hatırlamak ve hatırlatmak için, bilmeyenlere göstermek, anlatmak ve belleğimize sahip çıkmak için başladığımız bu yolculukta çağrımızı kırmayan değerli araştırmacılara şükranlarımızı sunuyoruz. Unutmayalım ki, kültürel bellek hepimizi birleştiren güçtür

    9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

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