Microsatellite Support for Active Inbreeding in a Cichlid Fish

In wild animal populations, the degree of inbreeding differs between species and within species between populations. Because mating with kin often results in inbreeding depression, observed inbreeding is usually regarded to be caused by limited outbreeding opportunities due to demographic factors like small population size or population substructuring. However, theory predicts inclusive benefits from mating with kin, and thus part of the observed variation in inbreeding might be due to active inbreeding preferences. Although some recent studies indeed report kin mating preferences, the evidence is still highly ambiguous. Here, we investigate inbreeding in a natural population of the West African cichlid fish Pelvicachromis taeniatus which showed clear kin mating preferences in standardized laboratory experiments but no inbreeding depression. The presented microsatellite analysis reveals that the natural population has, in comparison to two reference populations, a reduced allelic diversity (A = 3) resulting in a low heterozygosity (Ho = 0.167) pointing to a highly inbred population. Furthermore, we found a significant heterozygote deficit not only at population (Fis = 0.116) but also at subpopulation level (Fis = 0.081) suggesting that inbreeding is not only a by-product of population substructuring but possibly a consequence of behavioral kin preferences

Angioimmunoblastic T-cell lymphoma unmasked by treatment with dupilumab

No abstrac

Engineering Daten Management fuer kleine und mittelstaendische Unternehmen Schwerpunktthema des CIM TT Suhl. Abschlussbericht

The publication gives a general overview about the subject of EDM systems that emphasises on the closer inspection of the peculiarities of their deployment in small and medium-sized enterprises. Due to the differences to large companies the different requirements to EDM systems as well as to strategies of their introduction are explained. An overview about the EDM market is given and the future development of the systems especially under the influence ot the standard is looked at. Furthermore the publication inclused a description of the EDM systems used in the CIM Technology Transfer (CIM TT) Centre Suhl of the Technical University of Ilmenau and of their utilization in the office work. (orig.)SIGLEAvailable from TIB Hannover: F96B1346+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman