Small heat-shock proteins: important players in regulating cellular proteostasis

Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection. In doing so, they assist in the maintenance of protein homeostasis (proteostasis) thereby avoiding the deleterious effects that result from loss of protein function and/or protein aggregation. The chaperone properties of sHsps are therefore employed extensively in many tissues to prevent the development of diseases associated with protein aggregation. Significant progress has been made of late in understanding the structure and chaperone mechanism of sHsps. In this review, we discuss some of these advances, with a focus on mammalian sHsp hetero-oligomerisation, the mechanism by which sHsps act as molecular chaperones to prevent both amorphous and fibrillar protein aggregation, and the role of post-translational modifications in sHsp chaperone function, particularly in the context of disease.SM was supported by a Royal Society Dorothy Hodgkin Fellowship, HE is supported by an Australian Research Council Future Fellowship (FT110100586) and JC is supported by a National Health and Medical Research Council Project Grant (#1068087)

The Continuing Conundrum of International Internet Jurisdiction

International law has long been concerned with resolving issues of international jurisdiction; however, the unique circumstances involved in Internet cases have thrown a wrench in the traditional machinary of international jurisdiction law. Domestic courts continue to struggle with the issue, and the international community has dragged its feet on developing a uniform standard for determining international Internet jurisdiction. Further complicating matters, states often have divergent substantive Internet regulations and policies. This Note discusses and analyzes the leading cases and theories on international Internet jurisdiction and concludes that none of the current proposed solutions alone provide a satisfactory solution. Nevertheless, an international resolution on internet jurisdiction that borrows elements from each of these proposals could be successfully established

Nucleation and growth control in protein crystallization

The five topics summarized in this final report are as follows: (1) a technique for the expedient, semi-automated determination of protein solubilities as a function of temperature and application of this technique to proteins other than lysozyme; (2) a small solution cell with adjustable temperature gradients for the growth of proteins at a predetermined location through temperature programming; (3) a microscopy system with image storage and processing capability for high resolution optical studies of temperature controlled protein growth and etching kinetics; (4) growth experiments with lysozyme in thermosyphon flow ; and (5) a mathematical model for the evolution of evaporation/diffusion induced concentration gradients in the hanging drop protein crystallization technique

Wear transitions in a wear coefficient model

The frictional-work wear model has been used popularly for the prediction of wear phenomena such as rail corrugation. The accuracy of such models depends on the value chosen for the empirical wear coefficient in this wear model. Experimental results have widely shown that this wear coefficient is strongly dependent upon the type of wear process involved. The wear coefficient in the frictional-work wear model under two-disc contact and dry friction conditions proposed is a multi-step function of the friction power density corresponding to three types of wear. However, at present there is no clear means of predicting the transitions between wear types. This paper investigates wear transitions between the wear types are predicted using analytical models based on the wear mechanics involved

Leadership and Race: How to Develop and Support Leadership that Contributes to Racial Justice

This report explores the ways in which our current thinking about leadership often contributes to producing and maintaining racialized dynamics, and identifies a set of core competencies associated with racial justice leadership. Recommendations are included for helping leadership programs develop and support leadership that furthers racial justice in organizations, communities, and the broader society

What are the educational needs and experiences of asylum-seeking and refugee children, including those who are unaccompanied, with a particular focus on inclusion? - A literature review

In a context of mass displacement and flows of asylum-seeking and refugee peoples across national borders, the need to respond and attend to the education of asylum-seeking and refugee children is urgent and pressing, though it is not without its challenges. This literature review focuses on the educational experiences of asylum seeking and refugee children, including those who are unaccompanied, with a particular focus on inclusion. It seeks to respond to the following three interconnected questions: 1. What does current educational literature tell us about the educational needs and experiences of asylumseeking and refugee children as they relate to inclusion? 2. What does current educational literature tell us about the educational needs and experiences of unaccompanied asylum-seeking and refugee children as they relate to inclusion? 3. What implications and recommendations can be drawn from existing literature? The review has a particular interest in the needs and experiences of unaccompanied asylum-seeking and refugee children, but recognises that though there is a developing literature specifically on unaccompanied asylum seeking and refugee children (see, for example, Stanley, 2001; Derluyn and Broekaert, 2008; Pastoor, 2015) such needs must be understood and positioned in relation to the wider educational needs and experiences of asylum seeking and refugee children more generally. While other literature reviews on asylum-seeking and refugee children are available (see, for example, Hek, 2005; McBrien, 2005), the present review adds to existing work by: • including an explicit focus on the educational needs and experiences of asylum-seeking and refugee children who are unaccompanied; • providing an up-to-date review of literature which analyses and reports the educational needs and experiences of asylum-seeking and refugee children. The review focuses in particular on post-migration experiences within school settings as they relate to asylum seeking and refugee children’s social inclusion

Optimising slew torque on a mining dragline via a four degree of freedom dynamic model

A dynamic model of a dragline is developed in the form of a fundamental nonlinear rotating multibody system with energy dissipation. Its dynamic behaviour is investigated using measured field data. Model predictions of dynamic behaviour and stresses during operation are investigated and a comparison with measured data presented. Preliminary results from an investigation into reducing fatigue duty via improved slew torque control are also presented. The dynamics of the dragline bucket swing motion during house slewing (rotation) are of particular importance for both structural loading and efficient operation

Inclusive educational provision for newly-arrived unaccompanied asylum-seeking and refugee children: a study in a single school in Kent

Recent migration flows – including those resulting from conflict, persecution and natural disaster – place a responsibility on nations to honour international and humanitarian commitments with respect to refugees. A central part of these commitments is to make provision for the educational needs of asylum-seeking and refugee children, including those whom are unaccompanied. Indeed, education and schooling play a crucial role in the complex relationship between newly-arrived immigrants and their new host communities. In the UK and elsewhere a body of research evidence has developed regarding the post-migration educational needs and experiences of asylum-seeking and refugee children. As we have reported elsewhere (Peterson et al., 2016), such research points to a range of approaches, relationships and practices through which asylum-seeking and refugee children are, and indeed at times are not, included within their new communities, including the school community. The study reported here was conducted in a national and local context of increased recognition (both positive and negative) of the humanitarian plight and presence of asylum-seeking and refugee people and children, including children whom are unaccompanied. The study focused on the approach of a single 11-18 school –Hartsdown Academy – situated in Margate, Kent. Working with Virtual School Kent, the school has developed its existing educational provision to include newly-arrived unaccompanied asylum-seeking and refugee children. The present study is concerned particularly with the perceived and actual social and cultural outcomes and benefits (including any notable challenges and barriers) of the school’s approach to including newly-arrived unaccompanied asylum-seeking and refugee children