4 research outputs found
Investigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans.
Collaboration with:
Université d’Orléans, 28000 Chartres, France,
Université de Picardie Jules Verne, F-80037 Amiens, France
De Montfort University
Open access articleLinum flavum hairy root lines were established from hypocotyl pieces using Agrobacterium rhizogenes strains LBA 9402 and ATCC 15834. Both strains were effective for transformation but induction of hairy root phenotype was more stable with strain ATCC 15834. Whereas similar accumulation patterns were observed in podophyllotoxin-related compounds (6-methoxy-podophyllotoxin, podophyllotoxin and deoxypodophyllotoxin), significant quantitative variations were noted between root lines. The influence of culture medium and various treatments (hormone, elicitation and precursor feeding) were evaluated. The highest accumulation was obtained in Gamborg B5 medium. Treatment with methyl jasmonate, and feeding using ferulic acid increased the accumulation of aryltetralin lignans. These results point to the use of hairy root culture lines of Linum flavum as potential sources for these valuable metabolites as an alternative, or as a complement to Podophyllum collected from wild stands
Turbulence induced additional deceleration in relativistic shock wave propagation: implications for gamma-ray burst
The late afterglow of gamma-ray burst is believed to be due to progressive
deceleration of the forward shock wave driven by the gamma-ray burst ejecta
propagating in the interstellar medium. We study the dynamic effect of
interstellar turbulence on shock wave propagation. It is shown that the shock
wave decelerates more quickly than previously assumed without the turbulence.
As an observational consequence, an earlier jet break will appear in the light
curve of the forward shock wave. The scatter of the jet-corrected energy
release for gamma-ray burst, inferred from the jet-break, may be partly due to
the physical uncertainties in the turbulence/shock wave interaction. This
uncertainties also exist in two shell collisions in the well-known internal
shock model proposed for gamma-ray burst prompt emission. The large scatters of
known luminosity relations of gamma-ray burst may be intrinsic and thus
gamma-ray burst is not a good standard candle. We also discuss the other
implications.Comment: accepted for publication in Astrophysics and Space Scienc