RECOGNITION AND RECTIFICATION OF WEB APPLICATION OBLIGATION WITH FIXED ANALYSIS AND TEXT MINING

Possibly, reason for that insecurity of web applications is the fact many programmers lack appropriate understanding about secure coding, so that they leave applications with flaws. This paper explores a technique for instantly protecting web applications and also the programmer informed. The approach consists in analyzing the web application source code searching for input validation vulnerabilities, and inserting fixes within the same code to correct these flaws. research within the configuration within the data mining component, along with an experimental think about the tool with plenty of free PHP applications. The tool may be extended with elevated flaws and databases, however, this set demonstrates the idea. Designing and applying WAP is a challenging task. Unlike our work, other works didn't make an effort to identify bugs and identify their whereabouts, but to evaluate the standard of the program based on the prevalence of defects and vulnerabilities. The tool does taint analysis of PHP programs, a kind of data flow analysis. Within the first four posts available would be the decision tree models. These models select for the tree nodes the attributes which have greater information gain. The C4.5/J48 model prunes the tree to attain better results. The K-NN model has far better performance since the courses are now balanced. However, the kappa, precision, and precision metrics show the Bayes models remain the worst

Low Complex And Reconfigurable Fir Filter Using Low Power Architecture

Coefficient multipliers are the hindrances exhibit in programmable finite impulse response (FIR) advanced channels. As the channel coefficients change either powerfully or occasionally, the scan for basic sub articulations for multiplier less execution should be performed over the whole extent of numbers of the coveted exactness, and the measure of movements related with each recognized basic sub articulation should be retained. The multifaceted nature of a quality inquiry is in this manner past the current outline calculations in light of ordinary double and marked digit portrayals. Another plan worldview for the programmable FIR channels by misusing the expanded twofold base number framework (EDBNS). Because of its sparsity and intrinsic reflection of the whole of parallel moved fractional items, the sharing of adders in the time-multiplexed various consistent increase pieces of the programmable FIR channels can be boosted by an immediate mapping from the semi least EDBNS. The multiplexing cost can be further reduced by merging double base terms. In this, power is reduced by using modified booth encoding algorithm. Partial products generation stage is optimized by using Radix8 modified booth encoding algorithm

Hybrid Spectral-IRDx: Near-IR and Ultrasound Attenuation System for Differentiating Breast Cancer from Adjacent Normal Tissue

OBJECTIVE: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time-consuming and labour-intensive requiring skilled personnel. METHOD: We describe a Hybrid Spectral-IRDx - a combination of the previously reported Spectral-IRDx tool with multimodal ultrasound and NIR spectroscopy techniques. We show how this portable, cost-effective, minimal-contact tool could provide rapid diagnosis of cancer using formalin-fixed (FF) and deparaffinized (DP) breast biopsy tissues. RESULTS: Using this new tool, measurements were performed on cancerous/fibroadenoma and its adjacent normal tissues from the same patients (N=14). The acoustic attenuation coefficient () and reduced scattering coefficient (s) (at 850, 940, and 1060 nm) for the cancerous/fibroadenoma tissues were reported to be higher compared to adjacent normal tissues, a basis of delineation. Comparing FF cancerous and adjacent normal tissue, the difference in s at 850 nm and 940 nm were statistically significant (p=3.17e-2 and 7.94e-3 respectively). The difference in between the cancerous and adjacent normal tissues for DP and FF tissues were also statistically significant (p=2.85e-2 and 7.94e-3 respectively). Combining multimodal parameters and s (at 940 nm) show highest statistical significance (p=6.72e-4) between FF cancerous/fibroadenoma and adjacent normal tissues. CONCLUSION: We show that Hybrid Spectral-IRDx can accurately delineate between cancerous and adjacent normal breast biopsy tissue. SIGNIFICANCE: The results obtained establish the proof-of-principle and large-scale testing of this multimodal breast cancer diagnostic platform for core biopsy diagnosis

Role of Dispersion and Functionalization on Mechanical Properties in Carbon Nanotube - Polymer Composite

Polymer composites with carbon nanotubes (CNT) as filler material is an exciting research area, having a huge potential of offering better mechanical properties. One of the main challenges of using CNT as a filler material is mixing of CNTs within the matrix material, as this mixing determines the strength of the composite. Some of the methods being researched for improving mixing are chemical, mechanical and surfactants. Many studies have suggested high frequency mechanical stirring as the preferred way for better mixing, but challenges exist with finding the proper solvent which can be used for stirring and at the same time doesn\u27t react with the base polymer. Furthermore, the solvent selection is limited by viscosity, evaporation rate and stability after stirring. Functionalization of CNT may also affect the mechanical properties of the composite as functionalization is supposed to help in distribution of CNTs in polymer matrix. For this study multiwalled carbon nanotubes (MWCNT)with different functionalizations(COOH & OH) and polydimethylsiloxane is selected as CNT polymer composite. The objective of this study is to determine an effective solvent for stirring and investigate the role of dispersion on the mechanical properties of the CNT polymer composite. Additionally the secondary objective of this study is to examine how the functionalization helps in enhancing the mechanical properties of CNT polymer composite

A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish

A strategy based on Pd-mediated ring closure of 1,2-disubstituted indoles containing an unactivated olefin leading to indole-1,2- fused 8- and 9-membered rings has been developed for the identification of new and potential scaffolds for apoptosis. A large number of fused indole derivatives containing an endocyclic double bond were synthesized using this robust methodology. A representative compound showed promising apoptotic properties in zebrafish embryos

Mycobacterium tuberculosis Zinc Metalloprotease-1 assists mycobacterial dissemination in Zebrafish

Zinc metalloprotease-1 (Zmp1) from Mycobacterium tuberculosis (M.tb), the tuberculosis (TB) causing bacillus, is a virulence factor involved in inflammasome inactivation and phagosome maturation arrest. We earlier reported that Zmp1 was secreted under granuloma-like stress conditions, induced Th2 cytokine microenvironment and was highly immunogenic in TB patients as evident from high anti-Zmp1 antibody titers in their sera. In this study, we deciphered a new physiological role of Zmp1 in mycobacterial dissemination. Exogenous treatment of THP-1 cells with 500 nM and 1 μM of recombinant Zmp1 (rZmp1) resulted in necrotic cell death. Apart from inducing secretion of necrotic cytokines, TNFα, IL-6, and IL-1β, it also induced the release of chemotactic chemokines, MCP-1, MIP-1β, and IL-8, suggesting its likely function in cell migration and mycobacterial dissemination. This was confirmed by Gap closure and Boyden chamber assays, where Zmp1 treated CHO or THP-1 cells showed ~2 fold increased cell migration compared to the untreated cells. Additionally, Zebrafish-M. marinum based host-pathogen model was used to study mycobacterial dissemination in-vivo. Td-Tomato labeled M. marinum (TdM. marinum) when injected with rZmp1 showed increased dissemination to tail region from the site of injection as compared to the untreated control fish in a dose-dependent manner. Summing up these observations along with the earlier reports, we propose that Zmp1, a multi-faceted protein, when released by mycobacteria in granuloma, may lead to necrotic cell damage and release of chemotactic chemokines by surrounding infected macrophages, attracting new immune cells, which in turn may lead to fresh cellular infections, thus assisting mycobacterial dissemination

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C–N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacological properties when tested in vitro and in zebrafish embryos