On the origin of two unidentified radio/X-ray sources discovered with XMM-Newton

We aim at clarifying the nature of the emission of two spatially related unidentified X-ray sources detected with XMM-Newton telescope at intermediate-low Galactic latitude. Observations reveal a point-like source aligned with elongated diffuse emission. The X-ray spectra are best-fitted by absorbed power laws with photon indices ~1.7 for the point-like and ~2.0 for the extended one. Both sources show nonthermal radio-continuum counterparts that might indicate a physical association. From the available data, we did not detect variability on the point-like source in several timescales. Two possible scenarios are analyzed: first, based on HI line absorption, assuming a Galactic origin, we infer a distance upper bound of <2 kpc, which poses a constraint on the height over the Galactic plane of <200 pc and on the linear size of the system of 10^32 erg/s and >7.5 x 10^32 erg/s, for the point-like and extended sources, respectively; second, an extra-Galactic nature is discussed, where the point-like source might be the core of a radio galaxy and the extended source its lobe. In this case, we compare derived fluxes, spectral indices, and spatial correlation with those typical from the radio galaxy population, showing the feasibility of this alternative astrophysical scenario. From the available observational evidence, we suggest that the most promising scenario to explain the nature of these sources is a system consisting of a one-sided radio galaxy, where the point-like source is an active galactic nucleus and the extended source corresponds to the emission from its lobe. Other possibilities include a PSR/PWN origin, where the radio/X-ray emission originates from the synchrotron cooling of relativistic particles in the PSR magnetic field or a casual alignment between two unrelated sources, such as an AGN core and a Galactic X-ray blob.Comment: 6 pages, 2 figures. Accepted for publication in Astronomy and Astrophysics (A&A

Dynamics of a suspension of interacting yolk-shell particles

In this work we study the self-diffusion properties of a liquid of hollow spherical particles (shells)bearing a smaller solid sphere in their interior (yolks). We model this system using purely repulsive hard-body interactions between all (shell and yolk) particles, but assume the presence of a background ideal solvent such that all the particles execute free Brownian motion between collisions,characterized by short-time self-diffusion coefficients D0s for the shells and D0y for the yolks. Using a softened version of these interparticle potentials we perform Brownian dynamics simulations to determine the mean squared displacement and intermediate scattering function of the yolk-shell complex. These results can be understood in terms of a set of effective Langevin equations for the N interacting shell particles, pre-averaged over the yolks' degrees of freedom, from which an approximate self-consistent description of the simulated self-diffusion properties can be derived. Here we compare the theoretical and simulated results between them, and with the results for the same system in the absence of yolks. We find that the yolks, which have no effect on the shell-shell static structure, influence the dynamic properties in a predictable manner, fully captured by the theory.Comment: 5 pages, 1 figur

THROES: a caTalogue of HeRschel Observations of Evolved Stars. I. PACS range spectroscopy

This is the first of a series of papers presenting the THROES (A caTalogue of HeRschel Observations of Evolved Stars) project, intended to provide a comprehensive overview of the spectroscopic results obtained in the far-infrared (55-670 microns) with the Her- schel space observatory on low-to-intermediate mass evolved stars in our Galaxy. Here we introduce the catalogue of interactively reprocessed PACS (Photoconductor Array Camera and Spectrometer) spectra covering the 55-200 microns range for 114 stars in this category for which PACS range spectroscopic data is available in the Herschel Science Archive (HSA). Our sample includes objects spanning a range of evolutionary stages, from the asymptotic giant branch to the planetary nebula phase, displaying a wide variety of chemical and physical properties. The THROES/PACS catalogue is accessible via a dedicated web-based inter- face (https://throes.cab.inta-csic.es/) and includes not only the science-ready Herschel spectroscopic data for each source, but also complementary photometric and spectroscopic data from other infrared observatories, namely IRAS (Infrared Astronomical Satellite), ISO (Infrared Space Observatory) or AKARI, at overlapping wavelengths. Our goal is to create a legacy-value Herschel dataset that can be used by the scientific community in the future to deepen our knowledge and understanding of these latest stages of the evolution of low-to-intermediate mass stars.Comment: 38 page

Balances de elementos en un agroecosistema de caña de azúcar: I. Balance de nitrógeno

In a tropical mollisol cropped with sugar cane the annual nitrogen balance was quantified taken into account the main i) inputs, ii) outputs and iii) transference of the element (N-NO3 + N-NH4) in the plant and soil subsystems. Precipitation input corresponded to 26.3 kg N.h–1.yr-1 mainly as N-NH4. After the rain water passes the sugar cane canopy there was a retention of N in the N-NH4 form, whereas N-NO3 was leached from the canopy. Outputs through leaching reached 5.3 kg N. ha-1.yr–1 mainly as N-NO3. An important part of total soil N is fixed to the 2:1 type clay particles (montmorillonitic), abundant in the studied mollisol. It is hypothesised that this fixed N could act as a soil N reserve. Net mineralization of the organic-N reached a high value (343 kg N.ha-1.yr–1) in accordance with the intense nitrification process occurring in the soil as a consequence of the convenient C/N ratio and urea fertilisation. Major N losses in the agrosystem correspond to cropping export and removal of ashes after fire. Yearly 98% of N accumulated in the aerial biomass is lost through those ways. In general the annual nitrogen budget is driven off through input by fertilisation and output through stem cropping and N volatilisation by fire

Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing

Directed paths on hierarchical lattices with random sign weights

We study sums of directed paths on a hierarchical lattice where each bond has either a positive or negative sign with a probability $p$. Such path sums $J$ have been used to model interference effects by hopping electrons in the strongly localized regime. The advantage of hierarchical lattices is that they include path crossings, ignored by mean field approaches, while still permitting analytical treatment. Here, we perform a scaling analysis of the controversial ``sign transition'' using Monte Carlo sampling, and conclude that the transition exists and is second order. Furthermore, we make use of exact moment recursion relations to find that the moments always determine, uniquely, the probability distribution $P(J)$. We also derive, exactly, the moment behavior as a function of $p$ in the thermodynamic limit. Extrapolations ($n\to 0$) to obtain for odd and even moments yield a new signal for the transition that coincides with Monte Carlo simulations. Analysis of high moments yield interesting ``solitonic'' structures that propagate as a function of $p$. Finally, we derive the exact probability distribution for path sums $J$ up to length L=64 for all sign probabilities.Comment: 20 pages, 12 figure

Decoupling the effect of mutant amyloid precursor protein (APP) from the effect of plaque on axonal transport dynamics in the living mouse brain: A correlation MRI-microscopy study

The parent protein for amyloid plaques, amyloid precursor protein (APP), mediates cargo‐motor attachments for intracellular transport. Axonal transport is decreased and the distal location of accumulation is altered in transgenic mice expressing human APP with the Swedish and Indiana mutations (APPSwInd) linked to Familial Alzheimer’s Disease, as detected by time‐lapse magnetic resonance imaging (MRI) of transport in living mouse brains (Bearer et al. 2017). Transport is also altered in brains of Down syndrome mice with 3 copies of APP gene. Questions now become whether expression of mutated APP effects transport dynamics independent of plaque, and do plaques alone contribute to transport defects? To address these we used the Tet‐Off system to decouple expression of APPSwInd from presence of plaques, and then studied transport using our MRI technique in three experimental groups of transgenic mice in which the timing and duration of APPSwInd expression, and thereby plaque formation, was altered with doxycycline: Group A (+ plaques, + APPSwInd); Group B (+ plaques, no APPSwInd), and group C (no plaques, + APPSwInd). Manganese‐enhanced MRI (MEMRI) allows us to perform cell biological experiments in live animals with T1‐weighted MRI in a Bruker 11.7T scanner (Medina et al 2016). Time‐lapse MR images were captured before and after stereotactic injection of Mn2+ (3‐5nL) into CA3 of the hippocampus at successive time‐points. Images of multiple individuals were aligned and processed with our automated computational pipeline (Medina et al. 2017) and statistical parametric mapping (SPM) performed. After MRI brains were harvested for histopathology or biochemistry. Results show that within group between time‐point have altered transport locations as well as diminished transport in all groups compared to wildtype (p<0.05 FDR n= 36). Preliminary ANOVA between‐group comparisons both by SPM and by region of interest measurements of images support the visual impression that APPSwInd expression alone may compromise transport. Groups A and B displayed plaques, but not C, and Western blots showed APPSwInd expressed 3.2‐fold over normal at sacrifice in Groups A and C but not B, with Aβ detected only in Groups A and B, where phospho‐tau was also present in dystrophic neurites surrounding plaques. Cholinergic neurons that project to hippocampus from the medial septal nucleus were decreased in Group C (p=0.0006 by ANOVA, n=15). Isolated hippocampal vesicles contained Mn2+, as well as Trk (NGF receptor), Rab 5 and 7 (associated with transport vesicles), suggesting a distinct vesicle population is affected by these APP mutations. These surprising results implicate mutated APPSwInd in transport defects, separable from the effect of plaque