23 research outputs found

    Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study

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    The aim of this study was to evidence the clinical efficacy of an alcohol-free mouthwash containing 5.0% (W/V) Brazilian green propolis (MGP 5%) for the control of plaque and gingivitis. Twenty five subjects, men and women aging between 18 and 60 years old (35 ± 9), were included in a clinical trials phase II study who had a minimum of 20 sound natural teeth, a mean plaque index of at least 1.5 (PI), and a mean gingival index of at least 1.0 (GI). They were instructed to rinse with 10 mL of mouthwash test for 1 minute, immediately after brushing in the morning and at night. After 45 and 90 days using mouthwash, the results showed a significant reduction in plaque and in gingival index when compared to samples obtained in baseline. These reductions were at 24% and 40%, respectively (P < .5). There were no important side effects in soft and hard tissues of the mouth. In this study, the MGP 5% showed evidence of its efficacy in reducing PI and GI. However, it is necessary to perform a clinical trial, double-blind, randomized to validate such effectiveness

    Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study

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    The aim of this study was to evidence the clinical efficacy of an alcohol-free mouthwash containing 5.0% (W/V) Brazilian green propolis (MGP 5%) for the control of plaque and gingivitis. Twenty five subjects, men and women aging between 18 and 60 years old (35 ± 9), were included in a clinical trials phase II study who had a minimum of 20 sound natural teeth, a mean plaque index of at least 1.5 (PI), and a mean gingival index of at least 1.0 (GI). They were instructed to rinse with 10 mL of mouthwash test for 1 minute, immediately after brushing in the morning and at night. After 45 and 90 days using mouthwash, the results showed a significant reduction in plaque and in gingival index when compared to samples obtained in baseline. These reductions were at 24% and 40%, respectively (P &lt; .5). There were no important side effects in soft and hard tissues of the mouth. In this study, the MGP 5% showed evidence of its efficacy in reducing PI and GI. However, it is necessary to perform a clinical trial, double-blind, randomized to validate such effectiveness

    Estudo coorte prospectivo em terapia de manutenção periodontal: análise de parâmetros clínicos periodontais, progressão de periodontite, perda dentária e de modelo multifuncional para avaliação do risco periodontal

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    Exportado OPUSMade available in DSpace on 2019-08-14T08:37:39Z (GMT). No. of bitstreams: 1 tese_telma_artigos_1__2__3_e_4__2008_revisado.pdf: 2182186 bytes, checksum: 008afe3dd0ad822c686ca12051ba081b (MD5) Previous issue date: 23Este estudo de coorte aberto prospectivo teve como objetivo avaliar a progressão da periodontite, a influência de variáveis preditoras de risco e avaliar a incidência e motivos para a ocorrência de perda dentária (PD) em indivíduos inseridos num programa de terapia de manutenção periodontal (TMP) em ambiente universitário. Metodologia: 250 indivíduos com diagnóstico de periodontite crônica moderadaavançada, que finalizaram terapia periodontal ativa foram recrutados na Faculdade de Odontologia da Universidade Federal de Minas Gerais, Brasil. Todosforam submetidos a um exame clínico periodontal completo (TMP1) e a uma coleta de variáveis sociais, demográficas e biológicas de interesse. Avaliou-se o grau de cooperação destes indivíduos (cooperadores, cooperadores irregulares e não cooperadores) quanto à adesão ao programa de TMP em re-chamadas trimestrais (TMP2, TMP3 e TMP4) pelo período de 12 meses. Assim, 150 indivíduos considerados cooperadores completos (60%) foram elegíveis para esta pesquisa. Emtodas as re-chamadas foram coletados os seguintes dados: índice de placa (IP), sangramento a sondagem (SS), profundidade de sondagem (PS), níveis clínicos de inserção (NCI), supuração (S) e envolvimento de furca (EF), em todos dentes presentes (com exceção de terceiros molares). Identificou-se, pela plausibilidade biológica, quais variáveis preditoras de risco poderiam influenciar a condição clínica periodontal e a progressão da periodontite. O efeito de variáveis de interesse econfundimentofoi testado por análise univariada e regressão logística multivariada, assim como motivos e tipos de dentes perdidos. Resultados: Observou-se uma melhora considerável nos parâmetros clínicos periodontais na maioria dos indivíduos. Durante o período de monitoramento, 130 indivíduos (86,7%) tiveram estabilidade periodontal e 20 indivíduos (13,3%) apresentaram progressão de periodontite.Diabetes não foi associada à progressão de periodontite (p=0,67) e o tabagismo foi significantemente associado a maior progressão de periodontite (RC=2,7; 95% IC: 1,01-7,22). 28 indivíduos (18,66%) apresentaram perda dentária os quais somaram 47 dentes perdidos (1,4%). Os motivos e números de dentes perdidos foram respectivamente: doença periodontal (n=34; 72,3%), cárie (n=3; 6,4%), motivos protéticos (n=9; 19,2%), perfuração radicular (n=1; 2,1%). Molares apresentaram maior mortalidade dental do que não molares e homens 3 vezes mais chances de PD do que mulheres (RC=3,16; 95% IC: 1,28-7,78). Indivíduos com 10% de sítios com PS entre 4 e 6 mm apresentaram 5 vezes mais chances de PD (RC= 5,13; IC 95%: 2,04-12,09). A determinação do risco individual pelo modelo ARP (Avaliação do Risco Periodontal) resultou na classificação dos indivíduos em 02(1,3%) de baixo risco, 83 (55,3%) de moderado risco e 65 (43,4%) de alto risco àrecorrência de periodontite. Conclusões:Os programas de manutenção periodontalem ambiente universitário podem estabilizar a condição periodontal obtida apósterapia ativa e, adicionalmente, controlar e/ou minimizar a ação de variáveispreditoras de risco a progressão da periodontite. Neste estudo, a incidência de PDfoi pequena e restrita a poucos indivíduos. A adoção do modelo ARP contribui para adeterminação do risco individual dos indivíduos,permitindo que os escores de riscosejam comparados ao longo do tempo. Assim, este instrumento pode ser válido paramonitorar particularmente variáveis mutáveis de risco e auxiliar na estratégia,determinação e cooperação nos programas de TMP. Aestabilidade dos tecidosperiodontais, controle de variáveis de risco e redução da PD podem ser metasalcançáveis pelos programas de TMP, refletindo a sua eficiência e propiciandomelhor qualidade de vida para indivíduos periodontalmente susceptíveis.This open prospective cohort study aimed to evaluate the progression of periodontitisand, in addition, the incidence, the reasons and the role of risk predictors on theoccurrence of tooth loss (TL) in individuals inserted in a program of periodontalmaintenance therapy (PMT) in academic environment. Methods: 250 individualsdiagnosed with moderate/advanced chronic periodontitis, that had finishedactiveperiodontal therapy, in the Faculty of Dentistry of the Federal University of MinasGerais, Brazil, were selected. Individuals were submitted to a complete clinicalperiodontal examination (PMT1) and collection of social, demographic and biologicalvariables of interest was performed. The degree of compliance of these individuals,(compliers, irregular compliers and non compliers) according to the adhesion to theTMP program in quarterly recalls (PMT2, PMT3 and PMT4), wasevaluated during 12months period. A total of 150 individuals, that were considered complete compliers(60%), became eligible for this study. In the recall visits, the following data werecollected for all teeth (with exception of third molars): plaque index (PI), bleeding onprobing (BOP), probing depth (PD), clinical attachment level (CAL), suppuration (SU)and furcation involvement (FI). It was identified, according to the biologicalplausibility, which risk predictors could influence the periodontal clinical condition andthe progression of the periodontitis. The effect of variables of interest andconfounding was tested by univariate analysis and multivaried logistic regression, aswell as the reasons and types of teeth that were lost. Results: A considerableimprovement in periodontal clinical parameters was observed in the majority of theindividuals. During the monitoring, 130 individuals (86.7%) showed periodontalstability and 20 individuals (13.3%) presented periodontitis progression. Diabeteswas not associated with periodontitis progression (p=0.67) and, in contrast, smokingwas significantly associated with periodontitis progression (OR=2.7; 95% IC 1.01-7.22). 28 individuals (18.66%) presented TL, resulting in a total of 47 lost teeth(1.4%). The reasons and numbers of tooth loss and numbers were, respectively:periodontal disease (n=34; 72.3%), caries (n=3; 6.4%), prosthetic reasons (n=9;19.2%), root perforation (n=1; 2.1%). Molars presented greater tooth mortality thannon molars and men presented 3 times more odds of TL than women (OR=3.16;95% IC: 1.28-7.78). Additionally, individuals with 10% of sites with PD between 4 and6mm presented 5 times more odds of TL (OR= 5.13; IC 95%: 2.04 12.09). Theperiodontal risk assessment (PRA) resulted in the classification of individuals in 02(1.3%) low risk, 83 (55.3%) moderate risk and 65 (43.4%) of high-risk for recurrenceof periodontitis. Conclusions: The programmes of periodontal maintenance inacademic environment can stabilize the periodontal condition obtained after activetherapy, additionally to control and/or minimize the action of risk predictors on theprogression of periodontitis. In this study, the TL incidence was small and restrictedto few individuals. The adoption of the model PRA contributes to the determination ofrisk of individuals allowing the risk scores are compared over time. So, thisinstrument can be particularly monitoring changeable risk predictors and assisting inthe strategy, determination and compliance in the PMT programs. The stability ofperiodontal sites, the control of risk predictors and the reduction of TL can bepredictable goals for the PMT programs, reflecting its effectiveness and betterimproving quality of life for individuals susceptible to periodontitis

    Prospective study of complier individuals under periodontal maintenance therapy: analysis of clinical periodontal parameters, risk predictors and the progression of periodontitis

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    Made available in DSpace on 2019-09-12T16:56:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2009Fundação de Amparo à Pesquisa do Estado de Minas Gerais (Fapemig)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Lorentz TCM, Cota LOM, Cortelli JR, Vargas AMD, Costa FO. Prospective study of complier individuals under periodontal maintenance therapy: analysis of clinical periodontal parameters, risk predictors and the progression of periodontitis. J Clin Periodontol 2009; 36: 58-67. doi: 10.1111/j.1600-051X.2008.01342.x. This prospective study aimed to evaluate the progression of periodontitis and the influence of risk variables among individuals attending a programme of periodontal maintenance treatment in an academic environment. A total of 150 individuals diagnosed with chronic moderate-advanced periodontitis, and who had finished active periodontal treatment, were incorporated into the periodontal maintenance therapy. Social, demographic and biological variables of interest from subjects were collected at quarterly recalls, over a 12-month period. The effect of variables of interest and confounding on the periodontal status and progression of periodontitis was tested by univariate and multivariate logistic analysis. A total of 130 subjects (86.7%) showed stable periodontal status, whereas 20 subjects (13.3%) presented periodontitis progression. Twenty-eight subjects (18.66%) presented tooth loss that resulted in a total of 47 lost teeth (1.38%). Diabetes was not found to be associated with periodontitis progression (p=0.67). Smoking was significantly associated with a greater progression of periodontitis (OR=2.7, 95% CI 1.01-7.22). Periodontal maintenance programmes in academic environment can stabilize the periodontal condition obtained after active periodontal therapy as well as control the action of risk variables for the progression of periodontitis.[Medeiros Lorentz, Telma Campos; Miranda Cota, Luis Otavio; Duarte Vargas, Andrea Maria; Costa, Fernando Oliveira] Univ Fed Minas Gerais, Dept Periodontol, Sch Dent, BR-31270901 Belo Horizonte, MG, Brazil[Cortelli, Jose Roberto] Universidade de Taubaté (Unitau), Dept Dent, Periodont Res Div, Sao Paulo, Brazi

    Tratamento cirúrgico das dissecções de aorta tipo A utilizando parada cardiocirculatória total com hipotermia profunda Surgical treatment of type A aortic dissections utilizing total cardiocirculatory arrest with deep hypothermia

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    No período de julho de 1986 a julho de 1993, 22 pacientes portadores de dissecção de aorta tipo A foram tratados cirurgicamente utilizando-se parada cardiocirculatória (PCC) total sob hipotermia profunda (18ºC), dos quais 15 apresentavam dissecção aguda e 7 dissecção crônica. Em 14 casos (64%) a aorta ascendente foi reconstruída utilizando-se enxerto reto de Dacron, com troca valvar aórtica em 5 pacientes e ressuspensão valvar aórtica em 2; a reconstrução do arco aórtico foi empregada em 8 casos (36%), nos quais a dissecção se extendia ou se originava no mesmo, havendo necessidade de reimplante dos ramos supra-aórticos em 3 pacientes. O tempo médio do PCC foi de 43 minutos, a mortalidade hospitalar foi de 18%, e a complicação pós-operatória mais freqüente foi a infecção respiratória. Cinco pacientes (22,7%) apresentaram dano neurológico pós-operatório, sendo, em 4 casos, reversível e atribuível a edema cerebral; 1 caso (4,5%) apresentou acidente vascular hemisférico estabelecido. Concluímos que a técnica de PCC sob hipotermia profunda deve ser utilizada sempre no reparo das dissecções de aorta tipo A, independentemente de sua extensão ao arco aórtico, pois oferece uma proteção cerebral segura, permite a inspeção ampla da zona dissecada e do local de rotura da íntima, e evita o trauma produzido pelo clampeamento da aorta acometida.From July 1986 to July 1993, 22 consecutive patients with Type A Aortic Dissecation were surgically treated using total cardiovascular arrest with deep hypothermia (18ºC). Fifteen cases had acute dissecations and 7 were chronic cases. In 14 cases (64%), the ascending aorta was reconstructed using a straight Dacron graft. In 5 of these, the aortic valve was repaired. The aortic arch was reconstructed in 8 cases (36%) and in 3 of these, the arch branches were reimplanted. The average time of the cardiovascular arrest was 43 minutes and the hospital mortality was 18%. The most frequent complication was respiratory infection, 5 patients (22.7%) showed neurologic damage, 4 of them transient and reversible. In summary, the cardiovascular arrest with deep hypothermia technique for the treatment of Type A Aortic Dissection can be used with reasonable mortality and morbility allowing a safe cerebral protection, good exposure of the dissected aorta and prevents damage to the aortic wall by the cross clamping

    Tooth loss in individuals under periodontal maintenance therapy: prospective study

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    Made available in DSpace on 2019-09-12T16:26:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2010This prospective study aimed to evaluate the incidence, the underlying reasons, and the influence of predictors of risk for the occurrence of tooth loss (TL) in a program of Periodontal Maintenance Therapy (PMT). The sample was composed of 150 complier individuals diagnosed with chronic moderate-severe periodontitis who had finished active periodontal treatment and were incorporated in a program of PMT. Social, demographic, behavioral and biological variables were collected at quarterly recalls, over a 12-month period. The effect of predictors of risk of and confounding for the dependent variable TL was tested by univariate and multivariate analysis, as well as the underlying reasons and the types of teeth lost. During the monitoring period, there was a considerable improvement in periodontal clinical parameters, with a stability of periodontal status in the majority of individuals. Twenty-eight subjects (18.66%) had TL, totaling 47 lost teeth (1.4%). The underlying reasons for TL were: periodontal disease (n = 34, 72.3%), caries (n = 3, 6.4%), prosthetic reasons (n = 9, 19.2%), and endodontic reasons (n = 1, 2.1%). Additionally, subjects with 10% of sites with probing depth between 4 and 6 mm were 5 times more likely to present TL (OR = 5.13, 95% CI 2.04-12.09). In this study, the incidence of TL was small and limited to few individuals. Additionally, gender and severity of periodontitis were significantly associated with TL during the monitoring period.[Cortelli, José Roberto] Universidade de Taubaté, BrazilVargas, Andréia Maria Duarte] Universidade Federal de Minas Gerais, BrazilLorentz, Telma Campos Medeiros; Cota, Luís Otávio Miranda; Costa, Fernando Oliveira] Universidade Federal de Minas Gerais, Brazi
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