105,489 research outputs found

    Building multi-layer social knowledge maps with google maps API

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    Google Maps is an intuitive online-map service which changes people's way of navigation on Geo-maps. People can explore the maps in a multi-layer fashion in order to avoid information overloading. This paper reports an innovative approach to extend the "power" of Google Maps to adaptive learning. We have designed and implemented a navigator for multi-layer social knowledge maps, namely ProgressiveZoom, with Google Maps API. In our demonstration, the knowledge maps are built from the Interactive System Design (ISD) course at the School of Information Science, University of Pittsburgh. Students can read the textbooks and reflect their individual and social learning progress in a context of pedagogical hierarchical structure

    A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

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    Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones

    Heavily obscured AGN with SIMBOL-X

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    By comparing an optically selected sample of narrow lines AGN with an X-ray selected sample of AGN we have recently derived an estimate of the intrinsic (i.e. before absorption) 2-10 keV luminosity function (XLF) of Compton Thick AGNs. We will use this XLF to derive the number of Compton Thick AGN that will be found in the SIMBOL-X survey(s).Comment: Talk at the Simbol-X symposium held in Paris, 2-5 December, 2008. 6 pages, 1 figure with three panel

    Highly bioactive silver and silver/titania composite films grown by chemical vapour deposition

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    This paper describes how photocatalytically active films of TiO2, grown by thermal CVD, may be functionally and structurally modified by deposition of nano-structured silver via a novel flame assisted CVD process. The resulting composite films are shown to be highly durable, highly photocatalytically active and are also shown to possess strong antibacterial behaviour. The deposition control, arising from the described approach, offers the potential to control the film nanostructure, which is proposed to be crucial in determining the photo and bio-activity of the combined film structure, and the transparency of the composite films. Furthermore, we show that the resultant films also exhibit “self-regeneration” capability, in that they both kill bacteria present on the film surface and then photo-degrade the residues. Such a dual action significantly reducing the problems of surface deactivation due to build up of contamination. These properties are especially significant when combined with the well-known durability of CVD deposited thin films, offering new opportunities for enhanced application in areas where bioactive surface functionality is sought

    The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions

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    C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit immunostaining in benign nevi and in primary and metastatic malignant melanomas, to determine whether c-Kit can aid in the differential diagnosis of these lesions. c-Kit immunostaining was per- formed in 60 cases of pigmented lesions, including 39 benign nevi (5 blue nevi, 5 intra- dermal nevi, 3 junctional nevi, 15 cases of pri- mary compound nevus, 11 cases of Spitz nevus), 18 cases of primary malignant melanoma and 3 cases of metastatic melanoma. The vast majority of nevi and melanomas examined in this study were posi- tive for c-Kit, with minimal differences between benign and malignant lesions. C-Kit cytoplasmatic immunoreactivity in the intraepidermal proliferating nevus cells, was detected in benign pigmented lesions as well as in malignant melanoma, increasing with the age of patients (P=0.007) in both groups. The patient’s age at presentation appeared to be the variable able to cluster benign and malignant pigmented lesions. The percentage of c-Kit positive intraepidermal nevus cells was better associated with age despite other vari- ables (P=0.014). The intensity and percentage of c-Kit positivity in the proliferating nevus cells in the dermis was significantly increased in malignant melanocytic lesions (P=0.015 and P=0.008) compared to benign lesions (compound melanocytic nevi, Spitz nevi, intradermal nevi, blue nevi). Immunostaning for c-Kit in metastatic melanomas was nega- tive. Interestingly in two cases of melanoma occurring on a pre-existent nevus, the melanoma tumor cells showed strong cytoplas- matic and membranous positivity for c-kit, in contrast with the absence of any immunoreac- tivity in pre-existent intradermal nevus cells. C-Kit does not appear to be a strong immuno- histochemical marker for distinguishing melanoma from melanocytic nevi, if we consid- er c-Kit expression in intraepidermal prolifer- ating cells. The c-Kit expression in proliferat- ing melanocytes in the dermis could help in the differential diagnosis between a superfi- cial spreading melanoma (with dermis inva- sion) and a compound nevus or an intradermal nevus. Finally, c-Kit could be a good diagnostic tool for distinguishing benign compound nevi from malignant melanocytic lesions with der- mis invasion and to differentiate metastatic melanoma from primary melanoma
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