Žvynelinė ir uždegiminės odos ligos 2020

The aim of this virtual conference is to share and increase dermatovenereology specialists’ knowledge about chronic inflammatory dermatoses. Attendees will be able to listen to latest scientific updates not only on psoriasis, but atopic dermatitis, hidradenitis suppurativa, acne, rosacea and other diseases as well. Experienced lecturers from Lithuania and other countries will present their research works, reviews and rare clinical cases, which are both of theoretical and practical benefit.Šios nuotolinės konferencijos tikslas yra pasidalinti ir pagerinti dermatovenerologijos specialistų žinias apie lėtines uždegimines odos ligas. Konferencijos dalyviams bus suteikta galimybė išgirsti naujausią mokslinę informaciją ne tik apie žvynelinę, tačiau ir apie atopinį dermatitą, pūlingą hidradenitą, aknę, rožinę bei kitas ligas. Patyrę Lietuvos ir užsienio lektoriai pristatys savo tyrimus, apžvalgas ir klinikinius atvejus, kurie naudingi tiek teorinių, tiek praktinių žinių gilinimui

Management of a primary malignant melanoma of uterine cervix stage IVA patient with radical surgery and adjuvant oncolytic virus Rigvir(R) therapy: A case report.

Primary malignant melanoma of the uterine cervix is a rare disease with poor prognosis and high recurrence rate. We used Rigvir® as adjuvant therapy for a stage IVA patient. Tolerability, overall and progression-free survival are good

Inksto rezekcija gali būti sėkmingas inksto epitelioidinės angiomiolipomos gydymo būdas: atvejo pristatymas ir literatūros apžvalga

Background. Renal epithelioid angiomyolipoma is a rare tumour which involves kidneys in most cases. It is known for its aggressive behaviour as a significant number of cases have been associated with metastatic epithelioid angiomyolipoma. Usually, radical treatment with systemic therapy is recommended. Only a small number of cases of epithelioid angiomyolipomas have been reported with the standard treatment being radical or partial nephrectomy. We present a case report showing that partial nephrectomy can be a successful treatment option for renal epithelioid angiomyolipoma. This is the first case of this nature in Lithuania. Case presentation. In this case, a 40-year-old male with epithelioid angiomyolipoma of the left kidney is presented. In 2012, a cystic left renal mass 40 × 41 mm in size was diagnosed incidentally while performing ultrasound and later confirmed by MRI. Due to the size of the tumour and the possibility of renal cell carcinoma, surgery was scheduled. Left partial nephrectomy was performed successfully. Final pathology report came back with the diagnosis of renal epithelioid angiomyolipoma. The patient had yearly follow-up for six years by CT scan, and neither recurrence nor progression were observed. Conclusion. Early detection and diagnosis are crucial for treatment as the tumour tends to have malignancy potential. With early diagnosis, partial nephrectomy can be performed with yearly follow-up and no systemic treatment required

Commentary: Primary cardiac lymphoma: Two cases and a review of literature

Primary cardiac lymphoma (PCL) is a rare malignant potentially lethal disease, which only involves the heart. PCL is diagnosed only in 1.3 % of heart tumor patients. PCL belongs to the non-Hodgkin extranodal lymphomas group and comprise 0.5 % of them. To date about 200 cases are published and the most comprehensive review, which includes 197 cases, is written by Petrich et al. The most common histological type of PCL is diffuse large B cell lymphoma1–3. In our article entitled “Primary cardiac lymphoma: Two cases and a review of literature”, we have described two patients that were treated at our center4. Both of the patients were diagnosed with PCL. Both cases were confirmed histologically to be diffuse large B-cell lymphoma

Common bile duct villous adenoma: a case report and review of the literature

Background: According to the literature, benign bile duct tumors are exceedingly uncommon. To the best of our knowledge, we report the largest extrahepatic bile duct villous adenoma described in the literature. Case presentation: We present a case of a 77-year-old Caucasian woman with obstructive jaundice. Laboratory tests revealed that she had elevated bilirubin and liver enzyme levels. A computed tomographic scan showed a homogeneous 5 × 3–cm mass obstructing the common bile duct. The results of brush cytology were consistent with a bile duct villous papilloma. However, on the basis of the tumor’s radiological features, a preliminary diagnosis of extrahepatic bile duct malignant tumor was made. After discussion among the multidisciplinary team, a surgical resection of the bile duct tumor was performed. Histopathological examination confirmed a villous adenoma. The patient’s postoperative course was uneventful. Conclusions: In patients with bulky extrahepatic bile duct tumors, surgical resection alone may be safe and curative

Primary cardiac lymphoma: two cases and a review of literature

Background: Primary cardiac lymphoma is one of the rarest tumours of the heart. It belongs to the extra-nodal non-Hodgkin’s lymphomas. The most common type of this tumour is diffuse large B cell lymphoma. Usually, right atrium and right ventricle are involved. This tumour is fatal unless diagnosed and treated in time. In this article two female patients who were diagnosed with primary cardiac lymphoma and treated at our clinic are described. The first patient went to remission after the treatment, while the second patient died. The goals of this article are to show the difficulties of diagnosing and treating this disease, the role of cardiac surgery in its treatment and to raise awareness of this disease. Case reports: In this article two female patients who were diagnosed with primary cardiac lymphoma and treated at our clinic are described. The first patient went to remission after the treatment, while the second patient died. Conclusions: Primary cardiac lymphoma is a very rare disease. At the moment the most effective treatment is chemotherapy. Palliative surgery may be necessary to correct hemodynamics when venous blood flow to the lungs is disturbed

A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue

Misclassification rate of 5-7 % was achieved, compared to that of 11-18 % for the VE-median-based prediction. Conclusions Our experiments provide methodology to achieve accurate Ki67-LI estimation by DIA, based on proper validation, calibration, and measurement error correction procedures, guided by quantified bias from reference values obtained by stereology grid count. This basic validation step is an important prerequisite for high-throughput automated DIA applications to investigate tissue heterogeneity and clinical utility aspects of Ki67 and other immunohistochemistry (IHC) biomarkers