Quantum Walker in Presence of a Moving Detector

In this work, we study the effect of a moving detector on a discrete time one dimensional Quantum Random Walk where the movement is realized in the form of hopping/shifts. The occupation probability $f(x,t;n,s)$ is estimated as the number of detection $n$ and amount of shift $s$ vary. It is seen that the occupation probability at the initial position $x_D$ of the detector is enhanced when $n$ is small which is a quantum mechanical effect but decreases when $n$ is large. The ratio of occupation probabilities of our walk to that of an Infinite walk shows a scaling behavior of $\frac{x_D^2}{n^2}$. It shows a definite scaling behavior with amount of shifts $s$ also. The limiting behaviors of the walk are observed when $x_D$ is large, $n$ is large and $s$ is large and the walker for these cases approach the Infinite Walk, The Semi Infinite Walk and the Quenched Quantum Walk respectively.Comment: 11 pages, 10 figures, revtex4-

Secure Transaction Model for NoSQL Database Systems: Review

NoSQL cloud database frameworks would consist new sorts of databases that would construct over many cloud hubs and would be skilled about storing and transforming enormous information. NoSQL frameworks need to be progressively utilized within substantial scale provisions that require helter skelter accessibility. What’s more effectiveness for weaker consistency? Consequently, such frameworks need help for standard transactions which give acceptable and stronger consistency. This task proposes another multi-key transactional model which gives NoSQL frameworks standard for transaction backing and stronger level from claiming information consistency. Those methodology is to supplement present NoSQL structural engineering with an additional layer that manages transactions. The recommended model may be configurable the place consistency, accessibility Furthermore effectiveness might make balanced In view of requisition prerequisites. The recommended model may be approved through a model framework utilizing MongoDB. Preliminary examinations show that it ensures stronger consistency Furthermore supports great execution

ynthetic berberine derivatives as potential new drugs

The modern process of new drug discovery and development is an exciting, yet a challenging, endeavor. Although it can result in significant financial income and meet the medical needs of patients, it ultimately may result in failure. To achieve a fast and successful new product discovery and development process, natural products which are evolutionarily optimized as drug-like molecules have gained great attention as better potential sources of new chemical entities. Historically, plant species containing berberine are used in various traditional phytotherapy. However, despite the various therapeutic effects it exerts, berberine is not yet developed into a drug product. Addressing the barriers that hinder its successful development and the efforts made to overcome them is thus crucial. The toxicological and pharmacokinetic properties of berberine are the main barriers towards its development into a marketed drug product. It has low aqueous solubility, poor absorption, fast metabolism, and wide tissue distribution which lead to low bioavailability limiting its clinical application. Synthetic berberine derivatives with improved properties are suggested as better alternatives for further development and future therapeutic application. Hence, this paper summarizes the preclinical research studies conducted in the last decade to reveal the therapeutic potential of synthetic berberine derivatives for the treatment of various diseases and hence achieve successful berberine-based drug development in the future. To exploit the value of natural products as a source of leads for the development of effective drugs, collaboration among the different discovery and development scientists is essential

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Hydrogels evolved as an outstanding carrier material for local and controlled drug delivery that tend to overcome the shortcomings of old conventional dosage forms for small drugs (NSAIDS) and large peptides and proteins. The aqueous swellable and crosslinked polymeric network structure of hydrogels is composed of various natural, synthetic and semisynthetic biodegradable polymers. Hydrogels have remarkable properties of functionality, reversibility, sterilizability, and biocompatibility. All these dynamic properties of hydrogels have increased the interest in their use as a carrier for peptides and proteins to be released slowly in a sustained manner. Peptide and proteins are remarkable therapeutic agents in today’s world that allow the treatment of severe, chronic and life-threatening diseases, such as diabetes, rheumatoid arthritis, hepatitis. Despite few limitations, hydrogels provide fine tuning of proteins and peptides delivery with enormous impact in clinical medicine. Novels drug delivery systems composed of smart peptides and molecules have the ability to drive self-assembly and form hydrogels at physiological pH. These hydrogels are significantly important for biological and medical fields. The primary objective of this article is to review current issues concerned with the therapeutic peptides and proteins and impact of remarkable properties of hydrogels on these therapeutic agents. Different routes for pharmaceutical peptides and proteins and superiority over other drugs candidates are presented. Recent advances based on various approaches like self-assembly of peptides and small molecules to form novel hydrogels are also discussed. The article will also review the literature concerning the classification of hydrogels on a different basis, polymers used, “release mechanisms” their physical and chemical characteristics and diverse applications

Mesoporous silica nanomaterials: versatile nanocarriers for cancer theranostics and drug and gene delivery

Mesoporous silica nanomaterials (MSNs) have made remarkable achievements and are being thought of by researchers as materials that can be used to effect great change in cancer therapies, gene delivery, and drug delivery because of their optically transparent properties, flexible size, functional surface, low toxicity profile, and very good drug loading competence. Mesoporous silica nanoparticles (MSNPs) show a very high loading capacity for therapeutic agents. It is well known that cancer is one of the most severe known medical conditions, characterized by cells that grow and spread rapidly. Thus, curtailing cancer is one of the greatest current challenges for scientists. Nanotechnology is an evolving field of study, encompassing medicine, engineering, and science, and it has evolved over the years with respect to cancer therapy. This review outlines the applications of mesoporous nanomaterials in the field of cancer theranostics, as well as drug and gene delivery. MSNs employed as therapeutic agents, as well as their importance and future prospects in the ensuing generation of cancer theranostics and drug and therapeutic gene delivery, are discussed herein. Thus, the use of mesoporous silica nanomaterials can be seen as using one stone to kill three birds