The Worst Horror of All: Greene’s Political and Salvific Imagination in Brighton Rock

An evaluation of Graham Greene\u27s Brighton Rock as it apprehends the Catholic novel as form. With ample assistance from Graham Greene\u27s The Power and the Glory, Robert Hugh Benson\u27s The Lord of the World, and select works of Fredric Jameson—most notably The Political Unconscious—this analysis seeks to clarify the politico-spiritual horizon evident in Greene\u27s first Catholic novel. By reviewing the novel through the lens of both Catholic theology and modern historical dialectic material criticism, this evaluation reclaims Graham Greene\u27s early political radicalism that critics identify better in his later, less-religious texts. Discovered most clearly in the ending of Brighton Rock, this paper reshapes the text\u27s conclusion from a solution offered to society via narrative to a location. Once this spatial aspect of the novel\u27s ending has been established, one can recognize the potential within lived Catholic experience to synthesize with a concordant working-class consciousness

A Technique For The Evaluation Of Double Excitation Of Atoms By Fast Protons And Antiprotons

A technique for evaluating cross sections for two-electron excitation in collisions of atoms with fast particles of charge ZP is presented. The atomic wave function is approximated by a sum of pair products of one-electron wave functions, with the coefficients chosen by diagonalizing the fully correlated twoelectron Hamiltonian. Thus spatial correlation is included in both the asymptotic and scattering regions by using these configuration-interaction (Cl) wave functions for initial, intermediate, and final states. Use of CI wave function also allows the first-order contributions to be expressed in closed, analytical form. Both the energy-conserving and energy-nonconserving parts of the second-order amplitude are evaluated. The former (a correlated generalization of the independent-electron approximation) is analytical and the latter is a one-dimensional integral. In helium it is found that the double-excitation cross sections are sensitive to the sign of the projectile charge, but that the energy region where this sensitivity is of the same order as for double ionization is 0.1 to 0.5 Me V /amu, whereas the latter has peak charge sensitivity at 1.5 MeV /amu. Comparison is made with some experimental results

High-velocity Limits for the Ratio of Double to Single Ionisation of Helium by Projectiles with Electrons

The ratio of total double to total single ionisation cross sections, R, by high velocity projectiles containing electrons is examined in the first Born approximation. For ionisation of helium by H+, H0 and He0 impact, it is found that t filt H+ \u3c filt Ho \u3c filt Heo . Connection with Bohr\u27s free-collision model for collisions with projectile electrons is given

Recoil Distributions in Particle Transfer

Classical Thomas peaks in various fast second-order particle transfer processes are quantum mechanically broadened by energy nonconservation in the intermediate states of collision. This quantum broadening is considered in observable velocity distributions of recoil particles

Neural correlates of executive function and working memory in the 'at risk mental state'

Background and Aims: People with ‘prodromal’ symptoms have a very high risk of developing psychosis. We used functional MRI to examine the neurocognitive basis of this vulnerability. Method: Cross-sectional comparison of subjects with an ARMS (n=17), first episode schizophreniform psychosis (n=10) and healthy volunteers (n=15). Subjects were studied using functional MRI while they performed an overt verbal fluency task, a random movement generation paradigm and an N-Back working memory task. Results: During an N-Back task the ARMS group engaged inferior frontal and posterior parietal cortex less than controls but more than the first episode group. During a motor generation task, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than the first episode group. During verbal fluency using ‘Easy’ letters, the ARMS group demonstrated intermediate activation in the left inferior frontal cortex, with first episode groups showing least, and controls most, activation. When processing ‘Hard’ letters, differential activation was evident in two left inferior frontal regions. In its dorsolateral portion, the ARMS group showed less activation than controls but more than the first episode group, while in the opercular part of the left inferior frontal gyrus / anterior insula activation was greatest in the first episode group, weakest in controls and intermediate in the ARMS group. Conclusions: The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have just developed psychosis but less severe

Microbes, histology, blood analysis, enterotoxins, and cytokines: Findings from the ASERF Systemic Symptoms in Women-Biospecimen Analysis Study: Part 3

BACKGROUND: There has been an increasing need to acquire rigorous scientific data to answer the concerns of physicians, patients, and the FDA regarding the self-reported illness identified as breast implant illness (BII). There are no diagnostic tests or specific laboratory values to explain the reported systemic symptoms described by these patients. OBJECTIVES: The aim of this study was to determine if there are quantifiable laboratory findings that can be identified in blood, capsule tissue pathology, or microbes that differentiate women with systemic symptoms they attribute to their implants from 2 control groups. METHODS: A prospective blinded study enrolled 150 subjects into 3 cohorts: (A) women with systemic symptoms they attribute to implants who requested implant removal; (B) women with breast implants requesting removal or exchange who did not have symptoms attributed to implants; and (C) women undergoing cosmetic mastopexy who have never had any implanted medical device. Capsule tissue underwent detailed analysis and blood was sent from all 3 cohorts to evaluate for markers of inflammation. RESULTS: No significant histologic differences were identified between the cohorts, except there were more capsules with synovial metaplasia in the non-BII cohort. There was no statistical difference in thyroid-stimulating hormone, vitamin D levels, or complete blood count with differential between the cohorts. Next-generation sequencing revealed no statistically significant difference in positivity between Cohort A and B. Of the 12 cytokines measured, 3 cytokines, interleukin (IL)-17A, IL-13, and IL-22, were found to be significantly more often elevated in sera of subjects in Cohort A than in Cohorts B or C. The enterotoxin data demonstrated an elevation in immunoglobulin G (IgG) anti-Staphylococcus aureus enterotoxin A in Cohort A. There was no correlation between the presence of IgE or IgG anti-Staphylococcal antibody and a positive next-generation sequencing result. CONCLUSIONS: This study adds to the current literature by demonstrating few identifiable biomedical markers to explain the systemic symptoms self-reported by patients with BII

Ketamine-Induced Disruption of Verbal Self-Monitoring Linked to Superior Temporal Activation

Introduction: Misattribution of distorted self-generated speech in patients with schizophrenia has been associated with increased lateral temporal activation. As a pharmacological model of schizophrenia, we tested whether ketamine would induce the same effects in healthy individuals. Methods: Participants were 8 healthy male volunteers who were nave to ketamine (mean age: 28 years). Ketamine (0.23 mg/kg bolus followed by 0.64 mg/kg/h) and placebo infusions were administered in a double-blind, randomised order, during 2 functional magnetic resonance imaging (fMRI) sessions. Each fMRI session consisted of a verbal self-monitoring task in which auditory feedback was experimentally modified. Results: Ketamine was associated with psychotic and dissociative symptoms. Participants made more misattributions of distorted self-generated speech (p <0.02) during the ketamine infusion. Ketamine led to reduced activation in the left superior temporal cortex during self-distorted speech, regardless of whether the speech was identified correctly or not, as compared to the placebo infusion. Misidentification of speech that had been distorted was not associated with any increase in brain activation in during the placebo infusion, however ketamine-induced misattributions were associated with a relative increase in left superior temporal cortex activation. Discussion: These data are consistent with the notion that self-monitoring impairments underlie psychotic symptoms and suggest that N-methyl-D-aspartate (NMDA) receptor dysfunction may mediate self-monitoring deficits and psychotic phenomena in schizophrenia

Ketamine-Induced Disruption of Verbal Self-Monitoring Linked to Superior Temporal Activation

Introduction: Misattribution of distorted self-generated speech in patients with schizophrenia has been associated with increased lateral temporal activation. As a pharmacological model of schizophrenia, we tested whether ketamine would induce the same effects in healthy individuals. Methods: Participants were 8 healthy male volunteers who were nave to ketamine (mean age: 28 years). Ketamine (0.23 mg/kg bolus followed by 0.64 mg/kg/h) and placebo infusions were administered in a double-blind, randomised order, during 2 functional magnetic resonance imaging (fMRI) sessions. Each fMRI session consisted of a verbal self-monitoring task in which auditory feedback was experimentally modified. Results: Ketamine was associated with psychotic and dissociative symptoms. Participants made more misattributions of distorted self-generated speech (p <0.02) during the ketamine infusion. Ketamine led to reduced activation in the left superior temporal cortex during self-distorted speech, regardless of whether the speech was identified correctly or not, as compared to the placebo infusion. Misidentification of speech that had been distorted was not associated with any increase in brain activation in during the placebo infusion, however ketamine-induced misattributions were associated with a relative increase in left superior temporal cortex activation. Discussion: These data are consistent with the notion that self-monitoring impairments underlie psychotic symptoms and suggest that N-methyl-D-aspartate (NMDA) receptor dysfunction may mediate self-monitoring deficits and psychotic phenomena in schizophrenia

An exploration of function analysis and function allocation in the commercial flight domain

The applicability is explored of functional analysis methods to support cockpit design. Specifically, alternative techniques are studied for ensuring an effective division of responsibility between the flight crew and automation. A functional decomposition is performed of the commercial flight domain to provide the information necessary to support allocation decisions and demonstrate methodology for allocating functions to flight crew or to automation. The function analysis employed 'bottom up' and 'top down' analyses and demonstrated the comparability of identified functions, using the 'lift off' segment of the 'take off' phase as a test case. The normal flight mission and selected contingencies were addressed. Two alternative methods for using the functional description in the allocation of functions between man and machine were investigated. The two methods were compared in order to ascertain their relative strengths and weaknesses. Finally, conclusions were drawn regarding the practical utility of function analysis methods