Testing the circularity of PSR B0818-41's carousel

The phenomenon of sub-pulse drifting is an important single-pulse phenomenon that can potentially provide important insights into the elusive radio emission mechanism in pulsars. We analyze the frequency behaviour of the single pulses of B0818-41, observed from 300 to 500 MHz (Band 3 of the uGMRT), and compare it to the evolution of the average profile to place constraints on the geometry of the pulsar's emission beam. We show that a circular carousel of discrete beamlets, where each beamlet has radial symmetry, is not consistent with the observed behaviour, and describe an alternative, consistent range of possible elliptical carousel geometries. We also combine the uGMRT data with some archival MWA observations and several other published profiles to characterize the profile evolution across a frequency range spanning ~170 MHz to ~1.4 GHz

PSR J0026-1955: A curious case of evolutionary subpulse drifting and nulling

PSR J0026-1955 was independently discovered by the Murchison Widefield Array (MWA) recently. The pulsar exhibits subpulse drifting, where the radio emission from a pulsar appears to drift in spin phase within the main pulse profile, and nulling, where the emission ceases briefly. The pulsar showcases a curious case of drift rate evolution as it exhibits rapid changes between the drift modes and a gradual evolution in the drift rate within a mode. Here we report new analysis and results from observations of J0026-1955 made with the upgraded Giant Meterwave Radio Telescope (uGMRT) at 300-500 MHz. We identify two distinct subpulse drifting modes: A and B, with mode A sub-categorised into A0, A1, and A2, depending upon the drift rate evolutionary behaviour. Additionally, the pulsar exhibits short and long nulls, with an estimated overall nulling fraction of ~58%, which is lower than the previously reported value. Our results also provide evidence of subpulse memory across nulls and a consistent behaviour where mode A2 is often followed by a null. We investigate the drift rate modulations of J0026-1955 and put forward two different models to explain the observed drifting behaviour. We suggest that either a change in polar gap screening or a slow relaxation in the spark configuration could possibly drive the evolution in drift rates. J0026-1955 belongs to a rare subset of pulsars which exhibit subpulse drifting, nulling, mode changing, and drift rate evolution. It is, therefore, an ideal test bed for carousel models and to uncover the intricacies of pulsar emission physics.Comment: 14 pages, 10 figures, 1 table. Accepted for publication in MNRA

Single-pulse analysis and average emission characteristics of PSR J1820-0427 from observations made with the MWA and uGMRT

We have studied the pulse-to-pulse variability in PSR J1820--0427 and its frequency dependence using high-quality, wide-band observations made from the upgraded Giant Metrewave Radio Telescope (uGMRT; 300-750 MHz) and the Murchison Widefield Array ($\sim$170-200 MHz). The low-frequency data reveal a previously unreported feature in the average profile (at 185 MHz) after accounting for the effects of temporal broadening arising from multi-path scattering due to the Interstellar Medium (ISM). We advance a new method for flux density calibration of beamformed data from the uGMRT and use it to measure the single pulse flux densities across the uGMRT band. Combined with previously published measurements, these flux densities are best fit with a power-law spectrum with a low-frequency turnover. We also use calibrated flux densities to explore the relationship between pulse-to-pulse variability and the spectral index of individual pulses. Our analysis reveals a large scatter in the single-pulse spectral indices and a general tendency for brighter pulses to show a steepening of the spectral index. We also examine the frequency-dependence of the pulse-fluence distribution and its relation to the Stochastic Growth Theory.Comment: 13 pages, 9 figures, 2 tables. Accepted for publication in MNRA

Enhanced 'In-situ' catalysis via microwave selective heating: catalytic chain transfer polymerisation

An extremely facile, single stage, ‘in-situ’, Catalytic Chain Transfer Polymerisation (CCTP) process has been identified, where the optimal polymerisation process was shown to depend upon a combination of catalyst characteristics (i.e. solubility, sensitivity, activity) and the method of heating applied. In comparison to the current benchmark catalyst, the preparation of which is only about 40 % efficient, this represents a significant increase in waste prevention/atom efficiency and removes the need for organic solvent. It was also shown possible to significantly reduce the overall ‘in-situ’ reaction cycle time by adopting different processing strategies in order to minimise energy use. The application of microwave heating was demonstrated to overcome system diffusion/dilution issues and result in rapid, ‘in-situ’ catalyst formation. This allowed processing times to be minimised by enabling a critical concentration of the species susceptible to microwave selective heating to dominate the heat and mass transfer involved

Independent discovery of a nulling pulsar with unusual subpulse drifting properties with the Murchison Widefield Array

We report the independent discovery of PSR J0026-1955 with the Murchison Widefield Array (MWA) in the ongoing Southern-sky MWA Rapid Two-metre pulsar survey. J0026-1955 has a period of ∼1.306 s, a dispersion measure of ∼20.869 pc cm-3, and a nulling fraction of ∼77%. This pulsar highlights the advantages of the survey's long dwell times (∼80 minutes), which, when fully searched, will be sensitive to the expected population of similarly bright, intermittent pulsars with long nulls. A single-pulse analysis in the MWA's 140-170 MHz band also reveals a complex subpulse drifting behavior, including both rapid changes of the drift rate characteristic of mode switching pulsars, as well as a slow, consistent evolution of the drift rate within modes. In some longer drift sequences, interruptions in the otherwise smooth drift rate evolution occur preferentially at a particular phase, typically lasting a few pulses. These properties make this pulsar an ideal test bed for prevailing models of drifting behavior such as the carousel model

“A very orderly retreat”: Democratic transition in East Germany, 1989-90

East Germany's 1989-90 democratisation is among the best known of East European transitions, but does not lend itself to comparative analysis, due to the singular way in which political reform and democratic consolidation were subsumed by Germany's unification process. Yet aspects of East Germany's democratisation have proved amenable to comparative approaches. This article reviews the comparative literature that refers to East Germany, and finds a schism between those who designate East Germany's transition “regime collapse” and others who contend that it exemplifies “transition through extrication”. It inquires into the merits of each position and finds in favour of the latter. Drawing on primary and secondary literature, as well as archival and interview sources, it portrays a communist elite that was, to a large extent, prepared to adapt to changing circumstances and capable of learning from “reference states” such as Poland. Although East Germany was the Soviet state in which the positions of existing elites were most threatened by democratic transition, here too a surprising number succeeded in maintaining their position while filing across the bridge to market society. A concluding section outlines the alchemy through which their bureaucratic power was transmuted into property and influence in the “new Germany”

Stable nebulization and muco‐trapping properties of regdanvimab/IN‐006 support its development as a potent, dose‐saving inhaled therapy for COVID‐19

Abstract The respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID‐19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral dosing necessitates very large doses and places a substantial burden on the healthcare system. In contrast, direct inhaled delivery of mAb therapeutics offers the convenience of self‐dosing at home, as well as much more efficient mAb delivery to the respiratory tract. Here, building on our previous discovery of Fc‐mucin interactions crosslinking viruses to mucins, we showed that regdanvimab, a potent neutralizing mAb already approved for COVID‐19 in several countries, can effectively trap SARS‐CoV‐2 virus‐like particles in fresh human airway mucus. IN‐006, a reformulation of regdanvimab, was stably nebulized across a wide range of concentrations, with no loss of activity and no formation of aggregates. Finally, nebulized delivery of IN‐006 resulted in 100‐fold greater mAb levels in the lungs of rats compared to serum, in marked contrast to intravenously dosed mAbs. These results not only support our current efforts to evaluate the safety and efficacy of IN‐006 in clinical trials, but more broadly substantiate nebulized delivery of human antiviral mAbs as a new paradigm in treating SARS‐CoV‐2 and other respiratory pathologies

The Southern-sky MWA Rapid Two-metre (SMART) pulsar survey - I. : survey design and processing pipeline

We present an overview of the Southern-sky MWA Rapid Two-metre (SMART) pulsar survey that exploits the Murchison Widefield Array's large field of view and voltage-capture system to survey the sky south of 30 in declination for pulsars and fast transients in the 140-170 MHz band. The survey is enabled by the advent of the Phase II MWA's compact configuration, which offers an enormous efficiency in beam-forming and processing costs, thereby making an all-sky survey of this magnitude tractable with the MWA. Even with the long dwell times employed for the survey (4800 s), data collection can be completed in <![CDATA[ $100 h of telescope time, while still retaining the ability to reach a limiting sensitivity of 2-3 mJy (at 150 MHz, near zenith), which is effectively 3-5 times deeper than the previous-generation low-frequency southern-sky pulsar survey, completed in the 1990s. Each observation is processed to generate 5000-8000 tied-array beams that tessellate the full field of view (at 155 MHz), which are then processed to search for pulsars. The voltage-capture recording of the survey also allows a multitude of post hoc processing options including the reprocessing of data for higher time resolution and even exploring image-based techniques for pulsar candidate identification. Due to the substantial computational cost in pulsar searches at low frequencies, the survey data processing is undertaken in multiple passes: in the first pass, a shallow survey is performed, where 10 min of each observation is processed, reaching about one-third of the full-search sensitivity. Here we present the system overview including details of ongoing processing and initial results. Further details including first pulsar discoveries and a census of low-frequency detections are presented in a companion paper. Future plans include deeper searches to reach the full sensitivity and acceleration searches to target binary and millisecond pulsars. Our simulation analysis forecasts 300 new pulsars upon the completion of full processing. The SMART survey will also generate a complete digital record of the low-frequency sky, which will serve as a valuable reference for future pulsar searches planned with the low-frequency Square Kilometre Array