Liposomes encapsulating polymeric chitosan based vesicles - a vesicle in vesicle system for drug delivery

Drug delivery systems comprising vesicles prepared from one amphiphile encapsulating vesicles prepared from a second amphiphile have not been prepared previously due to a tendency of the bilayer components of the different vesicles to mix during preparation. Recently we have developed polymeric vesicles using the new polymer-palmitoyl glycol chitosan and cholesterol in a 2:1 weight ratio. These polymeric vesicles have now been encapsulated within egg phosphatidylcholine (egg PC), cholesterol (2:1 weight ratio) liposomes yielding a vesicle in vesicle system. The vesicle in vesicle system was visualised by freeze fracture electron microscopy. The mixing of the different bilayer components was studied by monitoring the excimer fluorescence of pyrene-labelled polymeric vesicles after their encapsulation within egg PC liposomes or hexadecyl diglycerol ether niosomes. A minimum degree of lipid mixing was observed with the polymeric vesicle-egg PC liposome system when compared to the polymeric vesicle-hexadecyl diglycerol ether niosome system. The polymeric vesicle-egg PC vesicle in vesicle system was shown to retard the release of encapsulated solutes. 28% of 5(6)-carboxyfluorescein (CF) encapsulated in the polymeric vesicle compartment of the vesicle in vesicle system was released after 4 h compared to the release of 62% of encapsulated CF from plain polymeric vesicles within the same time period

The Constitutionality of Restrictions on Recreational Cannabis Advertising: Balancing Public Health and Freedom of Expression

On April 20, 2016, Health Minister Jane Philpott announced that legislation legalizing recreational marijuana would be introduced in Spring 2017, with the goal of keeping marijuana out of the hands of children and profit out of the hands of criminals. Bill C-45, An Act Respecting Cannabis passed the second reading in the House of Commons, and contains restrictions on advertising cannabis, with a few exceptions. Advertising is recognized as a protected form of expression under the Charter of Rights and Freedoms, so if the government infringes on this right, they must be able to prove that it is justified in a free and democratic society, pursuant to section 1 of the Charter. The Supreme Court of Canada has twice assessed restrictions on tobacco advertising, providing a framework for assessing whether advertising restrictions pass constitutional muster. Using this framework, this thesis analyzes whether the proposed restrictions on advertising marijuana are constitutional

Religious Heterogamy and the Intergenerational Transmission of Religion in China

Research has long demonstrated that parents who do not share the same religious tradition produce less religious children than parents who do. Therefore, religious heterogamy has been associated with the generational decline of religion in Western societies. How about China, where religion has been resurging in the last few decades? Existing studies suggest two opposing possibilities, the restrictive and repressive national context may diminish parental impact on religious socialization, or the family of religious minorities withstands contextual pressures. Using the 2007 Spiritual Life Survey of Chinese Residents, we applied logistic regression modeling to examine patterns of association between having one or two religious parents during childhood and current religious affiliation, beliefs, behavior, and salience of the respondents in China. Analyses reveal that despite China’s atheist education system and strict religion policies, having at least one religiously affiliated parent is associated with increased religiosity compared to having two nonreligious parents. As the number of interreligious marriages rises in Chinese society, religious heterogamy contributes to the growth of religion among younger generations. Whereas religious heterogamy in the West has a secularizing effect on the next generation and contributes to religion’s decline, religious heterogamy in secular nations such as China has a religionizing effect and contributes to religion’s rise

Exercise is delayed in critically ill patients: a five year observational study in an Australian tertiary intensive care unit

Duration of bed rest among critically ill patients in ICU has been associated with development of persistent weakness that can last for more than five years. Commencing early exercise interventions in ICU is likely to reduce critically ill patients’ physical dysfunction. However, critically ill patients often experience prolonged periods of bed rest and inactivity. This study examined the timing of commencement of exercise interventions, including sitting out of bed and upright mobilisation, following physiological stability in critically ill patients and describes key clinical outcomes. Participants included consecutive patients admitted for >48 hours to a 25-bed Australian mixed medical and surgical adult ICU between July 2009 and June 2014. Time taken for patients to achieve neurological, cardiorespiratory and cardiovascular (physiological) stability was calculated and timing of initial sitting out of bed and upright mobilisation was recorded. A small number of patients (n=206, 6.0%) did not achieve physiological stability. A substantial proportion of patients (n=1377, 40.1%) did not complete any mobilisation or sitting activities. For patients (n=1851, 53.9%) who did undertake mobilisation or sitting activities, activity commenced a median (IQR) of 3.6 (2.0, 7.7) days after ICU admission. This represented a median (IQR) delay after physiological stability of 2.3 (1.3, 4.4) days for mobilisation and 2.7 (1.5, 5.7) days for sitting. In-hospital mortality was 14.3% (n=491) for patients who did not participate in exercise interventions, compared to 2.6% (n=89) for patients who exercised whilst in ICU

Investment in Cellulosic Biofuel Refineries: Do Waivable Biofuel Mandates Matter?

We develop a conceptual model to study the impact of mandate policies on stimulating investment in cellulosic biofuel refineries. In a two-period framework, we compare the first-period investment level (FIL) under three scenarios: laissez-faire, non-waivable mandate (NWM) policy, and waivable mandate (WM) policy. Results show that when plant-level marginal costs are increasing then both NWM policy and WM policy may stimulate FIL. The WM policy has a smaller impact than does the NWM policy. When the plant-level marginal costs are constants, however, WM policy does not increase FIL but does increase the expected profit of more efficient investors

Vertical whiteboarding: Riding the wave of student activity in a mathematics classroom

In 2014 we commenced working on the Inspiring Mathematics and Science in Teacher Education (IMSITE) project, aimed at improving mathematics and science education in Australia by improving the recruitment, development and retention of mathematics and science teachers. In this project we undertook a range of activities, the most exciting of which was the introduction of whiteboarding as a tool to actively engage high school students with mathematics

Scientific, Legal, and Ethical Concerns About AI-Based Personnel Selection Tools: A Call to Action

Organizations are increasingly turning toward personnel selection tools that rely on artificial intelligence (AI) technologies and machine learning algorithms that, together, intend to predict the future success of employees better than traditional tools. These new forms of assessment include online games, video-based interviews, and big data pulled from many sources, including test responses, test-taking behavior, applications, resumes, and social media. Speedy processing, lower costs, convenient access, and applicant engagement are often and rightfully cited as the practical advantages for using these selection tools. At the same time, however, these tools raise serious concerns about their effectiveness in terms of their conceptual relevance to the job, their basis in a job analysis to ensure job relevancy, their measurement characteristics (reliability and stability), their validity in predicting employee-relevant outcomes, their evidence and normative information being updated appropriately, and the associated ethical concerns around what information is being represented to employers and told to job candidates. This paper explores these concerns, concluding with an urgent call to industrial and organizational psychologists to extend existing professional standards for employment testing to these new AI and machine learning based forms of testing, including standards and requirements for their documentation