“Cre’n sorçh dy Ghaelg t’ou loayrt nish?”: The intersection of ideologies and morphosyntactic variation in new speakers of Manx Gaelic

This thesis explores language production and linguistic beliefs in a community of New Speakers. New Speakers are a speaker profile that have emerged from language revitalization efforts in various minoritized language communities (e.g. Irish - O’Rourke and Walsh, 2015; Galician - O’Rourke and Ramallo, 2015). New Speakers generally acquire their minority language primarily through means other than first language transmission in the home (O’Rourke, Pujolar, and Ramallo, 2015: 1), reaching “a socially and communicatively consequential level of competence” (Jaffe, 2015: 25) in their language. Research on New Speakers’ language practices indicates that both their language production and beliefs are highly variable (e.g. Hornsby, 2015; O’Rourke and Walsh, 2015) and that language beliefs may shape language practices in New Speaker communities (Rodriguez-Ordoñez, 2020; Enriquez-García, 2017). This thesis specifically explores the intersection between morphosyntactic variation and language beliefs among New Speakers of Manx, the minoritized Celtic language spoken by around 2200 people in the Isle of Man (Isle of Man Government, 2022). Manx underwent extreme minoritization in the 19th and early 20th centuries, and by the mid-20th century ceased to be spoken by a community of traditional native speakers (Broderick, 1991). Subsequent revitalization efforts from the late 20th century onwards have resulted in a community of New Speakers, variation in whose production and beliefs is also noted (e.g. McNulty, 2023a, Ó hIfearnáin: 2015a; 2015b). This thesis expands on this research, exploring language practices among speakers of Manx through the New Speaker framework, using the case study of Manx to examine how this framework might apply to atypical or lesser-studied minoritized varieties. It employs both qualitative and quantitative data collected through an extended period of ethnographic fieldwork conducted in the Isle of Man through the medium of Manx itself. The thesis investigates how New Speakers of Manx vary in their production of certain morphosyntactic constructions, as well as how they think and feel about these constructions, tying into broader themes of language ideologies and attitudes. It presents an original theoretical framework outlining the broad language beliefs present in the Manx New Speaker community. This framework explains how patterns of variation observed among these speakers might be analysed as individual speakers’ agentive use of particular constructions available to them in Manx to index commonly-held beliefs about language and linguistic identity to other community members. Therefore, this thesis has implications for how such indexicalities and patterns of variation develop in nascent varieties like Manx, which will be applicable to other minoritized and contact varieties more broadly

Making waves: Library IT as a disruptive force

This presentation addresses special challenges and opportunities that Library IT departments face as they take a larger role in initiating change within an organization

Positively Biased Appraisals in Everyday Life: When Do They Benefit Mental Health and When Do They Harm It?

To promote optimal mental health, is it best to evaluate negative experiences accurately or in a positively biased manner? In an attempt to reconcile inconsistent prior research addressing this question, we predicted that the tendency to form positively biased appraisals of negative experiences may reduce the motive to address those experiences and thereby lead to poorer mental health in the context of negative experiences that are controllable and severe but lead to better mental health in the context of controllable negative experiences that are less severe by promoting positive feelings without invoking serious consequences from unaddressed problems. In 2 longitudinal studies, individuals in new marriages were interviewed separately about their ongoing stressful experiences, and their own appraisals of those experiences were compared with those of the interviewers. Across studies, spouses\u27 tendencies to form positively biased appraisals of their stressful experiences predicted fewer depressive symptoms over the subsequent 4 years among individuals judged to be facing relatively mild experiences but more depressive symptoms among individuals judged to be facing relatively severe experiences. Furthermore, in Study 2, these effects were mediated by changes in those experiences, such that the interaction between the tendency to form positively biased appraisals of stressful experiences and the objectively rated severity of initial levels of those experiences directly predicted changes in those experiences, which in turn accounted for changes in depressive symptoms. These findings suggest that cognitive biases are not inherently positive or negative; their implications for mental health depend on the context in which they occur

Mother to offspring transmission of chronic wasting disease in Reeves' Muntjac deer

The horizontal transmission of prion diseases has been well characterized in bovine spongiform encephalopathy (BSE), chronic wasting disease (CWD) of deer and elk and scrapie of sheep, and has been regarded as the primary mode of transmission. Few studies have monitored the possibility of vertical transmission occurring within an infected mother during pregnancy. To study the potential for and pathway of vertical transmission of CWD in the native cervid species, we used a small cervid model-the polyestrous breeding, indoor maintainable, Reeves' muntjac deer-and determined that the susceptibility and pathogenesis of CWD in these deer reproduce that in native mule and white-tailed deer. Moreover, we demonstrate here that CWD prions are transmitted from doe to fawn. Maternal CWD infection also appears to result in lower percentage of live birth offspring. In addition, evolving evidence from protein misfolding cyclic amplification (PMCA) assays on fetal tissues suggest that covert prion infection occurs in utero. Overall, our findings demonstrate that transmission of prions from mother to offspring can occur, and may be underestimated for all prion diseases

Optimization of a Low Cost and Broadly Sensitive Genotyping Assay for HIV-1 Drug Resistance Surveillance and Monitoring in Resource-Limited Settings

Commercially available HIV-1 drug resistance (HIVDR) genotyping assays are expensive and have limitations in detecting non-B subtypes and circulating recombinant forms that are co-circulating in resource-limited settings (RLS). This study aimed to optimize a low cost and broadly sensitive in-house assay in detecting HIVDR mutations in the protease (PR) and reverse transcriptase (RT) regions of pol gene. The overall plasma genotyping sensitivity was 95.8% (N = 96). Compared to the original in-house assay and two commercially available genotyping systems, TRUGENE® and ViroSeq®, the optimized in-house assay showed a nucleotide sequence concordance of 99.3%, 99.6% and 99.1%, respectively. The optimized in-house assay was more sensitive in detecting mixture bases than the original in-house (N = 87, P<0.001) and TRUGENE® and ViroSeq® assays. When the optimized in-house assay was applied to genotype samples collected for HIVDR surveys (N = 230), all 72 (100%) plasma and 69 (95.8%) of the matched dried blood spots (DBS) in the Vietnam transmitted HIVDR survey were genotyped and nucleotide sequence concordance was 98.8%; Testing of treatment-experienced patient plasmas with viral load (VL) ≥ and <3 log10 copies/ml from the Nigeria and Malawi surveys yielded 100% (N = 46) and 78.6% (N = 14) genotyping rates, respectively. Furthermore, all 18 matched DBS stored at room temperature from the Nigeria survey were genotyped. Phylogenetic analysis of the 236 sequences revealed that 43.6% were CRF01_AE, 25.9% subtype C, 13.1% CRF02_AG, 5.1% subtype G, 4.2% subtype B, 2.5% subtype A, 2.1% each subtype F and unclassifiable, 0.4% each CRF06_CPX, CRF07_BC and CRF09_CPX

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

<strong>We Need Diverse Histories: Systemic Racism in Young Adult Historical Fantasy</strong>

Throughout my project, I focus on contemporary young adult historical fantasies that engage with legacies of systemic racism and Western Imperialism—a publishing trend that has developed due to an increased call for stories of racial inclusion in YA literature. These texts aim to create a more inclusive historical imagination by telling fictionalized histories that center people of color. Given the current political climate surrounding Critical Race Theory, my project analyzes how these texts both challenge and inadvertently perpetuate the logic of systemic racism. I argue that these historical fantasies attempt to acknowledge and untangle legacies of racism for audiences who, in the face of today’s reactionary political climate, may very well not be taught about them in their schools. My approach focuses on how, in their exploration of racism, these novels attempt corrective representation in the context of current social justice and racial reckoning movements, and grapple with the legacy of institutional racism in the here and now. As such, my project argues that we not only need diverse books in Western young adult fiction, but we also need more books that are willing to confront the persistent problems of systemic racism without perpetuating racial stereotypes or Eurocentric viewpoints. </p

Positively biased appraisals in everyday life: When do they benefit mental health and when do they harm it?

To promote optimal mental health, is it best to evaluate negative experiences accurately or in a positively biased manner? In an attempt to reconcile inconsistent prior research addressing this question, we predicted that the tendency to form positively biased appraisals of negative experiences may reduce the motive to address those experiences and thereby lead to poorer mental health in the context of negative experiences that are controllable and severe but lead to better mental health in the context of controllable negative experiences that are less severe by promoting positive feelings without invoking serious consequences from unaddressed problems. In 2 longitudinal studies, individuals in new marriages were interviewed separately about their ongoing stressful experiences, and their own appraisals of those experiences were compared with those of the interviewers. Across studies, spouses’ tendencies to form positively biased appraisals of their stressful experiences predicted fewer depressive symptoms over the subsequent 4 years among individuals judged to be facing relatively mild experiences but more depressive symptoms among individuals judged to be facing relatively severe experiences. Furthermore, in Study 2, these effects were mediated by changes in those experiences, such that the interaction between the tendency to form positively biased appraisals of stressful experiences and the objectively rated severity of initial levels of those experiences directly predicted changes in those experiences, which in turn accounted for changes in depressive symptoms. These findings suggest that cognitive biases are not inherently positive or negative; their implications for mental health depend on the context in which they occur