Vibrational frequencies and tuning of the African mbira

The acoustic spectrum of the mbira, a musical instrument from Africa that produces sound by the vibration of cantilevered metal rods, has been measured. It is found that the most prominent overtones present in the spectrum have frequencies that are approximately 5 and 14 times the lowest frequency. A finite-element model of the vibration of the key that takes into account the acoustic radiation efficiency of the various normal modes reveals that the far-field power spectrum is dominated by modes involving predominately transverse motion of the key. Modes involving longitudinal motion do not radiate efficiently, and therefore contribute little to the sound produced. The high frequencies of the dominant overtones relative to the fundamental make it unlikely that the tunings of the mbira that are used by expert musicians are determined by matching the fundamental frequencies of the upper keys with the overtones of the lower keys

Kaon Condensation in a Nambu--Jona-Lasinio (NJL) Model at High Density

We demonstrate a fully self-consistent microscopic realization of a kaon-condensed colour-flavour locked state (CFLK0) within the context of a mean-field NJL model at high density. The properties of this state are shown to be consistent with the QCD low-energy effective theory once the proper gauge neutrality conditions are satisfied, and a simple matching procedure is used to compute the pion decay constant, which agrees with the perturbative QCD result. The NJL model is used to compare the energies of the CFLK0 state to the parity even CFL state, and to determine locations of the metal/insulator transition to a phase with gapless fermionic excitations in the presence of a non-zero hypercharge chemical potential and a non-zero strange quark mass. The transition points are compared with results derived previously via effective theories and with partially self-consistent NJL calculations. We find that the qualitative physics does not change, but that the transitions are slightly lower.Comment: 21 pages, ReVTeX4. Clarified discussion and minor change

Characterization and optimization of bilosomes for oral vaccine delivery

Oral vaccines offer significant benefits due to the ease of administration, better patient compliance and non-invasive, needle-free administration. However, this route is marred by the harsh gastro intestinal environment which is detrimental to many vaccine formats. To address this, a range of delivery systems have been considered including bilosomes; these are bilayer vesicles constructed from non-ionic surfactants combined with the inclusion of bile salts which can stabilize the vesicles in the gastro intestinal tract by preventing membrane destabilization. The aim of this study was to investigate the effect of formulation parameters on bilosome carriers using Design of Experiments to select an appropriate formulation to assess in vivo. Bilosomes were constructed from monopalmitoylglycerol, cholesterol, dicetyl phosphate and sodium deoxycholate at different blends ratios. The optimized bilosome formulation was identified and the potential of this formulation as an oral vaccine delivery system were assessed in biodistribution and vaccine efficacy studies. Results showed that the larger bilosomes vesicles (~6 µm versus 2 µm in diameter) increased uptake within the Peyer's patches and were able to reduce median temperature differential change and promote a reduction in viral cell load in an influenza challenge study

Consideration of the efficacy of non-ionic vesicles in the targeted delivery of oral vaccines

The fundamentals of this research were to exploit non-ionic surfactant technology for delivery and administration of vaccine antigens across the oral route and to gain a better understanding of vaccine trafficking. Using a newly developed method for manufacture of non-ionic surfactant vesicles (niosomes and bilosomes) lower process temperatures were adopted thus reducing antigen exposure to potentially damaging conditions. Vesicles prepared by this method offered high protection to enzymatic degradation, with only ~10 % antigen loss measured when vesicles incorporating antigen were exposed to enzyme digestion. Interestingly, when formulated using this new production method, the addition of bile salt to the vesicles offered no advantage in terms of stability within simulated gastro-intestinal conditions. Considering their ability to deliver antigen to their target site, results demonstrated that incorporation of antigen within vesicles enhanced delivery and targeting of the antigen to the Peyer's Patch, again with niosomes and bilosomes offering similar efficiency. Delivery to both the Peyer's patches and mesentery lymphatics was shown to be dose dependent at lower concentrations, with saturation kinetics applying at higher concentrations. This demonstrates that in the formulation of vaccine delivery systems, the lipid/antigen dose ratio is not only a key factor in production cost, but is equally a key factor in the kinetics of delivery and targeting of a vaccine system

'It's complicated': reflections on teaching citizenship in Aotearoa New Zealand

The recently redesigned Massey University BA aims to produce responsible, world-conscious graduates who are active citizens, and who demonstrate a critical understanding of the peoples and cultures of 21st century Aotearoa New Zealand and the influences that have shaped them. The suite of compulsory core courses that emerged from this redesign process were developed before the university expressed a commitment to becoming Te Tiriti-led and were not explicitly designed with decolonisation in mind, but they ask questions and provoke reflection that we hope will contribute to decolonisation through the production of a cohort of graduates who have reflected on the multiple factors shaping their own identity, including New Zealand’s colonial past, can locate themselves in relation to global issues, and who have begun to think about questions of and possibilities for agency and action as citizens of ANZ and of the globe. These courses often unsettle indigenous and settler identities and relationships, and challenge student thinking about the rights and responsibilities they have at home and in the wider world. In this paper we reflect on the process of developing and teaching this course as a group of primarily settler / pākehā academics in conversation with Māori colleagues, and on our own learning through teaching. To do this we draw from our experiences and from research undertaken on the teaching of global citizenship in the core to interrogate our roles and responsibilities as academics in relation to decolonisation

Development of a solid dosage platform for the oral delivery of bilayer vesicles

Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10 % mannitol and 10 % dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules

Graphene plasmonics : ultra-tunable graphene light source

Free-electron-based light sources have long attracted interest due to their continuous tunability that has been demonstrated to extend across the electromagnetic spectrum from millimetre waves and microwaves through the infrared and visible to ultraviolet and X-ray regions. However this intrinsic tunability, particularly at short wavelengths, usually involves sources that are large and costly. The prospect of a compact, continuously tunable light source with the capability to generate short-wavelength ultraviolet and even X-ray light is an exciting one for many scientific, medical and engineering applications

Intermediate Tail Dependence: A Review and Some New Results

The concept of intermediate tail dependence is useful if one wants to quantify the degree of positive dependence in the tails when there is no strong evidence of presence of the usual tail dependence. We first review existing studies on intermediate tail dependence, and then we report new results to supplement the review. Intermediate tail dependence for elliptical, extreme value and Archimedean copulas are reviewed and further studied, respectively. For Archimedean copulas, we not only consider the frailty model but also the recently studied scale mixture model; for the latter, conditions leading to upper intermediate tail dependence are presented, and it provides a useful way to simulate copulas with desirable intermediate tail dependence structures.Comment: 25 pages, 1 figur

Whole body and splanchnic amino acid metabolism in sheep during an acute endotoxin challenge

Acknowledgements The expertise of A. Graham Calder and Susan Anderson for the various stable isotope analyses is gratefully recognised. Ngaire Dennison is also thanked for her surgical expertise with the trans-splanchnic tissue catheter preparations. This study was supported by funds provided to the Rowett Institute of Nutrition and Health, University of Aberdeen and Biomathematics and Statistics Scotland by the Rural and Environment Science and Analytical Services Division of the Scottish Government. S. O. H. was a recipient of a FoRST (NZ) award to study abroad.Peer reviewedPostprin