From Mutation to Disarticulation: Terror and the Body in Don DeLillo’s Falling Man

Don DeLillo’s Falling Man addresses cultural changes within the age of postmodern indifference and global terror, as the reaction to the image of a falling body becomes controversial following the events of 9/11. After being initially removed by the media, Richard Drew’s provocative photo titled “The Falling Man” captures a body falling against the backdrop of the World Trade Center, and is recovered and reexamined in DeLillo’s novel. Several types of bodily disturbances are illuminated in Falling Man as the fictional bodies of both American citizens and foreign terrorists become susceptible to strange mutations and disarticulations. DeLillo uses the bodily form as a reference point to expose and analyze the hidden atrocities of American exceptionalism—a system that accepts and allows actual human bodies to become the waste by-product of these global exchanges. Image and reality have become blurred in the era of postmodernity, and the outrage over Drew’s intriguing photo immediately after 9/11 should raise suspicion as to this image’s cultural significance. By encompassing a strange mix of bodily concerns such as viral infections, detached faces, and the unique phenomenon of organic shrapnel, DeLillo unearths the suffering body from its hiding place and brings to the forefront again in Falling Man

In an interconnected world: Joint research priorities for the environment, agriculture and infectious disease

In 2008 the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) commissioned ten think-tanks to work on disease-specific and thematic reference groups to identify top research priorities that would advance the research agenda on infectious diseases of poverty, thus contributing to improvements in human health. The first of the thematic reference group reports - on environment, agriculture and infectious diseases of poverty - was recently released. In this article we review, from an insider perspective, the strengths and weaknesses of this thematic reference group report and highlight key messages for policy-makers, funders and researchers

Computer-guided concentration-controlled trials in autoimmune disorders

A randomized concentration-controlled clinical trial (RCCCT) is an alternate experimental design to the standard dose-controlled study. In a RCCCT, patients are randomly assigned to predefined plasma or blood drug concentration ranges (low, medium, and high). With the caveat that concentration ranges are sufficiently separated, this design should enhance the ability to discover important concentration response relationships. FK-506, a potent and promising immunosuppressive agent for prevention and treatment of graft rejection, has shown significant clinical activity in some immune-mediated disorders. To implement the RCCCT design, a novel FK-506 intelligent dosing system (IDS) was used to guide all doses to prospectively achieve the target concentration range specified in the study protocol. Patients enrolled in these trials suffered from a variety of autoimmune disorders, including multiple sclerosis, primary biliary cirrhosis, psoriasis, autoimmune chronic active hepatitis, and nephrotic syndrome. We observed excellent predictive performance of the IDS for all patients. The accuracy (mean prediction error) of the IDS was −0.022 ng/ml and the precision (standard deviation of the prediction error) was 0.119 ng/ml. Thus, the IDS is both accurate and reproducible for autoimmune patients. We conclude that the RCCCT design, guided by an accurate and precise IDS, is an informative and cost-effective approach for evaluation of efficacy and safety of effective but highly toxic agents. © 1993 Raven Press, Ltd., New York