815 research outputs found
Religion, Multiculturalism, and Phenomenology as a Critical Practice: Lessons from the Algerian War of Independence
In the Algerian War of Independence, women famously used both traditional and modern clothing as part of their revolutionary efforts against French colonialism. This paper uncovers some of the principal lessons of this historical episode through a phenomenological exploration of agency, religion, and political transformation. Part I draws primarily on the philosophical insights of Martin Heidegger and Maurice Merleau-Ponty alongside the memoirs of Zohra Drif, a young woman member of the Algerian Front de LibĂ©ration Nationale, in order to explore the worldly and habitual nature of human agency in contrast to the Enlightenment stress on individual rationality and autonomy. Part II turns to John Russonâs phenomenological interpretation of religion in order to argue for the ineluctable significance of religion on human existence, in contrast to the modern tendency to oppose religious tradition and secular modernity. Part III analyzes the dynamics of intercultural communication, and argues for the political power of phenomenology as a critical enterprise that enables more just and emancipatory visions of collective human life and political transformation to come to the fore.
Peer review process: Double-anonymous peer revie
Building a Disciplinary, World-Wide Data Infrastructure
Sharing scientific data, with the objective of making it fully discoverable,
accessible, assessable, intelligible, usable, and interoperable, requires work
at the disciplinary level to define in particular how the data should be
formatted and described. Each discipline has its own organization and history
as a starting point, and this paper explores the way a range of disciplines,
namely materials science, crystallography, astronomy, earth sciences,
humanities and linguistics get organized at the international level to tackle
this question. In each case, the disciplinary culture with respect to data
sharing, science drivers, organization and lessons learnt are briefly
described, as well as the elements of the specific data infrastructure which
are or could be shared with others. Commonalities and differences are assessed.
Common key elements for success are identified: data sharing should be science
driven; defining the disciplinary part of the interdisciplinary standards is
mandatory but challenging; sharing of applications should accompany data
sharing. Incentives such as journal and funding agency requirements are also
similar. For all, it also appears that social aspects are more challenging than
technological ones. Governance is more diverse, and linked to the discipline
organization. CODATA, the RDA and the WDS can facilitate the establishment of
disciplinary interoperability frameworks. Being problem-driven is also a key
factor of success for building bridges to enable interdisciplinary research.Comment: Proceedings of the session "Building a disciplinary, world-wide data
infrastructure" of SciDataCon 2016, held in Denver, CO, USA, 12-14 September
2016, to be published in ICSU CODATA Data Science Journal in 201
Beyond the human body: Claire Denis's ecologies
This article explores the work of Claire Denis beyond the focus on the human body through which it is commonly read. Addressing Beau Travail (1999) and The Intruder (2004), I examine an ecological impulse that manifests itself through a nonanthropocentric detailing of the coexistence of body and landscape, and a nonhierarchical attentiveness to the distributed agencies of humans, animals and things. I draw here in particular on Gilles Deleuzeâs notion of the crystal-image and on Jean-Luc Nancyâs thinking of ecotechnics, as elaborated in his essay on The Intruder (a film inspired by Nancyâs autobiographical essay, LâIntrus). In Beau Travail, Deleuzian crystals of time draw attention to the nonhuman histories of the landscape. In The Intruder, this crystalline structure persists, reactivating traces of nonhuman pasts, while a focus on canine gestures and responses signals nonhuman perceptual worlds in the present. Deleuzeâs âDesert Islandsâ, another text that shapes The Intruder, offers a further way of reading the filmâs attentiveness to the nonhumanâan attentiveness that extends, as Nancy suggests, to a consideration of environmental crisis
Epidermal Function in the Nematode, Caenorhabditis elegans
Epithelial sheets create the forces which shape embryos during the development of all metazoans. The external epithelia, or hypodermis, of the nematode Caenorhabditis elegans plays an essential role in shape change during embryogenesis and also maintains body shape during postembryonic development. Embryonic shape change, known as elongation, is mediated by actin microfilaments in the hypodermis which align circumferentially and contract, causing the embryo to change from a ball of cells, to a long, thin worm shape. A prerequisite to elongation is the migration of the hypodermis around the embryo from the dorsal surface to completely cover the embryo in a layer of hypodermal cells, a process known as enclosure. At the end of embryogenesis, the hypodermis secretes a multi-layered, collagenous exoskeleton, known as the cuticle, which maintains the elongated worm shape postembryonically. In this thesis, I have characterised three elongation-defective mutants which arrest during embryogenesis, and have also looked at the pattern of a cuticular collagen, DPY-7, throughout development using a novel monoclonal antibody, DPY7-5a. One of the embryonic lethal mutations, w4, lies on Chromosome I, between positions 6.2 and 9.9 on the genetic map. The majority of w4 homozygotes are defective in enclosure. The other two embryonic lethal mutations, ijDf1 and ijDf2 are the result of large deficiencies which have been physically mapped. ijDf2 extends from around position -0.9 to 0.7 on chromosome V and is approximately 2.2Mb in size. ijDf1 homozygotes appear to have a pre-enclosure defect in cell adhesion. ijDf1 extends from around position 18 to 23.5 on the X chromosome and is approximately 1.6Mb in size. ijDf1 homozygotes arrest as 1.5-fold stage embryos and this early elongation defect was rescued by injection of the genomic overlap of cosmids K09A9 and K09E9, plus the whole of cosmid C02C6. However, inhibition of the function of predicted genes contained in these cosmids did not produce the mutant phenotype seen in the deficiency. The characterisation of the DPY7-5a antibody suggests localisation of DPY-7 in the cortical layer of the cuticle. The study of the antibody pattern in a dpy-7 mutant demonstrates a clear reduction in secreted DPY-7. These results suggest that there are many molecular components in the complex process of embryonic elongation and the DPY7-5a antibody provides a novel mechanism to study postembryonic shape change and mechanisms of cuticle organisation within the hypodermis
Impact of smoking behavior on clozapine blood levels â a systematic review and metaâanalysis
Objective Tobacco smoking significantly impacts clozapine blood levels and has substantial implications on individual efficacy and safety outcomes. By investigating differences in clozapine blood levels in smoking and nonâsmoking patients on clozapine, we aim to provide guidance for clinicians how to adjust clozapine levels for patients on clozapine who change their smoking habits. Methods We conducted a metaâanalysis on clozapine blood levels, norclozapine levels, norclozapine/clozapine ratios and concentration to dose (C/D) ratios in smokers and nonâsmokers on clozapine. Data were metaâanalysed using a randomâeffects model with sensitivity analyses on dose, ethnic origin and study quality. Results Data from 23 studies were included in this metaâanalysis with 21 investigating differences between clozapine blood levels of smokers and nonâsmokers. In total, data from 7125 samples were included for the primary outcome (clozapine blood levels in ng/ml) in this metaâanalysis. A metaâanalysis of all betweenâsubject studies (N=16) found that clozapine blood levels were significantly lower in smokers compared to nonâsmokers (Standard Mean Difference (SMD) â0.39, 95% confidence interval (CI) â0.55 to â0.22,
Functional limitations in TBI and their relationship to job maintenance following work re-entry,â
Abstract. Using data from the Job Accommodation Network Information System (JANIS), the utility of self-reported functional limitations was examined in relationship to job maintenance for individuals with traumatic brain injury (TBI) who had returned to work. It was found that memory loss and attention/concentration concerns were the most common functional limitations reported. To further establish which limitations were associated with job maintenance, a binary logistic regression was applied. Results suggested that the presence of medical symptoms and emotional dysregulation were reliably and inversely associated with job maintenance. Implications are provided for further research as well as the practice of rehabilitation counseling
- âŠ