Total contact cast wall load in patients with a plantar forefoot ulcer and diabetes

BACKGROUND: The total contact cast (TCC) is an effective intervention to reduce plantar pressure in patients with diabetes and a plantar forefoot ulcer. The walls of the TCC have been indirectly shown to bear approximately 30 % of the plantar load. A new direct method to measure inside the TCC walls with capacitance sensors has shown that the anterodistal and posterolateral-distal regions of the lower leg bear the highest load. The objective of this study was to directly measure these two regions in patients with Diabetes and a plantar forefoot ulcer to further understand the mechanism of pressure reduction in the TCC. METHODS: A TCC was applied to 17 patients with Diabetes and a plantar forefoot ulcer. TCC wall load (contact area, peak pressure and max force) at the anterodistal and posterolateral-distal regions of the lower leg were evaluated with two capacitance sensor strips measuring 90 cm(2) (pliance®, novel GmbH, Germany). Plantar load (contact area, peak pressure and max force) was measured with a capacitance sensor insole (pedar®, novel GmbH, Germany) placed inside the TCC. Both pedar® and pliance® collected data simultaneously at a sampling rate of 50Hz synchronised to heel strike. The magnitude of TCC wall load as a proportion of plantar load was calculated. The TCC walls were then removed to determine the differences in plantar loading between the TCC and the cut down shoe-cast for the whole foot, rearfoot, midfoot and forefoot (region of interest). RESULTS: TCC wall load was substantial. The anterodistal lower leg recorded 48 % and the posterolateral-distal lower leg recorded 34 % of plantar contact area. The anterodistal lower leg recorded 28 % and the posterolateral-distal lower leg recorded 12 % of plantar peak pressure. The anterodistal lower leg recorded 12 % and the posterolateral-distal lower leg recorded 4 % of plantar max force. There were significant differences in plantar load between the TCC and the cut down shoe-cast for the whole foot, rearfoot, midfoot and forefoot (region of ulcer). Contact area significantly increased by 5 % beneath the whole foot, 8 % at the midfoot and 6 % at the forefoot in the shoe-cast (p < 0.05). Peak pressure significantly increased by 8 % beneath the midfoot and 13 % at the forefoot in the shoe-cast (p < 0.05). Max force significantly increased 6 % beneath the midfoot in the (shoe-cast p < 0.05). CONCLUSION: In patients with diabetes and a plantar forefoot ulcer, the walls of the TCC bear considerable load. Reduced plantar contact area in the TCC compared to the shoe-cast suggests that the foot is suspended by the considerable load bearing capacity of the walls of the TCC which contributes mechanically to the pressure reduction and redistribution properties of the TCC

Natural resources of Lake Earl and Smith River Delta

The Lake Earl/Smith River Delta area is a key coastal wetland situated in northern California. The Lake and Delta have retained much of their value to wildlife and serve as an important link in a chain of such wetlands that extend southward along the Pacific Ocean from Alaska to South America. Millions of water-associated birds of the Pacific Flyway utilize these areas as feeding and resting stops along their migration paths. In California, these wetlands also serve as a significant portion of the available wintering grounds for a major share of the birds within the flyway. The Smith River is also one of the State's most productive salmon and steelhead streams. Anadromous fish produced here provide thousands of angler use days to sport fishermen and contribute substantially to the commercial fishing catch off the northern coast. Because of the importance of coastal wetlands to the fish and wildlife of California, the Department of Fish and Game has initiated a high priority statewide inventory and assessment of these wetlands. This publication is an integral part of that program. This report identifies specific resources and uses; directs attention to problems; and recommends courses of action needed to insure resource protection. It is intended as a guide for citizens, planners, administrators and other interested in the use and development of California's coastal land and waters. (132pp.

Cratonic Basins as Effective Sediment Barriers in Continent‑Scale Sediment Routing Systems of Paleozoic North America

Provenance studies demonstrate the important control of plate boundary mountain building on continental sediment routing systems. Less well understood is if subsidence and uplift in cratons also has the potential to affect the organization of sediment routing systems on continental scales. New detrital zircon provenance data from the Michigan Basin in the Midcontinent of North America preserve evidence of intrabasin provenance heterogeneity in Cambrian, Ordovician, and middle Devonian strata. These results suggest that cratonic basins serve as effective sediment barriers that prevent mixing within and across basins from 10 to 100 s of millions of years. Internal sediment mixing, sorting, and dispersal may be achieved by a combination of sedimentary processes and inherited low relief topography. These observations are consistent with provenance data sets from eastern Laurentian Midcontinent basins that show locally and regionally variable provenance signatures during the early Paleozoic. By the late Devonian, provenance signatures throughout the basins homogenized, consistent with the emergence of transcontinental sediment transport systems associated with Appalachian orogenesis at the plate margin. These results demonstrate the importance of cratonic basins on local and regional sediment routing systems suggesting that these features may impede the integration of continental-scale sediment routings systems, particularly during periods of plate margin quiescence

Contributors to the Fall Issue/Notes

Notes by Wilmer L. McLaughlin, John F. Mendoza, Patrick F. Coughlin, William J. O\u27Connor, Arthur L. Beaudette, Henry M. Shine, Jr., William M. Dickson, and William B. Wombacher

Trends in the Globular Cluster Luminosity Function of Early-Type Galaxies

We present results from a study of the globular cluster luminosity function (GCLF) in a sample of 89 early-type galaxies observed as part of the ACS Virgo Cluster Survey. Using a Gaussian parametrization of the GCLF, we find a highly significant correlation between the GCLF dispersion, sigma, and the galaxy luminosity, M_B, in the sense that the GC systems in fainter galaxies have narrower luminosity functions. The GCLF dispersions in the Milky Way and M31 are fully consistent with this trend, implying that the correlation between sigma and galaxy luminosity is more fundamental than older suggestions that GCLF shape is a function of galaxy Hubble type. We show that the sigma - M_B relation results from a bonafide narrowing of the distribution of (logarithmic) cluster masses in fainter galaxies. We further show that this behavior is mirrored by a steepening of the GC mass function for relatively high masses, M >~ 3 x 10^5 M_sun, a mass regime in which the shape of the GCLF is not strongly affected by dynamical evolution over a Hubble time. We argue that this trend arises from variations in initial conditions and requires explanation by theories of cluster formation. Finally, we confirm that in bright galaxies, the GCLF "turns over" at the canonical mass scale of M_TO ~ 2 x 10^5 M_sun. However, we find that M_TO scatters to lower values (~1-2 x 10^5 M_sun) in galaxies fainter than M_B >~ -18.5, an important consideration if the GCLF is to be used as a distance indicator for dwarf ellipticals.Comment: 4 pages, 3 figures. Accepted for publication in ApJ Letters. Also available at http://www.cadc.hia.nrc.gc.ca/community/ACSVCS/publications.htm

Brain Parcellation Selection: An Overlooked Decision Point with Meaningful Effects on Individual Differences in Resting-State Functional Connectivity

Over the past decade extensive research has examined the segregation of the human brain into large-scale functional networks. The resulting network maps, i.e. parcellations, are now commonly used for the a priori identification of functional networks. However, the use of these parcellations, particularly in developmental and clinical samples, hinges on four fundamental assumptions: (1) the various parcellations are equally able to recover the networks of interest; (2) adult-derived parcellations well represent the networks in children\u27s brains; (3) network properties, such as within-network connectivity, are reliably measured across parcellations; and (4) parcellation selection does not impact the results with regard to individual differences in given network properties. In the present study we examined these assumptions using eight common parcellation schemes in two independent developmental samples. We found that the parcellations are equally able to capture networks of interest in both children and adults. However, networks bearing the same name across parcellations (e.g., default network) do not produce reliable within-network measures of functional connectivity. Critically, parcellation selection significantly impacted the magnitude of associations of functional connectivity with age, poverty, and cognitive ability, producing meaningful differences in interpretation of individual differences in functional connectivity based on parcellation choice. Our findings suggest that work employing parcellations may benefit from the use of multiple schemes to confirm the robustness and generalizability of results. Furthermore, researchers looking to gain insight into functional networks may benefit from employing more nuanced network identification approaches such as using densely-sampled data to produce individual-derived network parcellations. A transition towards precision neuroscience will provide new avenues in the characterization of functional brain organization across development and within clinical populations

Discovery of a Probable CH Star in the Globular Cluster M14 and Implications for the Evolution of Binaries in Clusters

We report the discovery of a probable CH star in the core of the Galactic globular cluster M14, identified from an integrated-light spectrum of the cluster obtained with the MOS spectrograph on the CFHT. From a high- resolution echelle spectrum of the same star obtained with the Hydra fiber positioner and bench spectrograph on the WIYN telescope, we measure a radial velocity of $-53.0\pm1.2$ km s$^{-1}$. Although this velocity is inconsistent with published estimates of the systemic radial velocity of M14 (eg, ${\bar {v_r}} \approx -123$ km s$^{-1}$), we use high-precision Hydra velocities for 20 stars in the central 2.6 arcminutes of M14 to calculate improved values for the cluster mean velocity and one-dimensional velocity dispersion: $-59.5\pm1.9$ km s$^{-1}$ and $8.2\pm1.4$ km s$^{-1}$, respectively. Both the star's location near the tip of the red giant branch in the cluster color magnitude diagram and its radial velocity therefore argue for membership in M14. Since the intermediate-resolution MOS spectrum shows not only enhanced CH absorption but also strong Swan bands of C$_2$, M14 joins Omega Cen as the only globular clusters known to contain classical CH stars. Although evidence for its duplicity must await additional radial velocity measurements, the CH star in M14 is probably, like all field CH stars, a spectroscopic binary with a degenerate (white dwarf) secondary. The candidate and confirmed CH stars in M14 and Omega Cen, and in a number of Galactic dSph galaxies, may then owe their existence to the long timescales for the shrinking and coalescence of hard binaries in low-concentration environments.Comment: Accepted to the Astrophysical Journal Letters. 13 pages, AAS LaTeX and three postscript figures (numbers 2,3,4). Entire paper (including Figure 1) available at http://www.hia.nrc.ca/DAO/SCIENCE/science.htm

The ACS Fornax Cluster Survey VII. Half-Light Radii of Globular Clusters in Early-Type Galaxies

We measure the half-light radii of globular clusters (GCs) in 43 galaxies from the ACS Fornax Cluster Survey (ACSFCS). We use these data to extend previous work in which the environmental dependencies of the half-light radii of GCs in early type galaxies in the ACS Virgo Cluster Survey (ACSVCS) were studied, and a corrected mean half-light radius (corrected for the observed environmental trends) was suggested as a reliable distance indicator. This work both increases the sample size for the study of the environmental dependencies, and adds leverage to the study of the corrected half-light radius as a possible distance indicator (since Fornax lies at a larger distance than the Virgo cluster). We study the environmental dependencies of the size of GCs using both a Principal Component Analysis as well as 2D scaling relations. We largely confirm the environmental dependencies shown in Jordan et al. (2005), but find evidence that there is a residual correlation in the mean half-light radius of GC systems with galaxy magnitude, and subtle differences in the other correlations - so there may not be a universal correction for the half-light radii of lower luminosity galaxy GC systems. The main factor determining the size of a GC in an early type galaxy is the GC color. Red GCs have = 2.8+/-0.3 pc, while blue GCs have = 3.4+/-0.3 pc. We show that for bright early-type galaxies (M_B < -19 mag), the uncorrected mean half-light radius of the GC system is by itself an excellent distance indicator (with error ~11%), having the potential to reach cosmologically interesting distances in the era of high angular resolution adaptive optics on large optical telescopes.Comment: ApJ in press, 19 pages, 16 figures