False discovery rate control for grouped or discretely supported p-values with application to a neuroimaging study

False discovery rate (FDR) control is important in multiple testing scenarios that are common in neuroimaging experiments, and p-values from such experiments may often arise from some discretely supported distribution or may be grouped in some way. Two situations that may lead to discretely supported distributions are when the p-values arise from Monte Carlo or permutation tests are used. Grouped p-values may occur when p-values are quantized for storage. In the neuroimaging context, grouped p-values may occur when data are stored in an integer-encoded form. We present a method for FDR control that is applicable in cases where only p-values are available for inference, and when those p-values are discretely supported or grouped. We assess our method via a comprehensive set of simulation scenarios and find that our method can outperform commonly used FDR control schemes in various cases. An implementation to a mouse imaging data set is used as an example to demonstrate the applicability of our approach.Peer Reviewe

A century-long record of plant evolution reconstructed from a coastal marsh seed bank

Evidence is mounting that climate-driven shifts in environmental conditions can elicit organismal evolution, yet there are sparingly few long-term records that document the tempo and progression of responses, particularly for plants capable of transforming ecosystems. In this study, we “resurrected” cohorts of a foundational coastal marsh sedge (Schoenoplectus americanus) from a time-stratified seed bank to reconstruct a century-long record of heritable variation in response to salinity exposure. Common-garden experiments revealed that S. americanus exhibits heritable variation in phenotypic traits and biomass-based measures of salinity tolerance. We found that responses to salinity exposure differed among the revived cohorts, with plants from the early 20th century exhibiting greater salinity tolerance than those from the mid to late 20th century. Fluctuations in salinity tolerance could reflect stochastic variation but a congruent record of genotypic variation points to the alternative possibility that the loss and gain in functionality are driven by selection, with comparisons to historical rainfall and paleosalinity records suggesting that selective pressures vary according to shifting estuarine conditions. Because salinity tolerance in S. americanus is tightly coupled to primary productivity and other vital ecosystem attributes, these findings indicate that organismal evolution merits further consideration as a factor shaping coastal marsh responses to climate change

Long-range three-body atom-diatom potential for doublet Li3{}_3

An accurate long-range {\em ab initio} potential energy surface has been calculated for the ground state ${}^2A'$ lithium trimer in the frozen diatom approximation using all electron RCCSD(T). The {\em ab initio} energies are corrected for basis set superposition error and extrapolated to the complete basis limit. Molecular van der Waals dispersion coefficients and three-body dispersion damping terms for the atom-diatomic dissociation limit are presented from a linear least squares fit and shown to be an essentially exact representation of the {\em ab initio} surface at large range

Towards understanding predictability in ecology: a forest gap model case study

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The Grizzly, February 13, 1996

Summer Research at Ursinus • Fairley Will Not Plead Insanity • Merck Announces HIV Drug Results • Faculty Spotlight: Dr. Lynn Thelen • Joe Clark, Gospel Choir Highlight Diversity Week • Information Superhighway Control • Captain Offender • In Search of Aristotle\u27s Prime Mover • An Entirely Warped Romantic Interlude • Hey Students, Take Some Initiative! • Do You Believe in Magic? • Take it Back, Captain Jack! • Not Slick Enough • Strike up the (String) Band! • Ursinus Handles Swarthmore, 70-39 • Ursinus Edges Washington, 64-62 • Swarthmore Sweeps UC Swim Teams • Gymnasts Victorious • Bears Regain Centennial Titlehttps://digitalcommons.ursinus.edu/grizzlynews/1374/thumbnail.jp

The Grizzly, February 27, 1996

Koestner Gives First-Hand Account of Date Rape • J-Board Charges Reimert Residents • Swastikas are Removed from Bomberger Hall • Buchanan Wins New Hampshire • The Skipped Diploma • Evolutionary Doubts • Fighting for Real Social Change • In Support of Healthier Relationships • Alan Morrison to Perform Recital • U.S.G.A. News • Faculty Spotlight: Dr. Peter Perreten • Staff Spotlight: Todd McKinney • Gymnasts End Season With a Win • Lacrosse Team Ranked 15th • Bears Compete at Indoor Championships • Lady Bears Fall in Conference Semishttps://digitalcommons.ursinus.edu/grizzlynews/1376/thumbnail.jp